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==Overview==
==Overview==
Common risk factors in the development of essential thrombocytosis are presence of ''[[JAK2]]'' gene mutation, high white cell count >15 x 10<sup>9</sup>/L at diagnosis, previous bone marrow fibrosis, age greater than 60 years and female sex.<ref name="pmid21106990">{{cite journal| author=Beer PA, Erber WN, Campbell PJ, Green AR| title=How I treat essential thrombocythemia. | journal=Blood | year= 2011 | volume= 117 | issue= 5 | pages= 1472-82 | pmid=21106990 | doi=10.1182/blood-2010-08-270033 | pmc=PMC3145107 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21106990  }} </ref>  
Common risk factor in the development of essential thrombocytosis is female sex. Common risk factors in the development of thrombotic complications in patients with essential thrombocytosis are previous history of thrombotic events and age greater than 60 years.<ref name="pmid21106990">{{cite journal| author=Beer PA, Erber WN, Campbell PJ, Green AR| title=How I treat essential thrombocythemia. | journal=Blood | year= 2011 | volume= 117 | issue= 5 | pages= 1472-82 | pmid=21106990 | doi=10.1182/blood-2010-08-270033 | pmc=PMC3145107 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21106990  }} </ref>


==Risk factors==
==Risk factors==
*Most common risk factor in the development of essential thrombocytosis is age greater than 60 years.<ref name="pmid21106990">{{cite journal| author=Beer PA, Erber WN, Campbell PJ, Green AR| title=How I treat essential thrombocythemia. | journal=Blood | year= 2011 | volume= 117 | issue= 5 | pages= 1472-82 | pmid=21106990 | doi=10.1182/blood-2010-08-270033 | pmc=PMC3145107 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21106990  }} </ref> Most patients go undiagnosed until late.
*Most common risk factor in the development of essential thrombocytosis is female sex. There is a two fold increased risk in female individuals.<ref name="pmid21106990">{{cite journal| author=Beer PA, Erber WN, Campbell PJ, Green AR| title=How I treat essential thrombocythemia. | journal=Blood | year= 2011 | volume= 117 | issue= 5 | pages= 1472-82 | pmid=21106990 | doi=10.1182/blood-2010-08-270033 | pmc=PMC3145107 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21106990  }} </ref> Most patients remain undiagnosed for a long time.
*Other risk factors for essential thrombocytosis include:
*Risk factors for thrombotic events in patients with essential thrombocytosis may include:<ref name="pmid21106990">{{cite journal| author=Beer PA, Erber WN, Campbell PJ, Green AR| title=How I treat essential thrombocythemia. | journal=Blood | year= 2011 | volume= 117 | issue= 5 | pages= 1472-82 | pmid=21106990 | doi=10.1182/blood-2010-08-270033 | pmc=PMC3145107 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21106990  }} </ref>
**Presence of ''[[JAK2]]'' mutation
**High white cell count of 15 x 10<sup>9</sup>/L at the time of diagnosis
**Previous history of thrombotic events
**Previous history of thrombotic events
**Previous history of [[bone marrow]] fibrosis
**Age greater than 60 years
**Female sex


==References==
==References==

Revision as of 18:43, 23 December 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Common risk factor in the development of essential thrombocytosis is female sex. Common risk factors in the development of thrombotic complications in patients with essential thrombocytosis are previous history of thrombotic events and age greater than 60 years.[1]

Risk factors

  • Most common risk factor in the development of essential thrombocytosis is female sex. There is a two fold increased risk in female individuals.[1] Most patients remain undiagnosed for a long time.
  • Risk factors for thrombotic events in patients with essential thrombocytosis may include:[1]
    • Previous history of thrombotic events
    • Age greater than 60 years

References

  1. 1.0 1.1 1.2 Beer PA, Erber WN, Campbell PJ, Green AR (2011). "How I treat essential thrombocythemia". Blood. 117 (5): 1472–82. doi:10.1182/blood-2010-08-270033. PMC 3145107. PMID 21106990.


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