Extranodal NK-T-cell lymphoma natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
* Extranodal NK | * Extranodal NK-T cell lymphoma almost always shows an extranodal presentation.<ref name=cancer.gov> Extranodal NK-/T-cell lymphoma, nasal type. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd530f/. Accessed on February 04, 2016</ref> | ||
* Some cases may be accompanied by secondary lymph node involvement although rare instances of primary lymph node disease in the absence of extranodal involvement has been reported. | * Some cases may be accompanied by secondary lymph node involvement although rare instances of primary lymph node disease in the absence of extranodal involvement has been reported. | ||
* Extension to adjacent tissues such as the nasopharynx, paranasal sinuses, orbit, oral cavity, palate, and oropharynx are possible. | * Extension to adjacent tissues such as the nasopharynx, paranasal sinuses, orbit, oral cavity, palate, and oropharynx are possible. | ||
* At presentation, the disease is often localized to the upper aerodigestive tract. | * At presentation, the disease is often localized to the upper aerodigestive tract. | ||
* Disseminated disease may have involvement of the lymph nodes, bone marrow and peripheral blood. | * Disseminated disease may have involvement of the lymph nodes, bone marrow and peripheral blood. | ||
==Complications== | |||
Extranodal NK/T-cell lymphoma, nasal type, often develop hemophagocytic syndrome (uncontrolled activation of certain parts of the immune system )<ref name=cancer.gov> Extranodal NK-/T-cell lymphoma, nasal type. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd530f/. Accessed on February 04, 2016</ref> | |||
This condition results in | |||
* Fever | |||
* Hepatosplenomegaly | |||
* Pancytopenia | |||
==References== | ==References== |
Revision as of 20:02, 4 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Natural History
- Extranodal NK-T cell lymphoma almost always shows an extranodal presentation.[1]
- Some cases may be accompanied by secondary lymph node involvement although rare instances of primary lymph node disease in the absence of extranodal involvement has been reported.
- Extension to adjacent tissues such as the nasopharynx, paranasal sinuses, orbit, oral cavity, palate, and oropharynx are possible.
- At presentation, the disease is often localized to the upper aerodigestive tract.
- Disseminated disease may have involvement of the lymph nodes, bone marrow and peripheral blood.
Complications
Extranodal NK/T-cell lymphoma, nasal type, often develop hemophagocytic syndrome (uncontrolled activation of certain parts of the immune system )[1] This condition results in
- Fever
- Hepatosplenomegaly
- Pancytopenia
References
- ↑ 1.0 1.1 Extranodal NK-/T-cell lymphoma, nasal type. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd530f/. Accessed on February 04, 2016