FLII: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>JCW-CleanerBot
m (→‎top: task, replaced: Cytoskeleton (Hoboken) → Cytoskeleton)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein flightless-1 homolog''' is a [[protein]] that in humans is encoded by the ''FLII'' [[gene]].<ref name="pmid7825574">{{cite journal |vauthors=Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR | title = The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2 | journal = Am J Hum Genet | volume = 56 | issue = 1 | pages = 175–82 |date=Feb 1995 | pmid = 7825574 | pmc = 1801336 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Flightless I homolog (Drosophila)
| HGNCid = 3750
| Symbol = FLII
| AltSymbols =; FLI; FLIL; Fli1; MGC39265
| OMIM = 600362
| ECnumber = 
| Homologene = 11092
| MGIid = 1342286
| GeneAtlas_image1 = PBB_GE_FLII_222065_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FLII_212024_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_FLII_212025_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2314
    | Hs_Ensembl = ENSG00000177731
    | Hs_RefseqProtein = NP_002009
    | Hs_RefseqmRNA = NM_002018
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 18088880
    | Hs_GenLoc_end = 18102780
    | Hs_Uniprot = Q13045
    | Mm_EntrezGene = 14248
    | Mm_Ensembl = ENSMUSG00000002812
    | Mm_RefseqmRNA = XM_972719
    | Mm_RefseqProtein = XP_977813
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 60530344
    | Mm_GenLoc_end = 60543416
    | Mm_Uniprot = Q3TUY1
  }}
}}
'''Flightless I homolog (Drosophila)''', also known as '''FLII''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = }}</ref>
| summary_text = This gene encodes a protein with a [[gelsolin]]-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.<ref name="pmid24155256">{{cite journal | authors = Ghoshdastider U, Popp D, Burtnick LD, Robinson RC | title = The expanding superfamily of gelsolin homology domain proteins | journal = Cytoskeleton | volume = 70 | issue = 11 | pages = 775–95 | year = 2013 | pmid = 24155256 | doi = 10.1002/cm.21149 }}</ref> The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: FLII flightless I homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2314| accessdate = }}</ref>
}}
}}
==Interactions==
FLII has been shown to [[Protein-protein interaction|interact]] with [[LRRFIP1]]<ref name=pmid9525888>{{cite journal |doi=10.1074/jbc.273.14.7920 |last=Liu |first=Y T |authorlink= |author2=Yin H L |date=Apr 1998 |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies |journal=J. Biol. Chem. |volume=273 |issue=14 |pages=7920–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9525888 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10366446>{{cite journal |last=Fong |first=K S |authorlink= |author2=de Couet H G |date=Jun 1999 |title=Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system |journal=Genomics |volume=58 |issue=2 |pages=146–57 |publisher= |location = UNITED STATES| issn = 0888-7543| pmid = 10366446 |doi = 10.1006/geno.1999.5817 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRAF interacting protein]].<ref name=pmid9671805>{{cite journal |doi=10.1093/nar/26.15.3460 |last=Wilson |first=S A |authorlink= |author2=Brown E C |author3=Kingsman A J |author4=Kingsman S M  |date=Aug 1998 |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I |journal=Nucleic Acids Res. |volume=26 |issue=15 |pages=3460–7 |publisher= |location = ENGLAND| issn = 0305-1048| pmid = 9671805 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=147727 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chen KS, Gunaratne PH, Hoheisel JD, ''et al.'' |title=The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2. |journal=Am. J. Hum. Genet. |volume=56 |issue= 1 |pages= 175-82 |year= 1995 |pmid= 7825574 |doi=  }}
*{{cite journal  |vauthors=Campbell HD, Schimansky T, Claudianos C |title=The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11386–90 |year= 1994 |pmid= 8248259 |doi=10.1073/pnas.90.23.11386  | pmc=47987 |display-authors=etal|bibcode=1993PNAS...9011386C}}
*{{cite journal  | author=Campbell HD, Schimansky T, Claudianos C, ''et al.'' |title=The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11386-90 |year= 1994 |pmid= 8248259 |doi=  }}
*{{cite journal  |vauthors=Campbell HD, Fountain S, Young IG |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46–54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709 |display-authors=etal}}
*{{cite journal  | author=Campbell HD, Fountain S, Young IG, ''et al.'' |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46-54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709 }}
*{{cite journal  |vauthors=Liu YT, Yin HL |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7920–7 |year= 1998 |pmid= 9525888 |doi=10.1074/jbc.273.14.7920 }}
*{{cite journal  | author=Liu YT, Yin HL |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7920-7 |year= 1998 |pmid= 9525888 |doi=  }}
*{{cite journal  |vauthors=Wilson SA, Brown EC, Kingsman AJ, Kingsman SM |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3460–7 |year= 1998 |pmid= 9671805 |doi=10.1093/nar/26.15.3460  | pmc=147727 }}
*{{cite journal  | author=Wilson SA, Brown EC, Kingsman AJ, Kingsman SM |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3460-7 |year= 1998 |pmid= 9671805 |doi=  }}
*{{cite journal  |vauthors=Fong KS, de Couet HG |title=Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. |journal=Genomics |volume=58 |issue= 2 |pages= 146–57 |year= 1999 |pmid= 10366446 |doi= 10.1006/geno.1999.5817 }}
*{{cite journal  | author=Fong KS, de Couet HG |title=Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. |journal=Genomics |volume=58 |issue= 2 |pages= 146-57 |year= 1999 |pmid= 10366446 |doi= 10.1006/geno.1999.5817 }}
*{{cite journal  |vauthors=Davy DA, Campbell HD, Fountain S |title=The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. |journal=J. Cell Sci. |volume=114 |issue= Pt 3 |pages= 549–62 |year= 2001 |pmid= 11171324 |doi=  |display-authors=etal}}
*{{cite journal  | author=Davy DA, Campbell HD, Fountain S, ''et al.'' |title=The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. |journal=J. Cell. Sci. |volume=114 |issue= Pt 3 |pages= 549-62 |year= 2001 |pmid= 11171324 |doi=  }}
*{{cite journal  |vauthors=Campbell HD, Fountain S, McLennan IS |title=Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3518–26 |year= 2002 |pmid= 11971982 |doi=10.1128/MCB.22.10.3518-3526.2002 | pmc=133791  |display-authors=etal}}
*{{cite journal  | author=Campbell HD, Fountain S, McLennan IS, ''et al.'' |title=Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3518-26 |year= 2002 |pmid= 11971982 |doi=  }}
*{{cite journal  |vauthors=Bi W, Yan J, Stankiewicz P |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 | pmc=186594 |display-authors=etal}}
*{{cite journal  | author=Bi W, Yan J, Stankiewicz P, ''et al.'' |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713-28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  |vauthors=Lee YH, Campbell HD, Stallcup MR |title=Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 2103–17 |year= 2004 |pmid= 14966289 |doi=10.1128/MCB.24.5.2103-2117.2004  | pmc=350567 }}
*{{cite journal  | author=Lee YH, Campbell HD, Stallcup MR |title=Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 2103-17 |year= 2004 |pmid= 14966289 |doi=  }}
*{{cite journal  |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Wang T, Chuang TH, Ronni T |title=Flightless I homolog negatively modulates the TLR pathway. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1355–62 |year= 2006 |pmid= 16424162 |doi=  10.4049/jimmunol.176.3.1355|display-authors=etal}}
*{{cite journal  | author=Wang T, Chuang TH, Ronni T, ''et al.'' |title=Flightless I homolog negatively modulates the TLR pathway. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1355-62 |year= 2006 |pmid= 16424162 |doi=  }}
*{{cite journal  |vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Kinsey M, Smith R, Lessnick SL |title=NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. |journal=Mol. Cancer Res. |volume=4 |issue= 11 |pages= 851-9 |year= 2007 |pmid= 17114343 |doi= 10.1158/1541-7786.MCR-06-0090 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-17-stub}}

Latest revision as of 02:31, 20 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.[1][2]

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.[3] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[2]

Interactions

FLII has been shown to interact with LRRFIP1[4][5] and TRAF interacting protein.[6]

References

  1. ↑ Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.
  2. ↑ 2.0 2.1 "Entrez Gene: FLII flightless I homolog (Drosophila)".
  3. ↑ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.
  4. ↑ Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. UNITED STATES. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.
  5. ↑ Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. UNITED STATES. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.
  6. ↑ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. ENGLAND. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=FLII&oldid=1529193"