GADD45B: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Growth arrest and DNA-damage-inducible, beta''', also known as '''GADD45B''', is a [[protein]] which in humans is encoded by the ''GADD45B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GADD45B growth arrest and DNA-damage-inducible, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4616| accessdate = }}</ref><ref name="pmid1899477">{{cite journal | vauthors = Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA | title = Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines | journal = Oncogene | volume = 6 | issue = 1 | pages = 165–7 | date = Jan 1991 | pmid = 1899477 | doi =  }}</ref><ref name="pmid9827804">{{cite journal | vauthors = Takekawa M, Saito H | title = A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK | journal = Cell | volume = 95 | issue = 4 | pages = 521–30 | date = Nov 1998 | pmid = 9827804 | doi = 10.1016/S0092-8674(00)81619-0 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth arrest and DNA-damage-inducible, beta
| HGNCid = 4096
| Symbol = GADD45B
| AltSymbols =; DKFZP566B133; GADD45BETA; MYD118
| OMIM = 604948
| ECnumber = 
| Homologene = 7433
| MGIid = 107776
| GeneAtlas_image1 = PBB_GE_GADD45B_207574_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GADD45B_209304_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_GADD45B_209305_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000185 |text = activation of MAPKKK activity}} {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4616
    | Hs_Ensembl = ENSG00000099860
    | Hs_RefseqProtein = NP_056490
    | Hs_RefseqmRNA = NM_015675
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 2427135
    | Hs_GenLoc_end = 2429257
    | Hs_Uniprot = O75293
    | Mm_EntrezGene = 17873
    | Mm_Ensembl = ENSMUSG00000015312
    | Mm_RefseqmRNA = NM_008655
    | Mm_RefseqProtein = NP_032681
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80333216
    | Mm_GenLoc_end = 80335333
    | Mm_Uniprot = P22339
  }}
}}
'''Growth arrest and DNA-damage-inducible, beta''', also known as '''GADD45B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GADD45B growth arrest and DNA-damage-inducible, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4616| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the [[p38 mitogen-activated protein kinases|p38]]/[[c-Jun N-terminal kinases|JNK]] pathway.  This activation is mediated via their proteins binding and activating MTK1/[[MAP3K4|MEKK4]] kinase, which is an upstream activator of both p38 and JNK [[Mitogen-activated protein kinase|MAPK]]s. The function of these genes or their protein products is involved in the regulation of growth and [[apoptosis]]. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
Gadd45b is required for activity-induced [[DNA demethylation]] of specific [[Promoter (biology)|promoter]]s and expression of corresponding genes necessary for adult [[neurogenesis]], including [[brain-derived neurotrophic factor]] and [[fibroblast growth factor]]. Hence GADD45B is implicated in affecting [[synaptic plasticity]].<ref name="pmid19119186">{{cite journal | vauthors = Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H | title = Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis | journal = Science | volume = 323 | issue = 5917 | pages = 1074–7 | date = Feb 2009 | pmid = 19119186 | pmc = 2726986 | doi = 10.1126/science.1166859 }}</ref>
| summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway.  This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.<ref name="entrez">{{cite web | title = Entrez Gene: GADD45B growth arrest and DNA-damage-inducible, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4616| accessdate = }}</ref>
 
}}
== Interactions ==
==See also==
 
GADD45B has been shown to [[Protein-protein interaction|interact]] with:
* [[ASK1]],<ref name = pmid14743220>{{cite journal | vauthors = Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang WJ, D'Adamio L, Franzoso G | title = Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2 | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 146–53 | date = Feb 2004 | pmid = 14743220 | doi = 10.1038/ncb1093 }}</ref>
* [[GADD45GIP1]],<ref name = pmid12716909>{{cite journal | vauthors = Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M | title = CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle | journal = The Journal of Biological Chemistry | volume = 278 | issue = 30 | pages = 28079–88 | date = Jul 2003 | pmid = 12716909 | doi = 10.1074/jbc.M212835200 }}</ref>
* [[MAP2K7]]<ref name = pmid14743220/> and
* [[MAP3K4]].<ref name = pmid9827804 />
 
== See also ==
*[[Gadd45]]
*[[Gadd45]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA | title = Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines | journal = Oncogene | volume = 6 | issue = 1 | pages = 165–7 | date = Jan 1991 | pmid = 1899477 | doi =  }}
| citations =
* {{cite journal | vauthors = Vairapandi M, Balliet AG, Fornace AJ, Hoffman B, Liebermann DA | title = The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1 | journal = Oncogene | volume = 12 | issue = 12 | pages = 2579–94 | date = Jun 1996 | pmid = 8700517 | doi =  }}
*{{cite journal | author=Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA |title=Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. |journal=Oncogene |volume=6 |issue= 1 |pages= 165-7 |year= 1991 |pmid= 1899477 |doi=  }}
* {{cite journal | vauthors = Koonin EV | title = Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins | journal = Journal of Molecular Medicine | volume = 75 | issue = 4 | pages = 236–8 | date = Apr 1997 | pmid = 9151207 | doi =  }}
*{{cite journal | author=Vairapandi M, Balliet AG, Fornace AJ, ''et al.'' |title=The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. |journal=Oncogene |volume=12 |issue= 12 |pages= 2579-94 |year= 1996 |pmid= 8700517 |doi=  }}
* {{cite journal | vauthors = Takekawa M, Saito H | title = A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK | journal = Cell | volume = 95 | issue = 4 | pages = 521–30 | date = Nov 1998 | pmid = 9827804 | doi = 10.1016/S0092-8674(00)81619-0 }}
*{{cite journal | author=Koonin EV |title=Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins. |journal=J. Mol. Med. |volume=75 |issue= 4 |pages= 236-8 |year= 1997 |pmid= 9151207 |doi=  }}
* {{cite journal | vauthors = Sakaue M, Adachi H, Jetten AM | title = Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis | journal = Molecular Pharmacology | volume = 55 | issue = 4 | pages = 668–76 | date = Apr 1999 | pmid = 10101024 | doi =  }}
*{{cite journal | author=Takekawa M, Saito H |title=A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. |journal=Cell |volume=95 |issue= 4 |pages= 521-30 |year= 1998 |pmid= 9827804 |doi= }}
* {{cite journal | vauthors = Gong R, Yu L, Zhang H, Tu Q, Zhao Y, Yang J, Xu Y, Zhao S | title = Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1-2 | pages = 95–6 | year = 2000 | pmid = 10773677 | doi = 10.1159/000015496 }}
*{{cite journal | author=Sakaue M, Adachi H, Jetten AM |title=Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis. |journal=Mol. Pharmacol. |volume=55 |issue= 4 |pages= 668-76 |year= 1999 |pmid= 10101024 |doi=  }}
* {{cite journal | vauthors = Vairapandi M, Azam N, Balliet AG, Hoffman B, Liebermann DA | title = Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 16810–9 | date = Jun 2000 | pmid = 10828065 | doi = 10.1074/jbc.275.22.16810 }}
*{{cite journal | author=Gong R, Yu L, Zhang H, ''et al.'' |title=Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 95-6 |year= 2000 |pmid= 10773677 |doi= }}
* {{cite journal | vauthors = Yi YW, Kim D, Jung N, Hong SS, Lee HS, Bae I | title = Gadd45 family proteins are coactivators of nuclear hormone receptors | journal = Biochemical and Biophysical Research Communications | volume = 272 | issue = 1 | pages = 193–8 | date = May 2000 | pmid = 10872826 | doi = 10.1006/bbrc.2000.2760 }}
*{{cite journal | author=Vairapandi M, Azam N, Balliet AG, ''et al.'' |title=Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16810-9 |year= 2000 |pmid= 10828065 |doi= }}
* {{cite journal | vauthors = Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW | title = Identification of a functional domain in a GADD45-mediated G2/M checkpoint | journal = The Journal of Biological Chemistry | volume = 275 | issue = 47 | pages = 36892–8 | date = Nov 2000 | pmid = 10973963 | doi = 10.1074/jbc.M005319200 }}
*{{cite journal | author=Yi YW, Kim D, Jung N, ''et al.'' |title=Gadd45 family proteins are coactivators of nuclear hormone receptors. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 193-8 |year= 2000 |pmid= 10872826 |doi= }}
* {{cite journal | vauthors = Wan Y, Wang Z, Shao Y, Xu Y, Voorhees J, Fisher G | title = UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo | journal = International Journal of Molecular Medicine | volume = 6 | issue = 6 | pages = 683–8 | date = Dec 2000 | pmid = 11078829 | doi = 10.3892/ijmm.6.6.683 }}
*{{cite journal | author=Yang Q, Manicone A, Coursen JD, ''et al.'' |title=Identification of a functional domain in a GADD45-mediated G2/M checkpoint. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36892-8 |year= 2001 |pmid= 10973963 |doi= 10.1074/jbc.M005319200 }}
* {{cite journal | vauthors = Kovalsky O, Lung FD, Roller PP, Fornace AJ | title = Oligomerization of human Gadd45a protein | journal = The Journal of Biological Chemistry | volume = 276 | issue = 42 | pages = 39330–9 | date = Oct 2001 | pmid = 11498536 | doi = 10.1074/jbc.M105115200 }}
*{{cite journal | author=Wan Y, Wang Z, Shao Y, ''et al.'' |title=UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo. |journal=Int. J. Mol. Med. |volume=6 |issue= 6 |pages= 683-8 |year= 2001 |pmid= 11078829 |doi= }}
* {{cite journal | vauthors = Vairapandi M, Balliet AG, Hoffman B, Liebermann DA | title = GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress | journal = Journal of Cellular Physiology | volume = 192 | issue = 3 | pages = 327–38 | date = Sep 2002 | pmid = 12124778 | doi = 10.1002/jcp.10140 }}
*{{cite journal | author=Kovalsky O, Lung FD, Roller PP, Fornace AJ |title=Oligomerization of human Gadd45a protein. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39330-9 |year= 2001 |pmid= 11498536 |doi= 10.1074/jbc.M105115200 }}
* {{cite journal | vauthors = Jin R, De Smaele E, Zazzeroni F, Nguyen DU, Papa S, Jones J, Cox C, Gelinas C, Franzoso G | title = Regulation of the gadd45beta promoter by NF-kappaB | journal = DNA and Cell Biology | volume = 21 | issue = 7 | pages = 491–503 | date = Jul 2002 | pmid = 12162804 | doi = 10.1089/104454902320219059 }}
*{{cite journal | author=Vairapandi M, Balliet AG, Hoffman B, Liebermann DA |title=GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. |journal=J. Cell. Physiol. |volume=192 |issue= 3 |pages= 327-38 |year= 2002 |pmid= 12124778 |doi= 10.1002/jcp.10140 }}
* {{cite journal | vauthors = Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M | title = CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle | journal = The Journal of Biological Chemistry | volume = 278 | issue = 30 | pages = 28079–88 | date = Jul 2003 | pmid = 12716909 | doi = 10.1074/jbc.M212835200 }}
*{{cite journal | author=Jin R, De Smaele E, Zazzeroni F, ''et al.'' |title=Regulation of the gadd45beta promoter by NF-kappaB. |journal=DNA Cell Biol. |volume=21 |issue= 7 |pages= 491-503 |year= 2002 |pmid= 12162804 |doi= 10.1089/104454902320219059 }}
* {{cite journal | vauthors = Qiu W, David D, Zhou B, Chu PG, Zhang B, Wu M, Xiao J, Han T, Zhu Z, Wang T, Liu X, Lopez R, Frankel P, Jong A, Yen Y | title = Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma | journal = The American Journal of Pathology | volume = 162 | issue = 6 | pages = 1961–74 | date = Jun 2003 | pmid = 12759252 | pmc = 1868146 | doi = 10.1016/s0002-9440(10)64329-5 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De Smaele E, Peter ME, Franzoso G | title = Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis | journal = Blood | volume = 102 | issue = 9 | pages = 3270–9 | date = Nov 2003 | pmid = 12855571 | doi = 10.1182/blood-2003-03-0689 }}
*{{cite journal | author=Chung HK, Yi YW, Jung NC, ''et al.'' |title=CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28079-88 |year= 2003 |pmid= 12716909 |doi= 10.1074/jbc.M212835200 }}
* {{cite journal | vauthors = Major MB, Jones DA | title = Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5278–87 | date = Feb 2004 | pmid = 14630914 | doi = 10.1074/jbc.M311517200 }}
*{{cite journal | author=Qiu W, David D, Zhou B, ''et al.'' |title=Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. |journal=Am. J. Pathol. |volume=162 |issue= 6 |pages= 1961-74 |year= 2003 |pmid= 12759252 |doi= }}
* {{cite journal | vauthors = Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang WJ, D'Adamio L, Franzoso G | title = Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2 | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 146–53 | date = Feb 2004 | pmid = 14743220 | doi = 10.1038/ncb1093 }}
*{{cite journal | author=Zazzeroni F, Papa S, Algeciras-Schimnich A, ''et al.'' |title=Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. |journal=Blood |volume=102 |issue= 9 |pages= 3270-9 |year= 2004 |pmid= 12855571 |doi= 10.1182/blood-2003-03-0689 }}
*{{cite journal | author=Major MB, Jones DA |title=Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5278-87 |year= 2004 |pmid= 14630914 |doi= 10.1074/jbc.M311517200 }}
*{{cite journal  | author=Papa S, Zazzeroni F, Bubici C, ''et al.'' |title=Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 146-53 |year= 2004 |pmid= 14743220 |doi= 10.1038/ncb1093 }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-19-stub}}
{{WikiDoc Sources}}

Latest revision as of 01:57, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene.[1][2][3]

Function

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.[1]

Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. Hence GADD45B is implicated in affecting synaptic plasticity.[4]

Interactions

GADD45B has been shown to interact with:

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: GADD45B growth arrest and DNA-damage-inducible, beta".
  2. ↑ Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA (Jan 1991). "Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene. 6 (1): 165–7. PMID 1899477.
  3. ↑ 3.0 3.1 Takekawa M, Saito H (Nov 1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK". Cell. 95 (4): 521–30. doi:10.1016/S0092-8674(00)81619-0. PMID 9827804.
  4. ↑ Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H (Feb 2009). "Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis". Science. 323 (5917): 1074–7. doi:10.1126/science.1166859. PMC 2726986. PMID 19119186.
  5. ↑ 5.0 5.1 Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang WJ, D'Adamio L, Franzoso G (Feb 2004). "Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2". Nature Cell Biology. 6 (2): 146–53. doi:10.1038/ncb1093. PMID 14743220.
  6. ↑ Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.

Further reading

  • Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA (Jan 1991). "Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene. 6 (1): 165–7. PMID 1899477.
  • Vairapandi M, Balliet AG, Fornace AJ, Hoffman B, Liebermann DA (Jun 1996). "The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1". Oncogene. 12 (12): 2579–94. PMID 8700517.
  • Koonin EV (Apr 1997). "Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins". Journal of Molecular Medicine. 75 (4): 236–8. PMID 9151207.
  • Takekawa M, Saito H (Nov 1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK". Cell. 95 (4): 521–30. doi:10.1016/S0092-8674(00)81619-0. PMID 9827804.
  • Sakaue M, Adachi H, Jetten AM (Apr 1999). "Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis". Molecular Pharmacology. 55 (4): 668–76. PMID 10101024.
  • Gong R, Yu L, Zhang H, Tu Q, Zhao Y, Yang J, Xu Y, Zhao S (2000). "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 95–6. doi:10.1159/000015496. PMID 10773677.
  • Vairapandi M, Azam N, Balliet AG, Hoffman B, Liebermann DA (Jun 2000). "Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control". The Journal of Biological Chemistry. 275 (22): 16810–9. doi:10.1074/jbc.275.22.16810. PMID 10828065.
  • Yi YW, Kim D, Jung N, Hong SS, Lee HS, Bae I (May 2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors". Biochemical and Biophysical Research Communications. 272 (1): 193–8. doi:10.1006/bbrc.2000.2760. PMID 10872826.
  • Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW (Nov 2000). "Identification of a functional domain in a GADD45-mediated G2/M checkpoint". The Journal of Biological Chemistry. 275 (47): 36892–8. doi:10.1074/jbc.M005319200. PMID 10973963.
  • Wan Y, Wang Z, Shao Y, Xu Y, Voorhees J, Fisher G (Dec 2000). "UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo". International Journal of Molecular Medicine. 6 (6): 683–8. doi:10.3892/ijmm.6.6.683. PMID 11078829.
  • Kovalsky O, Lung FD, Roller PP, Fornace AJ (Oct 2001). "Oligomerization of human Gadd45a protein". The Journal of Biological Chemistry. 276 (42): 39330–9. doi:10.1074/jbc.M105115200. PMID 11498536.
  • Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (Sep 2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress". Journal of Cellular Physiology. 192 (3): 327–38. doi:10.1002/jcp.10140. PMID 12124778.
  • Jin R, De Smaele E, Zazzeroni F, Nguyen DU, Papa S, Jones J, Cox C, Gelinas C, Franzoso G (Jul 2002). "Regulation of the gadd45beta promoter by NF-kappaB". DNA and Cell Biology. 21 (7): 491–503. doi:10.1089/104454902320219059. PMID 12162804.
  • Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.
  • Qiu W, David D, Zhou B, Chu PG, Zhang B, Wu M, Xiao J, Han T, Zhu Z, Wang T, Liu X, Lopez R, Frankel P, Jong A, Yen Y (Jun 2003). "Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma". The American Journal of Pathology. 162 (6): 1961–74. doi:10.1016/s0002-9440(10)64329-5. PMC 1868146. PMID 12759252.
  • Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De Smaele E, Peter ME, Franzoso G (Nov 2003). "Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis". Blood. 102 (9): 3270–9. doi:10.1182/blood-2003-03-0689. PMID 12855571.
  • Major MB, Jones DA (Feb 2004). "Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta". The Journal of Biological Chemistry. 279 (7): 5278–87. doi:10.1074/jbc.M311517200. PMID 14630914.
  • Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang WJ, D'Adamio L, Franzoso G (Feb 2004). "Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2". Nature Cell Biology. 6 (2): 146–53. doi:10.1038/ncb1093. PMID 14743220.
Retrieved from "https://www.wikidoc.org/index.php?title=GADD45B&oldid=1418745"