Fat embolism syndrome laboratory findings: Difference between revisions

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{{Fat embolism syndrome}}
{{Fat embolism syndrome}}


{{CMG}}
{{CMG}} {{AE}} {{FT}}
 
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==Overview==
==Overview==
Laboratory tests are not done commonly to diagnose fat embolism. However, the most commonly seen findings are anemia, thrombocytopenia and lipidura.


==Laboratory Findings==
==Laboratory Findings==


The recovery of fat from pulmonary artery (PA) catheter wedged blood, [[sputum]] and [[urine]] is nonspecific. One study found fat in 50% of sera from patients with long bone fractures who had no evidence of FES.  [[Bronchoscopy]] and [[bronchoalveolar lavage]] (BAL) seem to be more specific by demonstrating fat droplets in alveolar [[macrophages]].
=== Common Laboratory Findings: ===
The most commonly seen laboratory findings in fat embolism include:
* [[Anemia]]
* [[Thrombocytopenia]]
* [[Lipiduria]]
 
In some cases, fat embolism syndrome is associated with elevations in the following laboratory values:<ref name="KaoYeh2007">{{cite journal|last1=Kao|first1=Shang Jyh|last2=Yeh|first2=Diana Yu-Wung|last3=Chen|first3=Hsing I.|title=Clinical and pathological features of fat embolism with acute respiratory distress syndrome|journal=Clinical Science|volume=113|issue=6|year=2007|pages=279–285|issn=0143-5221|doi=10.1042/CS20070011}}</ref><ref name="pmid9108767">{{cite journal| author=Bulger EM, Smith DG, Maier RV, Jurkovich GJ| title=Fat embolism syndrome. A 10-year review. | journal=Arch Surg | year= 1997 | volume= 132 | issue= 4 | pages= 435-9 | pmid=9108767 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9108767 }} </ref>
* Plasma PLA2 (phospholipase A2)
* [[Nitrate]]/nitrite
* Methylguanidine
* [[Tumor necrosis factor-alpha|TNF]](tumour necrosis factor-α)
* IL-1β ([[interleukin]]-1β)
* IL-10 ([[interleukin]]-10)
* IL-6 ([[interleukin]]-6)<ref name="pmid23423626">{{cite journal| author=Prakash S, Sen RK, Tripathy SK, Sen IM, Sharma RR, Sharma S| title=Role of interleukin-6 as an early marker of fat embolism syndrome: a clinical study. | journal=Clin Orthop Relat Res | year= 2013 | volume= 471 | issue= 7 | pages= 2340-6 | pmid=23423626 | doi=10.1007/s11999-013-2869-y | pmc=3676609 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23423626  }} </ref>


==References==
==References==
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[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Orthopedics]]

Latest revision as of 13:56, 6 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Overview

Laboratory tests are not done commonly to diagnose fat embolism. However, the most commonly seen findings are anemia, thrombocytopenia and lipidura.

Laboratory Findings

Common Laboratory Findings:

The most commonly seen laboratory findings in fat embolism include:

In some cases, fat embolism syndrome is associated with elevations in the following laboratory values:[1][2]

References

  1. Kao, Shang Jyh; Yeh, Diana Yu-Wung; Chen, Hsing I. (2007). "Clinical and pathological features of fat embolism with acute respiratory distress syndrome". Clinical Science. 113 (6): 279–285. doi:10.1042/CS20070011. ISSN 0143-5221.
  2. Bulger EM, Smith DG, Maier RV, Jurkovich GJ (1997). "Fat embolism syndrome. A 10-year review". Arch Surg. 132 (4): 435–9. PMID 9108767.
  3. Prakash S, Sen RK, Tripathy SK, Sen IM, Sharma RR, Sharma S (2013). "Role of interleukin-6 as an early marker of fat embolism syndrome: a clinical study". Clin Orthop Relat Res. 471 (7): 2340–6. doi:10.1007/s11999-013-2869-y. PMC 3676609. PMID 23423626.