Fanconi syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

The symptomatic onset of Fanconi syndrome could occur at any age depending on the underlying etiology. Fanconi syndrome due to exogenous compounds toxicity usually develops gradually and in long term exposures and probably occur most commonly in adults age group. Inherited forms of the disease mainly become symptomatic in childhood. Cystinosis is the most common genetic disease accompanying Fanconi syndrome and in almost 95% of cases develops clinical symptoms in the first year of life.

Natural History, Complications, and Prognosis

Natural History

• The symptomatic onset of Fanconi syndrome could occur at any age depending on the underlying etiology.
• inherited forms of the disease including

Complications

• Common complications of [disease name] include:
  • [Complication 1]
  • [Complication 2]
  • [Complication 3]

Prognosis

• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
• Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
• The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
• [Subtype of disease/malignancy] is associated with the most favorable prognosis.
• The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.