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'''Docusate''' ({{pronEng|ˈdɒkjuːseɪt}}) is the generic name of a [[surfactant]] used as a [[laxative]] and [[stool softener]], which is sold in the U.S. under multiple brand names: Aqualax, Calube, Colace, Colace Micro-Enema, Correctol Softgel Extra Gentle, DC-240, Dialose, Diocto, Dioctocal, Dioctosoftez, Dioctyn, Dionex, Doc-Q-Lace, Docu Soft, Docucal, Doculax, Docusoft S, DOK, DOS, Doss-Relief, DSS, Dulcolax, Ex-Lax Stool Softener, Fleet Sof-Lax, Genasoft, Kasof, Laxa-basic, Modane Soft, Octycine-100, Regulax SS, Sulfalax Calcium, Sur-Q-Lax, Surfak Stool Softener and Therevac-SB.
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Docusate is also any of a group of anionic surfactants widely used as emulsifying, wetting, and dispersing agents.
* Content


==Clinical use==
<!--Adult Indications and Dosage-->


Docusate is given to make stools softer and easier to pass.  It is used to treat [[constipation]] due to hard stools, in painful anorectal conditions such as [[hemorrhoids]], and for people who should avoid straining during bowel movements.  Of note is that the effect of docusate may not necessarily be all due to its surfactant properties.  [[Perfusion]] studies suggest that docusates inhibit fluid absorption or stimulate secretion in jejunum.
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====


While the use of docusate is widespread, the data to support its efficacy in treating chronic constipation is actually lacking.  Also, although more research is needed, long term use of docusate seems to decrease levels of magnesium and potassium in the blood.
* Dosing Information


Docusate should not be used in addition to mineral oil as the emulsifier will result in mineral oil being absorbed rather than functioning as a lubricant for the bowel walls.
:* Dosage


==Presentations==
=====Condition2=====
*Docusate is available in tablet, [[capsule]], liquid, and rectal [[enema]].
*Docusate calcium [USP] and docusate potassium [USP] are anionic surfactants used as stool softeners and are administered orally.
*Docusate sodium [USP] is anionic surfactant used as a stool softener and is administered orally or rectally; as a tablet disintegrant or as an emulsifier and dispersant in topical preparations.  When sold as Colace, it is docusate sodium, or sodium salt of [[dioctyl]] [[sodium sulfosuccinate]] (DSS).  Some metabolism studies show that DSS is absorbed by the body from the gastrointestinal tract, undergoing extensive metabolism.  In humans, the main way DSS metabolites are excreted is via the feces.


Docusate sodium may be used in a daily regimine in persons who are undergoing narcotic pain medication therapy to reduce the effects of chronic constipation or hardened stools which can cause severe straining, impaction, and torn rectal tissues.
* Dosing Information


==Effect==
:* Dosage
*The effect on stools is seen 1 to 3 days after the first dose.


{{Laxatives}}
=====Condition3=====


[[Category:Laxatives]]
* Dosing Information


{{pharma-stub}}
:* Dosage
 
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* Dosing Information
 
:* Dosage
 
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[[Category:Drug]]

Revision as of 14:28, 21 February 2015

Docusate
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Docusate is a {{{drugClass}}} that is FDA approved for the treatment of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Docusate in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Docusate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Docusate in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Docusate in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Docusate in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Docusate in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Docusate in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Docusate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Docusate during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Docusate with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Docusate with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Docusate with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Docusate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Docusate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Docusate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Docusate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Docusate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Docusate in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Docusate in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Docusate in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Docusate in the drug label.

Pharmacology

There is limited information regarding Docusate Pharmacology in the drug label.

Mechanism of Action

Structure

File:Docusate01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Docusate in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Docusate in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Docusate in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Docusate in the drug label.

How Supplied

Storage

There is limited information regarding Docusate Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Docusate |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Docusate |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Docusate in the drug label.

Precautions with Alcohol

  • Alcohol-Docusate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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