Digitoxin

Revision as of 21:29, 23 July 2014 by GeraldChi (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Digitoxin
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC41H64O13
Molar mass764.939 g/mol

WikiDoc Resources for Digitoxin

Articles

Most recent articles on Digitoxin

Most cited articles on Digitoxin

Review articles on Digitoxin

Articles on Digitoxin in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Digitoxin

Images of Digitoxin

Photos of Digitoxin

Podcasts & MP3s on Digitoxin

Videos on Digitoxin

Evidence Based Medicine

Cochrane Collaboration on Digitoxin

Bandolier on Digitoxin

TRIP on Digitoxin

Clinical Trials

Ongoing Trials on Digitoxin at Clinical Trials.gov

Trial results on Digitoxin

Clinical Trials on Digitoxin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Digitoxin

NICE Guidance on Digitoxin

NHS PRODIGY Guidance

FDA on Digitoxin

CDC on Digitoxin

Books

Books on Digitoxin

News

Digitoxin in the news

Be alerted to news on Digitoxin

News trends on Digitoxin

Commentary

Blogs on Digitoxin

Definitions

Definitions of Digitoxin

Patient Resources / Community

Patient resources on Digitoxin

Discussion groups on Digitoxin

Patient Handouts on Digitoxin

Directions to Hospitals Treating Digitoxin

Risk calculators and risk factors for Digitoxin

Healthcare Provider Resources

Symptoms of Digitoxin

Causes & Risk Factors for Digitoxin

Diagnostic studies for Digitoxin

Treatment of Digitoxin

Continuing Medical Education (CME)

CME Programs on Digitoxin

International

Digitoxin en Espanol

Digitoxin en Francais

Business

Digitoxin in the Marketplace

Patents on Digitoxin

Experimental / Informatics

List of terms related to Digitoxin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Digitoxin is a cardiac glycoside. It has similar structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current Western medical practice. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.[1]

Toxicity

Digitoxin exhibits similar toxic effects to the more commonly used digoxin, namely: anorexia, nausea, vomiting, diarrhea, confusion, visual disturbances, and cardiac arrhythmias. Antidigoxin antibody fragments, the specific treatment for digoxin poisoning, are also effective in serious digitoxin toxicity.[2]

History

The first description of the use of foxglove dates back to 1775.[3] For quite some time, the active compound was not isolated. Oswald Schmiedeberg was able to obtain a pure sample in 1875. The modern therapeutic use of this molecule was made possible by the works of the pharmacist and the French chemist Claude-Adolphe Nativelle (1812-1889). The first structural analysis was done by Adolf Otto Reinhold Windaus in 1925, but the full structure with an exact determination of the sugar groups was not accomplished until 1962.[4][5]

References

  1. Belz, G. G.; Breithaupt-Grögler, K.; Osowski, U. (2001). "Treatment of congestive heart failure—current status of use of digitoxin". European Journal of Clinical Investigation. 31 (Suppl 2): 10–17. doi:10.1046/j.1365-2362.2001.0310s2010.x. PMID 11525233.
  2. Kurowski, V.; Iven, H.; Djonlagic, H. (1992). "Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies". Intensive Care Medicine. 18 (7): 439–442. doi:10.1007/BF01694351. PMID 1469187.
  3. Withering, William (1785). An Account of the Foxglove and Some of its Medical Uses: With Practical Remarks on Dropsy and other Diseases.
  4. PMID 18127991 (PMID 18127991)
    Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
  5. Sneader, Walter (2005). Drug discovery: A history. p. 107. ISBN 978-0-471-89980-8.

Template:Glycosides Template:Cardiac glycosides