Dermatofibroma overview: Difference between revisions
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In rare cases, [[basal cell carcinoma]] may develop in a dermatofibroma. | |||
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Revision as of 15:39, 28 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Dermatofibromas are harmless benign skin growths, found especially on the legs, that range in size from about 0.5 to 1 cm. Dermatofibromas are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan; they are often elevated or pedunculated.
Historical Perspective
Classification
Dermatofibromas are classed as benign skin lesions, meaning that they are completely harmless, though they may be confused with a variety of subcutaneous tumours. Deep penetrating dermatofibromas may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.
Pathophysiology
Dermatofibromas are composed of disordered collagen laid down by fibroblasts.
Differential Diagnosis
Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumors e.g dermatofibrosarcoma protuberans[1]
Epidemiology and Demographics
Dermatofibromas occur most often in women; the male to female ratio is about 1:4. The age group in which they most commonly occur is twenty to forty-five years.
Risk Factors
The risk factors for development of dermatofibroma include:
- Thorn prick
- Insect bite
Complications
In rare cases, basal cell carcinoma may develop in a dermatofibroma.
History and symptoms
Physical Examination
Biopsy
Treatment
Surgery
- ↑ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Arch. Pathol. Lab. Med. 130 (6): 831–4. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036. Unknown parameter
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