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| | | #redirect:[[Desogestrel and Ethinyl Estradiol]] |
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| {{drugbox
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| | IUPAC_name = 13-ethyl-17-ethynyl- 11-methylidene- 1,2,3,6,7,8,9,10,12,13,14,15, 16,17- tetradecahydrocyclopenta[a] phenanthren-17-ol
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| | image = Desogestrel.svg
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| | CAS_number = 54024-22-5
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| | ATC_prefix = G03
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| | ATC_suffix = AC09
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| | ATC_supplemental =
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| | PubChem = 40973
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| | DrugBank = APRD00762
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| | C = 22 | H = 30 | O = 1
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| | molecular_weight = 310.473 g/mol
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| | bioavailability =
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| | protein_bound = 98.3%
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| | metabolism =
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| | elimination_half-life =
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| | excretion =
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = <!-- A / B / C / D / X -->
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| | pregnancy_category =
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| | legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
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| | legal_UK = <!-- GSL / P / POM / CD -->
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| | legal_US = <!-- OTC / Rx-only -->
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| | legal_status =
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| | routes_of_administration =
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| }}
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| {{SI}}
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| '''Desogestrel''' is a molecule used in [[hormonal]] [[contraceptives]].
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| ==Controversy==
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| In February of 2007, the consumer adovcacy group Public Citizen released a petition requesting that the [[Food and Drug Administration|FDA]] ban oral contraceptives containing desogestrel, citing studies going as far back as 1995 that suggest the risk of dangerous [[thrombus|blood clots]] is doubled for women on such pills in comparison to other oral contraceptives.
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| Most [[combined oral contraceptive pill]]s (COCPs, or simply OCs) on the market today contain both an estrogen compound ([[ethinyl estradiol]] is common) plus a [[progestin]] (a [[progesterone]]-like compound) such as desogestrel.
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| As such, desogestrel-containing birth control pills are sometimes referred to as "third generation" oral contraceptives. Drugs cited specifically in the petition include Apri-28, [[Cyclessa]], [[Desogen]], [[Kariva]], [[Mircette]], [[Ortho-Cept]], Reclipsen, [[Velivet]] and some generic pills. Birth control pills that are considered "second generation" ([[Ortho Tri-Cyclen]], for example) contain an [[estrogen]] and a [[progestin]], but the [[progestin]] is different, such as [[levonorgestrel]].
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| The dispute is whether third generation OCs are less safe than the second generations OCs, which are considered the current "gold standard" in terms of oral contraceptive safety.
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| ==See also==
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| * [[Progestin]]
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| ==References==
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| * Public Citizen’s Health Research Group: [http://www.citizen.org/publications/release.cfm?ID=7503 Petition to the U.S. Food and Drug Administration to Ban Third Generation Oral Contraceptives Containing Desogestrel due to Increased Risk of Venous Thrombosis] HRG Publication #1799, 2007
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| {{Sex hormones}}
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| [[Category:Hormonal contraception]]
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| [[Category:Progestagens]]
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| [[Category:Endocrinology]]
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| [[de:Desogestrel]]
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| [[tr:Desogestrel]] | |
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