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{{Infobox_gene}}
{{PBB_Controls
'''Endoplasmic reticulum protein 29''' ('''ERp29''') is a [[chaperone protein]] that in humans is encoded by the ''ERP29'' [[gene]].<ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ERP29_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1g7e.
| PDB = {{PDB2|1g7e}}
| Name = Endoplasmic reticulum protein 29
| HGNCid = 13799
| Symbol = ERP29
| AltSymbols =; C12orf8; ERp28; ERp31; PDI-DB
| OMIM = 602287
| ECnumber = 
| Homologene = 4963
| MGIid = 1914647
| GeneAtlas_image1 = PBB_GE_ERP29_201216_at_tn.png
| Function = {{GNF_GO|id=GO:0003756 |text = protein disulfide isomerase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0009306 |text = protein secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10961
    | Hs_Ensembl = ENSG00000089248
    | Hs_RefseqProtein = NP_001029197
    | Hs_RefseqmRNA = NM_001034025
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 110935535
    | Hs_GenLoc_end = 110945407
    | Hs_Uniprot = P30040
    | Mm_EntrezGene = 67397
    | Mm_Ensembl = ENSMUSG00000029616
    | Mm_RefseqmRNA = NM_026129
    | Mm_RefseqProtein = NP_080405
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 121705368
    | Mm_GenLoc_end = 121713091
    | Mm_Uniprot = P57759
  }}
}}
'''Endoplasmic reticulum protein 29''' ('''ERp29''') is a human [[chaperone protein]]. '''ERP29''' is the human [[gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: ERP29 endoplasmic reticulum protein 29| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10961| accessdate = }}</ref>


==Gene==
ERp29 is a reticuloplasmin, a protein which resides in the lumen of the [[endoplasmic reticulum]] (ER). The protein shows sequence similarity to the [[protein disulfide-isomerase]] family.<ref name="humgenomics.com">{{cite journal | vauthors = Galligan JJ, Petersen DR | title = The human protein disulfide isomerase gene family | journal = Human Genomics | volume = 6 | pages =  6| date = July 2012 | pmid = 23245351 | pmc = 3500226 | doi = 10.1186/1479-7364-6-6 | url = http://www.humgenomics.com/content/6/1/6 | issue=1}}</ref> However, it lacks the [[thioredoxin]] motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase.<ref name="humgenomics.com"/> The protein dimerizes and is thought to play a role in the processing of [[secretory protein]]s within the ER. Alternative splicing results in multiple transcript variants encoding different [[protein isoform|isoforms]].<ref name="entrez">{{cite web | title = Entrez Gene: ERP29 endoplasmic reticulum protein 29| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10961| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: ERP29 endoplasmic reticulum protein 29| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10961| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hubbard MJ | title = Functional proteomics: The goalposts are moving | journal = Proteomics | volume = 2 | issue = 9 | pages = 1069–78 | date = Sep 2002 | pmid = 12362325 | doi = 10.1002/1615-9861(200209)2:9<1069::AID-PROT1069>3.0.CO;2-R }}
| citations =
* {{cite journal | vauthors = Mkrtchian S, Sandalova T | title = ERp29, an unusual redox-inactive member of the thioredoxin family | journal = Antioxidants & Redox Signaling | volume = 8 | issue = 3–4 | pages = 325–37 | year = 2006 | pmid = 16677078 | doi = 10.1089/ars.2006.8.325 }}
*{{cite journal | author=Hubbard MJ |title=Functional proteomics: The goalposts are moving. |journal=Proteomics |volume=2 |issue= 9 |pages= 1069-78 |year= 2003 |pmid= 12362325 |doi= 10.1002/1615-9861(200209)2:9<1069::AID-PROT1069>3.0.CO;2-R }}
* {{cite journal | vauthors = Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R | title = Human liver protein map: a reference database established by microsequencing and gel comparison | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 992–1001 | date = Dec 1992 | pmid = 1286669 | doi = 10.1002/elps.11501301201 }}
*{{cite journal | author=Mkrtchian S, Sandalova T |title=ERp29, an unusual redox-inactive member of the thioredoxin family. |journal=Antioxid. Redox Signal. |volume=8 |issue= 3-4 |pages= 325-37 |year= 2006 |pmid= 16677078 |doi= 10.1089/ars.2006.8.325 }}
* {{cite journal | vauthors = Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF | title = Human liver protein map: update 1993 | journal = Electrophoresis | volume = 14 | issue = 11 | pages = 1216–22 | date = Nov 1993 | pmid = 8313870 | doi = 10.1002/elps.11501401181 }}
*{{cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992-1001 |year= 1993 |pmid= 1286669 |doi= }}
* {{cite journal | vauthors = Mkrtchian S, Fang C, Hellman U, Ingelman-Sundberg M | title = A stress-inducible rat liver endoplasmic reticulum protein, ERp29 | journal = European Journal of Biochemistry / FEBS | volume = 251 | issue = 1–2 | pages = 304–13 | date = Jan 1998 | pmid = 9492298 | doi = 10.1046/j.1432-1327.1998.2510304.x }}
*{{cite journal | author=Hughes GJ, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: update 1993. |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216-22 |year= 1994 |pmid= 8313870 |doi= }}
* {{cite journal | vauthors = Ferrari DM, Nguyen Van P, Kratzin HD, Söling HD | title = ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif | journal = European Journal of Biochemistry / FEBS | volume = 255 | issue = 3 | pages = 570–9 | date = Aug 1998 | pmid = 9738895 | doi = 10.1046/j.1432-1327.1998.2550570.x }}
*{{cite journal | author=Mkrtchian S, Fang C, Hellman U, Ingelman-Sundberg M |title=A stress-inducible rat liver endoplasmic reticulum protein, ERp29. |journal=Eur. J. Biochem. |volume=251 |issue= 1-2 |pages= 304-13 |year= 1998 |pmid= 9492298 |doi= }}
* {{cite journal | vauthors = Hubbard MJ, McHugh NJ | title = Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping | journal = Electrophoresis | volume = 21 | issue = 17 | pages = 3785–96 | date = Nov 2000 | pmid = 11271497 | doi = 10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2 }}
*{{cite journal | author=Ferrari DM, Nguyen Van P, Kratzin HD, Söling HD |title=ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif. |journal=Eur. J. Biochem. |volume=255 |issue= 3 |pages= 570-9 |year= 1998 |pmid= 9738895 |doi= }}
* {{cite journal | vauthors = Shnyder SD, Hubbard MJ | title = ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production | journal = The Journal of Histochemistry and Cytochemistry | volume = 50 | issue = 4 | pages = 557–66 | date = Apr 2002 | pmid = 11897809 | doi = 10.1177/002215540205000413 }}
*{{cite journal | author=Hubbard MJ, McHugh NJ |title=Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping. |journal=Electrophoresis |volume=21 |issue= 17 |pages= 3785-96 |year= 2001 |pmid= 11271497 |doi= 10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2 }}
* {{cite journal | vauthors = Sargsyan E, Baryshev M, Backlund M, Sharipo A, Mkrtchian S | title = Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29 | journal = Gene | volume = 285 | issue = 1–2 | pages = 127–39 | date = Feb 2002 | pmid = 12039039 | doi = 10.1016/S0378-1119(02)00417-1 }}
*{{cite journal | author=Shnyder SD, Hubbard MJ |title=ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production. |journal=J. Histochem. Cytochem. |volume=50 |issue= 4 |pages= 557-66 |year= 2002 |pmid= 11897809 |doi= }}
* {{cite journal | vauthors = Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E | title = Proteomic analysis of early melanosomes: identification of novel melanosomal proteins | journal = Journal of Proteome Research | volume = 2 | issue = 1 | pages = 69–79 | year = 2003 | pmid = 12643545 | doi = 10.1021/pr025562r }}
*{{cite journal | author=Sargsyan E, Baryshev M, Backlund M, ''et al.'' |title=Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29. |journal=Gene |volume=285 |issue= 1-2 |pages= 127-39 |year= 2002 |pmid= 12039039 |doi= }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, Mkrtchian S, Koutselini H | title = Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma | journal = The American Journal of Dermatopathology | volume = 28 | issue = 5 | pages = 410–2 | date = Oct 2006 | pmid = 17012915 | doi = 10.1097/01.dad.0000211521.49810.ac }}
*{{cite journal | author=Basrur V, Yang F, Kushimoto T, ''et al.'' |title=Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. |journal=J. Proteome Res. |volume=2 |issue= 1 |pages= 69-79 |year= 2003 |pmid= 12643545 |doi=  }}
* {{cite journal | vauthors = Zheng J, Liu X, Yan X, Dai L, Ji C | title = Purification and structural characterization of human ERp29 | journal = Protein and Peptide Letters | volume = 13 | issue = 8 | pages = 753–9 | year = 2006 | pmid = 17073718 | doi = 10.2174/092986606777841190 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF | title = Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes | journal = Journal of Proteome Research | volume = 5 | issue = 11 | pages = 3135–44 | date = Nov 2006 | pmid = 17081065 | doi = 10.1021/pr060363j }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
* {{cite journal | vauthors = Lippert U, Diao D, Barak NN, Ferrari DM | title = Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones | journal = The Journal of Biological Chemistry | volume = 282 | issue = 15 | pages = 11213–20 | date = Apr 2007 | pmid = 17296603 | doi = 10.1074/jbc.M604440200 }}
*{{cite journal | author=Cheretis C, Dietrich F, Chatzistamou I, ''et al.'' |title=Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma. |journal=The American Journal of dermatopathology |volume=28 |issue= 5 |pages= 410-2 |year= 2007 |pmid= 17012915 |doi= 10.1097/01.dad.0000211521.49810.ac }}
*{{cite journal | author=Zheng J, Liu X, Yan X, ''et al.'' |title=Purification and structural characterization of human ERp29. |journal=Protein Pept. Lett. |volume=13 |issue= 8 |pages= 753-9 |year= 2006 |pmid= 17073718 |doi= }}
*{{cite journal | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal | author=Lippert U, Diao D, Barak NN, Ferrari DM |title=Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones. |journal=J. Biol. Chem. |volume=282 |issue= 15 |pages= 11213-20 |year= 2007 |pmid= 17296603 |doi= 10.1074/jbc.M604440200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=10961}}
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{{gene-12-stub}}

Revision as of 02:13, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein that in humans is encoded by the ERP29 gene.[1]

Function

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family.[2] However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase.[2] The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ERP29 endoplasmic reticulum protein 29".
  2. ↑ 2.0 2.1 Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading

  • Hubbard MJ (Sep 2002). "Functional proteomics: The goalposts are moving". Proteomics. 2 (9): 1069–78. doi:10.1002/1615-9861(200209)2:9<1069::AID-PROT1069>3.0.CO;2-R. PMID 12362325.
  • Mkrtchian S, Sandalova T (2006). "ERp29, an unusual redox-inactive member of the thioredoxin family". Antioxidants & Redox Signaling. 8 (3–4): 325–37. doi:10.1089/ars.2006.8.325. PMID 16677078.
  • Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (Dec 1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
  • Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF (Nov 1993). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870.
  • Mkrtchian S, Fang C, Hellman U, Ingelman-Sundberg M (Jan 1998). "A stress-inducible rat liver endoplasmic reticulum protein, ERp29". European Journal of Biochemistry / FEBS. 251 (1–2): 304–13. doi:10.1046/j.1432-1327.1998.2510304.x. PMID 9492298.
  • Ferrari DM, Nguyen Van P, Kratzin HD, Söling HD (Aug 1998). "ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif". European Journal of Biochemistry / FEBS. 255 (3): 570–9. doi:10.1046/j.1432-1327.1998.2550570.x. PMID 9738895.
  • Hubbard MJ, McHugh NJ (Nov 2000). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping". Electrophoresis. 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497.
  • Shnyder SD, Hubbard MJ (Apr 2002). "ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production". The Journal of Histochemistry and Cytochemistry. 50 (4): 557–66. doi:10.1177/002215540205000413. PMID 11897809.
  • Sargsyan E, Baryshev M, Backlund M, Sharipo A, Mkrtchian S (Feb 2002). "Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29". Gene. 285 (1–2): 127–39. doi:10.1016/S0378-1119(02)00417-1. PMID 12039039.
  • Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". Journal of Proteome Research. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, Mkrtchian S, Koutselini H (Oct 2006). "Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma". The American Journal of Dermatopathology. 28 (5): 410–2. doi:10.1097/01.dad.0000211521.49810.ac. PMID 17012915.
  • Zheng J, Liu X, Yan X, Dai L, Ji C (2006). "Purification and structural characterization of human ERp29". Protein and Peptide Letters. 13 (8): 753–9. doi:10.2174/092986606777841190. PMID 17073718.
  • Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Lippert U, Diao D, Barak NN, Ferrari DM (Apr 2007). "Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones". The Journal of Biological Chemistry. 282 (15): 11213–20. doi:10.1074/jbc.M604440200. PMID 17296603.


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