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FMRFamide (Phe-Met-Arg-Phe-NH2) is a neuropeptide from a broad family of FMRFamide-related peptides (FaRPs) all sharing an -RFamide sequence at their C-terminus. First identified in Hard clam Mercenaria mercenaria it is thought to play an important role in cardiac activity regulation. In Mercenaria mercenaria, FMRFamide has been isolated and demonstrated to increase both the force and frequency of the heartbeat through a biochemical pathway that is thought to involve the increase of cytoplasmic cAMP in the ventricular region (Higgins et al., 1978).

FMRFamide is an important neuropeptide in several phyla such as Insecta, Nematoda, Mollusca and Annelida[1]. It is the most abundant neuropeptide in endocrine cells of insect alimentary tracts along with allatostatin and tachykinin families, however the neuropeptide’s function is not known. Generally, the neuropeptide is encoded by several genes such as flp-1 through flp-22 in C. elegans. The common precursor of the FaRPs is modified to yield many different neuropeptides all having the same FMRFamide sequence. Moreover, these peptides are not functionally redundant [2].

In invertebrates, the FMFRamide-related peptides are known to affect heart rate, blood pressure, gut motility, feeding behaviour and reproduction. In vertebrates such as mice, they are known to affect opioid receptors resulting in elicitation of naloxone-sensitive antinociception and reduction of morphine-induced antinociception [3].


  1. Oetken M, Bachmann J, Schulte-Oehlmann U, Oehlmann J (2004). "Evidence for endocrine disruption in invertebrates". Int. Rev. Cytol. 236: 1–44. doi:10.1016/S0074-7696(04)36001-8. PMID 15261735.
  2. Li C, Kim K, Nelson LS (1999). "FMRFamide-related neuropeptide gene family in Caenorhabditis elegans". Brain Res. 848 (1–2): 26–34. doi:10.1016/S0006-8993(99)01972-1. PMID 10612695. Unknown parameter |month= ignored (help)
  3. Raffa RB, Connelly CD (1992). "Supraspinal antinociception produced by [D-Met2]-FMRFamide in mice". Neuropeptides. 22 (3): 195–203. doi:10.1016/0143-4179(92)90162-P. PMID 1331846. Unknown parameter |month= ignored (help)

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