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{{ | '''ARF GTPase-activating protein GIT1''' is an [[enzyme]] that in humans is encoded by the ''GIT1'' [[gene]].<ref name="pmid9826657">{{cite journal | vauthors = Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ | title = beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 24 | pages = 14082–14087 | date = December 1998 | pmid = 9826657 | pmc = 24330 | doi = 10.1073/pnas.95.24.14082 }}</ref><ref name="pmid10896954">{{cite journal | vauthors = Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ | title = The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing | journal = J Biol Chem | volume = 275 | issue = 29 | pages = 22373–22380 | date = August 2000 | pmid = 10896954 | pmc = | doi = 10.1074/jbc.275.29.22373 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GIT1 G protein-coupled receptor kinase interactor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28964| accessdate = }}</ref> | ||
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GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation---this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathway.<ref>{{cite journal | vauthors = Zhang H, Webb DJ, Asmussen H, Horwitz AF | title = Synapse formation is regulated by the signaling adaptor GIT1 | journal = J. Cell Biol. | volume = 161 | issue = 1 | pages = 131–142 | year = 2003 | pmid = 12695502 | pmc = 2172873 | doi = 10.1083/jcb.200211002 }}</ref> | |||
{{ | |||
< | ==Interactions== | ||
{{ | GIT1 has been shown to [[Protein-protein interaction|interact]] with: | ||
| | {{div col|colwidth=20em}} | ||
| | * [[ARHGEF7]],<ref name = pmid12473661/><ref name = pmid10428811>{{cite journal | vauthors = Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA | title = A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins | journal = J. Biol. Chem. | volume = 274 | issue = 32 | pages = 22393–400 | date = August 1999 | pmid = 10428811 | doi = 10.1074/jbc.274.32.22393}}</ref> | ||
}} | * [[Beta adrenergic receptor kinase]],<ref name = pmid9826657 /><ref name = pmid10896954 /> | ||
* [[GIT2]],<ref name = pmid12473661/> | |||
* [[PCLO]],<ref name = pmid12473661>{{cite journal | vauthors = Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E | title = The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6291–300 | date = February 2003 | pmid = 12473661 | doi = 10.1074/jbc.M212287200 }}</ref> | |||
* [[PLCG1]],<ref name = pmid14523024>{{cite journal | vauthors = Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC | title = GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49936–44 | date = December 2003 | pmid = 14523024 | doi = 10.1074/jbc.M307317200 }}</ref> | |||
* [[PPFIA4]]<ref name = pmid12629171/><ref name = pmid12923177/> | |||
* [[PTK2]],<ref name = pmid12473661/><ref name = pmid12629171/><ref name = pmid10938112>{{cite journal | vauthors = Zhao ZS, Manser E, Loo TH, Lim L | title = Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6354–63 | date = September 2000 | pmid = 10938112 | pmc = 86110 | doi = 10.1128/mcb.20.17.6354-6363.2000}}</ref> and | |||
* [[liprin-alpha-1]].<ref name = pmid12629171>{{cite journal | vauthors = Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E | title = Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting | journal = J. Neurosci. | volume = 23 | issue = 5 | pages = 1667–77 | date = March 2003 | pmid = 12629171 | doi = }}</ref><ref name = pmid12923177>{{cite journal | vauthors = Ko J, Na M, Kim S, Lee JR, Kim E | title = Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins | journal = J. Biol. Chem. | volume = 278 | issue = 43 | pages = 42377–85 | date = October 2003 | pmid = 12923177 | doi = 10.1074/jbc.M307561200 }}</ref> | |||
{{Div col end}} | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Hoefen RJ, Berk BC | title = The multifunctional GIT family of proteins | journal = J. Cell Sci. | volume = 119 | issue = Pt 8 | pages = 1469–1475 | year = 2006 | pmid = 16598076 | doi = 10.1242/jcs.02925 }} | |||
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }} | |||
*{{cite journal | * {{cite journal | vauthors = Zhao ZS, Manser E, Loo TH, Lim L | title = Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6354–6363 | year = 2000 | pmid = 10938112 | pmc = 86110 | doi = 10.1128/MCB.20.17.6354-6363.2000 }} | ||
*{{cite journal | * {{cite journal | vauthors = Kawachi H, Fujikawa A, Maeda N, Noda M | title = Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 12 | pages = 6593–6598 | year = 2001 | pmid = 11381105 | pmc = 34398 | doi = 10.1073/pnas.041608698 }} | ||
* {{cite journal | vauthors = Manabe R, Kovalenko M, Webb DJ, Horwitz AR | title = GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration | journal = J. Cell Sci. | volume = 115 | issue = Pt 7 | pages = 1497–510 | year = 2002 | pmid = 11896197 | doi = }} | |||
*{{cite journal | * {{cite journal | vauthors = Nishiya N, Shirai T, Suzuki W, Nose K | title = Hic-5 interacts with GIT1 with a different binding mode from paxillin | journal = J. Biochem. | volume = 132 | issue = 2 | pages = 279–89 | year = 2003 | pmid = 12153727 | doi = 10.1093/oxfordjournals.jbchem.a003222 }} | ||
* {{cite journal | vauthors = Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E | title = The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6291–6300 | year = 2003 | pmid = 12473661 | doi = 10.1074/jbc.M212287200 }} | |||
*{{cite journal | * {{cite journal | vauthors = Shin H, Wyszynski M, Huh KH, Valtschanoff JG, Lee JR, Ko J, Streuli M, Weinberg RJ, Sheng M, Kim E | title = Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha | journal = J. Biol. Chem. | volume = 278 | issue = 13 | pages = 11393–11401 | year = 2003 | pmid = 12522103 | doi = 10.1074/jbc.M211874200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E | title = Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting | journal = J. Neurosci. | volume = 23 | issue = 5 | pages = 1667–77 | year = 2003 | pmid = 12629171 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Ko J, Na M, Kim S, Lee JR, Kim E | title = Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins | journal = J. Biol. Chem. | volume = 278 | issue = 43 | pages = 42377–42385 | year = 2004 | pmid = 12923177 | doi = 10.1074/jbc.M307561200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC | title = GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49936–49944 | year = 2004 | pmid = 14523024 | doi = 10.1074/jbc.M307317200 }} | ||
*{{cite journal | * {{cite journal | vauthors = van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, Berk BC | title = GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions | journal = Circ. Res. | volume = 94 | issue = 8 | pages = 1041–1049 | year = 2004 | pmid = 15016733 | doi = 10.1161/01.RES.0000125627.77235.0C}} | ||
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–12135 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }} | |||
*{{cite journal | * {{cite journal | vauthors = Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE | title = A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 853–865 | year = 2004 | pmid = 15383276 | doi = 10.1016/j.molcel.2004.09.016 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
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*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{ | ==External links== | ||
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00001556 GIT1] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] | |||
{{gene-17-stub}} |
Latest revision as of 20:00, 8 November 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.[1][2][3]
GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation---this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathway.[4]
Interactions
GIT1 has been shown to interact with:
References
- ↑ 1.0 1.1 Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (December 1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc Natl Acad Sci U S A. 95 (24): 14082–14087. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657.
- ↑ 2.0 2.1 Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (August 2000). "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing". J Biol Chem. 275 (29): 22373–22380. doi:10.1074/jbc.275.29.22373. PMID 10896954.
- ↑ "Entrez Gene: GIT1 G protein-coupled receptor kinase interactor 1".
- ↑ Zhang H, Webb DJ, Asmussen H, Horwitz AF (2003). "Synapse formation is regulated by the signaling adaptor GIT1". J. Cell Biol. 161 (1): 131–142. doi:10.1083/jcb.200211002. PMC 2172873. PMID 12695502.
- ↑ 5.0 5.1 5.2 5.3 Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (February 2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo". J. Biol. Chem. 278 (8): 6291–300. doi:10.1074/jbc.M212287200. PMID 12473661.
- ↑ Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA (August 1999). "A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins". J. Biol. Chem. 274 (32): 22393–400. doi:10.1074/jbc.274.32.22393. PMID 10428811.
- ↑ Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC (December 2003). "GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor". J. Biol. Chem. 278 (50): 49936–44. doi:10.1074/jbc.M307317200. PMID 14523024.
- ↑ 8.0 8.1 8.2 Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (March 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. PMID 12629171.
- ↑ 9.0 9.1 Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
- ↑ Zhao ZS, Manser E, Loo TH, Lim L (September 2000). "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly". Mol. Cell. Biol. 20 (17): 6354–63. doi:10.1128/mcb.20.17.6354-6363.2000. PMC 86110. PMID 10938112.
Further reading
- Hoefen RJ, Berk BC (2006). "The multifunctional GIT family of proteins". J. Cell Sci. 119 (Pt 8): 1469–1475. doi:10.1242/jcs.02925. PMID 16598076.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Zhao ZS, Manser E, Loo TH, Lim L (2000). "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly". Mol. Cell. Biol. 20 (17): 6354–6363. doi:10.1128/MCB.20.17.6354-6363.2000. PMC 86110. PMID 10938112.
- Kawachi H, Fujikawa A, Maeda N, Noda M (2001). "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6593–6598. doi:10.1073/pnas.041608698. PMC 34398. PMID 11381105.
- Manabe R, Kovalenko M, Webb DJ, Horwitz AR (2002). "GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration". J. Cell Sci. 115 (Pt 7): 1497–510. PMID 11896197.
- Nishiya N, Shirai T, Suzuki W, Nose K (2003). "Hic-5 interacts with GIT1 with a different binding mode from paxillin". J. Biochem. 132 (2): 279–89. doi:10.1093/oxfordjournals.jbchem.a003222. PMID 12153727.
- Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo". J. Biol. Chem. 278 (8): 6291–6300. doi:10.1074/jbc.M212287200. PMID 12473661.
- Shin H, Wyszynski M, Huh KH, Valtschanoff JG, Lee JR, Ko J, Streuli M, Weinberg RJ, Sheng M, Kim E (2003). "Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha". J. Biol. Chem. 278 (13): 11393–11401. doi:10.1074/jbc.M211874200. PMID 12522103.
- Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. PMID 12629171.
- Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–42385. doi:10.1074/jbc.M307561200. PMID 12923177.
- Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC (2004). "GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor". J. Biol. Chem. 278 (50): 49936–49944. doi:10.1074/jbc.M307317200. PMID 14523024.
- van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, Berk BC (2004). "GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions". Circ. Res. 94 (8): 1041–1049. doi:10.1161/01.RES.0000125627.77235.0C. PMID 15016733.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
External links
- GIT1 Info with links in the Cell Migration Gateway
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