Diphyllobothriasis medical therapy: Difference between revisions

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#*Oral [[praziquantel]] is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
#*Oral [[praziquantel]] is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
#Niclosamide
#Niclosamide
#*Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.
#*[[Niclosamide]] inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.


==References==
==References==

Revision as of 19:56, 28 June 2017

Diphyllobothriasis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Furqan M M. M.B.B.S[3]

Overview

Drugs used for diphyllobothriasis include either praziquantel or niclosamide.

Medical Therapy

The medications used in the treatment of diphyllobothriasis are:

Antimicrobial Regimen

Shown below is a table summarizing the preferred and alternative empiric treatment for Diphyllobothriasis[1]

Pathogens Preferred Treatment Duration of Treatment Alternative Treatment
Diphyllobothrium latum Praziquantel*

Adults, 5-10 mg/kg orally in a single-dose therapy; the dosage for children is the same.

Single dose Niclosamide

Adult 2 gm orally once; children, 50 mg/kg (max 2 gm) orally once.

Mechanism of action

  1. Praziquantel
    • Oral praziquantel is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
  2. Niclosamide
    • Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.

References

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