GCM2: Difference between revisions

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{{Infobox_gene}}
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'''Chorion-specific transcription factor GCMb''' is a [[protein]] that in humans is encoded by the ''GCM2'' [[gene]].<ref name="pmid9928992">{{cite journal |vauthors=Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T | title = Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene | journal = FEBS Lett | volume = 442 | issue = 2–3 | pages = 151–6 |date=Feb 1999 | pmid = 9928992 | pmc =  | doi =10.1016/S0014-5793(98)01650-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9247| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glial cells missing homolog 2 (Drosophila)
| HGNCid = 4198
| Symbol = GCM2
| AltSymbols =; GCMB; hGCMb
| OMIM = 603716
| ECnumber =
| Homologene = 3490
| MGIid = 1861438
  | GeneAtlas_image1 = PBB_GE_GCM2_220799_at_tn.png
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030643 |text = cellular phosphate ion homeostasis}} {{GNF_GO|id=GO:0060017 |text = parathyroid gland development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9247
    | Hs_Ensembl = ENSG00000124827
    | Hs_RefseqProtein = NP_004743
    | Hs_RefseqmRNA = NM_004752
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 10981442
    | Hs_GenLoc_end = 10990160
    | Hs_Uniprot = O75603
    | Mm_EntrezGene = 107889
    | Mm_Ensembl = ENSMUSG00000021362
    | Mm_RefseqmRNA = NM_008104
    | Mm_RefseqProtein = NP_032130
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 41112399
    | Mm_GenLoc_end = 41121157
    | Mm_Uniprot = Q2TB03
  }}
}}
'''Glial cells missing homolog 2 (Drosophila)''', also known as '''GCM2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9247| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9247| accessdate = }}</ref>
| summary_text = The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist|30em}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kanemura Y, Hiraga S, Arita N, ''et al.'' |title=Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene. |journal=FEBS Lett. |volume=442 |issue= 2-3 |pages= 151-6 |year= 1999 |pmid= 9928992 |doi=  }}
*{{cite journal  |vauthors=Kammerer M, Pirola B, Giglio S, Giangrande A |title=GCMB, a second human homolog of the fly glide/gcm gene |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1–2 |pages= 43–7 |year= 1999 |pmid= 10343099 |doi=10.1159/000015210 }}
*{{cite journal  | author=Kammerer M, Pirola B, Giglio S, Giangrande A |title=GCMB, a second human homolog of the fly glide/gcm gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 43-7 |year= 1999 |pmid= 10343099 |doi=  }}
*{{cite journal  |vauthors=Correa P, Akerström G, Westin G |title=Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism |journal=Clin. Endocrinol. |volume=57 |issue= 4 |pages= 501–5 |year= 2002 |pmid= 12354132 |doi=10.1046/j.1365-2265.2002.01627.x }}
*{{cite journal  | author=Correa P, Akerström G, Westin G |title=Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism. |journal=Clin. Endocrinol. (Oxf) |volume=57 |issue= 4 |pages= 501-5 |year= 2002 |pmid= 12354132 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Maret A, Bourdeau I, Ding C |title=Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 1 |pages= 8–12 |year= 2004 |pmid= 14715818 |doi=10.1210/jc.2003-030733 |display-authors=etal}}
*{{cite journal  | author=Maret A, Bourdeau I, Ding C, ''et al.'' |title=Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 1 |pages= 8-12 |year= 2004 |pmid= 14715818 |doi=  }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Kebebew E, Peng M, Wong MG |title=GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism |journal=Surgery |volume=136 |issue= 6 |pages= 1261–6 |year= 2005 |pmid= 15657585 |doi= 10.1016/j.surg.2004.06.056 |display-authors=etal}}
*{{cite journal  | author=Kebebew E, Peng M, Wong MG, ''et al.'' |title=GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism. |journal=Surgery |volume=136 |issue= 6 |pages= 1261-6 |year= 2005 |pmid= 15657585 |doi= 10.1016/j.surg.2004.06.056 }}
*{{cite journal  |vauthors=Thomée C, Schubert SW, Parma J |title=GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 5 |pages= 2487–92 |year= 2005 |pmid= 15728199 |doi= 10.1210/jc.2004-2450 |display-authors=etal}}
*{{cite journal  | author=Thomée C, Schubert SW, Parma J, ''et al.'' |title=GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 5 |pages= 2487-92 |year= 2005 |pmid= 15728199 |doi= 10.1210/jc.2004-2450 }}
*{{cite journal  |vauthors=Baumber L, Tufarelli C, Patel S |title=Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism |journal=J. Med. Genet. |volume=42 |issue= 5 |pages= 443–8 |year= 2006 |pmid= 15863676 |doi= 10.1136/jmg.2004.026898 | pmc=1736051 |display-authors=etal}}
*{{cite journal  | author=Baumber L, Tufarelli C, Patel S, ''et al.'' |title=Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism. |journal=J. Med. Genet. |volume=42 |issue= 5 |pages= 443-8 |year= 2006 |pmid= 15863676 |doi= 10.1136/jmg.2004.026898 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 08:42, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.[1][2]

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM][2]

References

  1. ↑ Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T (Feb 1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene". FEBS Lett. 442 (2–3): 151–6. doi:10.1016/S0014-5793(98)01650-0. PMID 9928992.
  2. ↑ 2.0 2.1 "Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)".

Further reading



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