Euthyroid sick syndrome causes: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
 
(12 intermediate revisions by one other user not shown)
Line 2: Line 2:
{{Euthyroid sick syndrome}}
{{Euthyroid sick syndrome}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}}{{Akshun}}
==Overview==
==Overview==
Euthyroid sick syndrome can be caused by any serious [[illness]] which leads to increased level of [[cytokines]], decreased level of [[leptin]], [[Hypermetabolism|hyper-metabolism]], [[iodine]] containing [[contrast medium]], decreased [[protein]] synthesis and decreased level of thyroid-binding globulin. The conditions include *[[sepsis]],[[malignancy]], [[physical trauma|Trauma]], [[surgery]], [[burns]], [[bone marrow transplantation]], [[metabolic disorders]], and other [[Inflammatory]] conditions
Euthyroid sick syndrome can be caused by any serious [[illness]] which leads to increased level of [[cytokines]], decreased level of [[leptin]], [[Hypermetabolism|hyper-metabolism]], decreased [[protein]] synthesis and decreased level of thyroid-binding globulin. The conditions include [[sepsis]], [[malignancy]], [[physical trauma|trauma]], [[surgery]], [[burns]], [[bone marrow transplantation|bone marrow transplantation,]] [[metabolic disorders]], and other [[inflammatory]] conditions.
   
   
==Causes==
==Causes==
Euthyroid sick syndrome can be caused by any serious [[illness]] which leads to increased level of [[cytokines]], decreased level of [[leptin]], [[Hypermetabolism|hyper-metabolism]], [[iodine]] containing [[contrast medium]], decreased [[protein]] synthesis and decreased level of thyroid-binding globulin. The conditions include:<ref name="pmid26677087">{{cite journal |vauthors=Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB |title=Nonthyroidal illnesses syndrome in full-term newborns with sepsis |journal=Arch Endocrinol Metab |volume=59 |issue=6 |pages=528–34 |year=2015 |pmid=26677087 |doi=10.1590/2359-3997000000111 |url=}}</ref><ref name="pmid27403906">{{cite journal |vauthors=Frączek MM, Gackowski A, Przybylik-Mazurek E, Nessler J |title=[The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure] |language=Polish |journal=Pol. Merkur. Lekarski |volume=40 |issue=240 |pages=380–3 |year=2016 |pmid=27403906 |doi= |url=}}</ref>
===Common Causes===
Euthyroid sick syndrome can be caused by any serious [[illness]] which leads to increased level of [[cytokines]], decreased level of [[leptin]], [[Hypermetabolism|hyper-metabolism]], [[iodine]] containing [[contrast medium]], decreased [[protein]] synthesis and decreased level of [[TBG|thyroxin-binding globulin]]. The conditions include:<ref name="pmid26677087">{{cite journal |vauthors=Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB |title=Nonthyroidal illnesses syndrome in full-term newborns with sepsis |journal=Arch Endocrinol Metab |volume=59 |issue=6 |pages=528–34 |year=2015 |pmid=26677087 |doi=10.1590/2359-3997000000111 |url=}}</ref><ref name="pmid27403906">{{cite journal |vauthors=Frączek MM, Gackowski A, Przybylik-Mazurek E, Nessler J |title=[The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure] |language=Polish |journal=Pol. Merkur. Lekarski |volume=40 |issue=240 |pages=380–3 |year=2016 |pmid=27403906 |doi= |url=}}</ref><ref name="pmid9591009">{{cite journal |vauthors=Girvent M, Maestro S, Hernández R, Carajol I, Monné J, Sancho JJ, Gubern JM, Sitges-Serra A |title=Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation |journal=Surgery |volume=123 |issue=5 |pages=560–7 |year=1998 |pmid=9591009 |doi=10.1067/msy.1998.87238 |url=}}</ref>
*[[Sepsis]]
*[[Sepsis]]
*[[Malignancy]]
*[[Malignancy]]
Line 16: Line 17:
*[[Metabolic disorders]]
*[[Metabolic disorders]]
*Other [[Inflammatory]] conditions
*Other [[Inflammatory]] conditions
*Any major condition of
*Any major condition of:
**[[Cardiovascular system]]: [[Myocardial infarction]]
**[[Cardiovascular system]]: [[Myocardial infarction]]
**[[Respiratory system]] : [[Pneumonia]]
**[[Respiratory system]] : [[Pneumonia]]
**[[Genitourinary system]]: [[Chronic renal failure]]
**[[Genitourinary system]]: [[Chronic renal failure]]
**[[Gastrointestinal system]]: [[Cirrhosis]]
**[[Gastrointestinal system]]: [[Cirrhosis]]


 
===Less Common Causes===
*The following table summarize the effect of various drugs on thyroid hormones level.
*The following table summarize the effect of various drugs on thyroid hormones level:
{| class="wikitable"
{| class="wikitable"
! rowspan="2" |↓ Hormone secretion
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |↓ Hormone secretion
! rowspan="2" |↓ T4
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |↓ T4
! rowspan="2" |↓ TSH
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |↓ TSH
! rowspan="2" |↓ 5' monodeiodinase
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |↓ 5' monodeiodinase
! rowspan="2" |'''↑ Breakdown of'''
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |'''↑ Breakdown of'''
'''thyroid hormones'''  
'''thyroid hormones'''  
! colspan="2" |'''Thyroid binding globulin'''
! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |'''Thyroid binding globulin'''
|-
|-  
!Increased
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Increased
!Decreased
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Decreased
|-
|-
|
|
*Lithium<br>   
*[[Lithium]]<br>   
*Amiodarone
*[[Amiodarone]]
|
|
*Aluminum hydroxide <br>   
*[[Aluminium hydroxide|Aluminum hydroxide]] <br>   
*Ferrous sulphate <br>   
*[[Ferrous sulphate]] <br>   
*Sucralfate  
*[[Sucralfate]]
|
|
*Dopamine<br>   
*[[Dopamine]]<br>   
*Octreotide <br>   
*[[Octreotide]] <br>   
*Glucocorticoids<br>   
*[[Glucocorticoids]]<br>   
|
|
*Propylthiouracil<br>
*[[Propylthiouracil]]<br>
*Amiodarone<br>   
*[[Amiodarone]]<br>   
*Propranolol (high dose)
*[[Propranolol]] (high dose)
|
|
*Phenobarbital<br>   
*[[Phenobarbital]]<br>   
*Rifampin <br>   
*[[Rifampin]] <br>   
*Phenytoin <br>   
*[[Phenytoin]] <br>   
*Carbamazepine  
*[[Carbamazepine]]
|
|
*Estrogens <br>   
*[[Estrogens]] <br>   
*Tamoxifen <br>   
*[[Tamoxifen]] <br>   
*Fluorouracil <br>     
*[[Fluorouracil]] <br>     
*Methadone<br>   
*[[Methadone]]<br>   
*Heroin
*[[Heroin]]
|
|
*Androgens<br>   
*[[Androgens]]<br>   
*Anabolic steroids<br>     
*[[Anabolic steroids]]<br>     
*Glucocorticoids <br>   
*[[Glucocorticoids]] <br>   
*Furosemide  <br>   
*[[Furosemide]] <br>   
*Mefenamic acid<br>   
*[[Mefenamic acid]]<br>   
*Salicylates
*[[Salicylates]]
|}
 
==Causes==
 
===Common Causes===
[Disease name] may be caused by:
*[cause1]
*[cause2]
*[cause3]
 
*[Disease name] is caused by an infection with [pathogen name].
*[Pathogen name] is caused by [pathogen name].
===Less Common Causes===
Less common causes of [[disease name]] include:
*[cause1]
*[cause2]
*[cause3]
 
===Genetic Causes===
*[Disease name] is caused by a mutation in the [gene name] gene.
 
===Causes by Organ System===
 
{| style="width:80%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | No underlying causes
|-
|}
|}
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order.
{{columns-list|3|
* Cause 1
* Cause 2
* Cause 3
* Cause 4
* Cause 5
* Cause 6
* Cause 7
* Cause 8
* Cause 9
* Cause 10
}}


==References==
==References==

Latest revision as of 20:34, 16 August 2017

Euthyroid sick syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Euthyroid sick syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography/Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Euthyroid sick syndrome causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Euthyroid sick syndrome causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Euthyroid sick syndrome causes

CDC on Euthyroid sick syndrome causes

Euthyroid sick syndrome causes in the news

Blogs on Euthyroid sick syndrome causes

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Euthyroid sick syndrome causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

Euthyroid sick syndrome can be caused by any serious illness which leads to increased level of cytokines, decreased level of leptin, hyper-metabolism, decreased protein synthesis and decreased level of thyroid-binding globulin. The conditions include sepsis, malignancy, trauma, surgery, burns, bone marrow transplantation, metabolic disorders, and other inflammatory conditions.

Causes

Common Causes

Euthyroid sick syndrome can be caused by any serious illness which leads to increased level of cytokines, decreased level of leptin, hyper-metabolism, iodine containing contrast medium, decreased protein synthesis and decreased level of thyroxin-binding globulin. The conditions include:[1][2][3]

Less Common Causes

  • The following table summarize the effect of various drugs on thyroid hormones level:
↓ Hormone secretion ↓ T4 ↓ TSH ↓ 5' monodeiodinase ↑ Breakdown of

thyroid hormones

Thyroid binding globulin
Increased Decreased

References

  1. ↑ Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB (2015). "Nonthyroidal illnesses syndrome in full-term newborns with sepsis". Arch Endocrinol Metab. 59 (6): 528–34. doi:10.1590/2359-3997000000111. PMID 26677087.
  2. ↑ Frączek MM, Gackowski A, Przybylik-Mazurek E, Nessler J (2016). "[The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure]". Pol. Merkur. Lekarski (in Polish). 40 (240): 380–3. PMID 27403906.
  3. ↑ Girvent M, Maestro S, Hernández R, Carajol I, Monné J, Sancho JJ, Gubern JM, Sitges-Serra A (1998). "Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation". Surgery. 123 (5): 560–7. doi:10.1067/msy.1998.87238. PMID 9591009.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Euthyroid_sick_syndrome_causes&oldid=1342441"