DVT complete diagnostic approach resident survival guide: Difference between revisions

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{{familytree/start}}
==Complete Diagnostic Approach==
{{familytree | | | | | | | | | | | | | | | | A00 | | | | | A00= '''Does the patient who is suspected to have PE have [[hypotension]] or [[shock]]?'''}}
A complete diagnostic approach should be carried out after a focused initial rapid evaluation is conducted and following initiation of any urgent intervention.<ref name="pmid22315267">{{cite journal| author=Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD et al.| title=Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. | journal=Chest | year= 2012 | volume= 141 | issue= 2 Suppl | pages= e351S-418S | pmid=22315267 | doi=10.1378/chest.11-2299 | pmc=PMC3278048 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22315267  }} </ref>
{{familytree | | | | | | | |,|-|-|-|-|-|-|-|-|^|-|-|-|-|-|-|-|-|-|.| }}
 
{{familytree | | | | | | | A01 | | | | | | | | | | | | | | | | | A02 A01= Yes| A02= No}}
<span style="font-size:85%">  </span>
{{familytree | | | | | | | |!| | | | | | | | | | | | | | | | | | |!| }}
 
{{familytree | | | | | | | A02 | | | | | | | | | | | | | | | | | A03 |  A02= '''Suspected high-risk PE'''| A03= '''Suspected non-high risk PE'''}}
{{Family tree/start}}
{{familytree | | | | | | | |!| | | | | | | | | | | | | | | | | | |!| }}
{{familytree  | | | | | | | A01 | | A01=<div style="float: left; text-align: left; width: 35em; padding:1em;"> '''Characterize the symptoms in the involved extremity:''' <br>
{{familytree | | | | | | | A04 | | | | | | | | | | | | | | | | | |!| A04= ''Administer [[anticoagulation]]'' <br>''(in case there are no contraindications)''<br>''during the diagnostic workup''}}
❑ Swelling <br>
{{familytree | | | | | | | |!| | | | | | | | | | | | | | | | | | |!| }}
❑ Pain <br>
{{familytree | | | | | | | B01 | | | | | | | | | | | | | | | | | B02| B01= '''Is a [[CT]] available immediately?'''| B02= '''What is the pretest probability of PE?''' <br> Assess the pretest probability of PE<br> by using one of the risk score:<br> - [[Wells score]] <br> - [[Geneva score]] <br> - [[PERC]]}}
❑ Erythema <br>
{{familytree | | | |,|-|-|-|^|-|-|-|-|-|-|-|.| | | | | | |,|-|v|-|^|-|-|.| | }}
❑ Warmth<br></div>}}
{{familytree | | | C01 | | | | | | | | | | C02 | | | | | |!| |!| | | | |!| | C01= No| C02= Yes}}
{{familytree  | | | | | | | |!| | |}}
{{familytree | | | |!| | | | | | | | | | | |!| | | | | | |!| |!| | | | |!| | }}
{{familytree | | | | | | | B01 | |  B01=
{{familytree | | | D01 | | | | | | | | | | |!| | | | | | |!| |!| | | | |!| | D01= '''Order [[echocardiography]]'''}}
<div style="float: left; text-align: left; width: 35em; padding:1em;">
{{familytree | | | |!| | | | | | | | | | | |!| | | | | | |!| |!| | | | |!| | }}
'''Identify possible precipitating factors:'''<br>
{{familytree | | | E01 | | | | | | | | | | |!| | | | | E02 | | E03 | | E04 |  E01= '''Does the patient have [[RV]] overload?'''| E02= '''Low pretest probability''' |E03= '''Intermediate pretest probability'''| E04= '''High pretest probability''' <br>OR<br> '''PE is likely'''}}
❑ Recent surgery <br>
{{familytree | | | |!| | | | | | | | | | | |!| | | | | | |!| |!| | | | |!| }}
❑ Hospitalization <br>
{{familytree | | | |!| | | | | | | | | | | |!| | | | | | |!| | N01 | | N02 | N01= ''Administer [[anticoagulation]]'' <br>''(in case there are no contraindications)''<br>''during the diagnostic workup''|N02= ''Administer [[anticoagulation]]'' <br>''(in case there are no contraindications)''<br>''during the diagnostic workup''}}
❑ [[Trauma]] <br>
{{familytree | |,|-|^|-|-|-|.| | | | | | | |!| | | | | | |!| |!| | | | |!| | }}
❑ [[Pregnancy]] <br>
{{familytree | F01 | | | | F02 | | | | | | F03 | | | | | | F04 | | | | |!| F01= No| F02= Yes| F03= '''Order [[CT]]'''| F04= '''Order [[D-dimer]]'''}}
❑ [[Postpartum]] <br>
{{familytree | |!| | | | | |!| | | | | |,|-|^|-|.| | | |,|-|^|-|.| | | |!| }}
❑ [[Heart failure]] <br>
{{familytree | |!| | | | | |!| | | | | G02 | | G03 | | G04 | | G05 | | |!| G01= | G02= Positive| G03= Negative| G04= Positive| G05= Negative}}
❑ Immobility<br>
{{familytree | |!| | | |,|-|^|-|.| | | |!| | | |!| | | |!| | | |!| | | |!| }}
❑ Obesity<br>
{{familytree | |!| | | H01 | | H02 | | |!| | | |!| | | H03 | | H04 | | H05 | | | H01= Is the patient unstable <br> OR<br> no other tests are available?| H02=Is the patient stabilized <br> AND <br> CT is now available?| H03= '''Order CT'''| H04= PE is excluded| H05= '''Order [[CT]]'''}}
❑ [[Malignancy]]<br>
{{familytree | |!| | | |!| | | |!| | | |!| | | |!| | | |)|-|-|-|.| | | |)|-|-|-|.| | }}
❑ [[Stroke]] <br>
{{familytree | |!| | | |!| | | |!| | | |!| | | |!| | | L01 | | L02 | | L03 | | L04 | L01= Positive| L02= Negative| L03= Positive| L04= Negative}}
❑ [[Oral contraceptive]] or [[hormone replacement therapy]]
{{familytree | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | | |!| | }}
----
{{familytree | I01 | | I02 | | I03 | | I04 | | I05 | | I06 | | I07 | | I08 | | I09 | I01= PE is excluded| I02= Consider [[thrombolytic therapy]] or [[embolectomy]]| I03= Order CT| I04= PE is confirmed| I05=PE is excluded| I06= PE is confirmed| I07= PE is excluded| I08= PE is confirmed| I09= PE is excluded}}
'''Obtain a detailed history:''' <br>
{{familytree | | | | | | | |,|-|^|-|.| | | | }}
❑ Previous episode of VTE
{{familytree | | | | | | | J01 | | J02 | | | J01= Positive for PE| J02= Negative for PE}}
:❑ Age
{{familytree | | | | | | | |!| | | |!| | | | }}
:❑ Location
{{familytree | | | | | | | K01 | | K02 | | | K01= PE is confirmed| K02= PE is excluded}}
❑ Past medical history:
{{familytree/end}}
:❑ [[Collagen vascular disease]]
:❑ [[Myeloproliferative disease]]
:❑ [[Nephrotic syndrome]]
:❑ [[Atherosclerosis]]
❑ Abortion at second or third trimester of pregancy (suggestive of an inherited thrombophilia or APS)<br>
❑ Drugs that may induce APS
:❑ [[Hydralazine]]
:❑ [[Phenothiazine]]
:❑ [[Procainamide]]
</div>}}
{{familytree  | | | | | | | |!| | | }}
{{familytree  | | | | | | | C01 | | C01=<div style="float: left; text-align: left; width: 35em; padding:1em;">'''Examine the patient:''' <br>
 
'''Vital signs''' <br>
 
 
</div>}}
{{familytree | | | | | | | |!| | | }}
{{familytree  | | | | | | | D01 | | D01= <div style="float: left; text-align: left; width: 35em; padding:1em;">'''[[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Assess the pretest probability of DVT]]'''<br> ([[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Wells score shown below]])</div>}}
{{familytree  | | | | | | | |!| | | }}
{{familytree | | | | | | | E01 | | E01=
<div style="float: left; text-align: left; width: 35em; padding:1em;">'''Consider alternative diagnoses:''' <br>
❑ [[Muscle strain]] or [[muscle tear]] <br>
❑ [[Immobilization]] that led to leg swelling <br>
❑ [[Lymphedema]] <br>
❑ [[Lymphangitis]] <br>
❑ [[Venous valvular insufficiency]] <br>
❑ [[Baker's cyst]] <br>
❑ [[Cellulitis]] <br>
[[Superficial thrombophlebitis]]
</div>}}
{{familytree | | | | | | | |!| | | }}
{{familytree | | | | | | | F01 | | F01=
<div style="float: left; text-align: left; width: 35em; padding:1em;">'''Order tests:''' <br>
❑ [[CBC-D]] <br>
[[PT]] and [[aPTT]]
❑ [[Creatinine]] (to rule out nephrotic syndrome)
❑ [[Liver function test]] </div> }}
{{familytree | | | | | | | |!| | | }}
{{familytree  | | | | | | | K01 | | | | | | K01= Is the suspected DVT a first or a recurrent episode?}}
{{familytree | | | | | |,|-|^|-|.| | | | | }}
{{familytree  | | | | | L01 | | L02 | | |L01= First suspected episode| L02= Suspected recurrent episode}}
{{familytree  | | | | | |!| | | |!| | | | | }}
{{familytree  | | | | | M01 | | M02 | | | | M01= <div style="float: left; text-align: left; width: 35em; padding:1em;">'''[[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Assess the pretest probability of DVT]]'''<br> ([[Deep vein thrombosis resident survival guide#Assessment of the Pre-Test Probability of DVT|Wells score shown below]])| M02= ([[Deep vein thrombosis resident survival guide#Complete Diagnostic Approach for Suspected Recurrent Lower Extremity DVT|Click here for the diagnostic approach]])</div>}}
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | }}
{{familytree  | N01 | | N02 | | N03 | | | | N01= Low pretest probability<br>([[Deep vein thrombosis resident survival guide#Low Pretest Probability|Click here for the diagnostic approach]])| N02= Moderate pretest probability<br>([[Deep vein thrombosis resident survival guide#ModeratePretest Probability|Click here for the diagnostic approach]])| N03= High pretest probability<br>([[Deep vein thrombosis resident survival guide#High Pretest Probability|Click here for the diagnostic approach]])}}
{{Family tree/end}}
 
===Assessment of the Pre-Test Probability of DVT===
====Calculation of Wells Score for DVT====
{| style="cellpadding=0; cellspacing= 0; width: 600px;"
|-
| style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Variables'''||style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Score'''<ref name="pmid16403932">{{cite journal| author=Wells PS, Owen C, Doucette S, Fergusson D, Tran H| title=Does this patient have deep vein thrombosis? | journal=JAMA | year= 2006 | volume= 295 | issue= 2 | pages= 199-207 | pmid=16403932 | doi=10.1001/jama.295.2.199 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16403932  }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17213132 Review in: Evid Based Med. 2006 Aug;11(4):119]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16813372 Review in: ACP J Club. 2006 Jul-Aug;145(1):24] </ref>
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Active cancer with either palliative therapy or treatment that is either ongoing or within the prior 6 months|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Patient was recently bedridden for at least 3 days<br> OR Major surgery in the prior 12 weeks necessitating general or regional anesthesia|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Recent plaster immobilization, paresis or paralysis of the lower extremities|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Tenderness that is localized is the distribution of the deep veins|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Leg is entirely swollen|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Calf is swollen for 3 cm or move compared to the other calf|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Pitting edema in the symptomatic leg|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Presence of collateral superficial veins|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |Previous DVT|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |There is an alternative diagnosis as likely as DVT|| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |-2
|-
|}
 
====Interpretation of Wells Score for DVT====
{| style="cellpadding=0; cellspacing= 0; width: 600px;"
|-
| style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Score'''||style="padding: 0 5px; font-size: 100%; background: #F5F5F5;" align=center | '''Pretest probability'''<ref name="pmid16403932">{{cite journal| author=Wells PS, Owen C, Doucette S, Fergusson D, Tran H| title=Does this patient have deep vein thrombosis? | journal=JAMA | year= 2006 | volume= 295 | issue= 2 | pages= 199-207 | pmid=16403932 | doi=10.1001/jama.295.2.199 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16403932  }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17213132 Review in: Evid Based Med. 2006 Aug;11(4):119]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16813372 Review in: ACP J Club. 2006 Jul-Aug;145(1):24] </ref><ref name="pmid9428249">{{cite journal| author=Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L et al.| title=Value of assessment of pretest probability of deep-vein thrombosis in clinical management. | journal=Lancet | year= 1997 | volume= 350 | issue= 9094 | pages= 1795-8 | pmid=9428249 | doi=10.1016/S0140-6736(97)08140-3 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9428249  }} </ref>
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |≥3 ||style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | High
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |1 or 2 ||style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Moderate
|-
| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left |0 or less ||style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Low
|}
 
====Modified Well Score====
<ref name="pmid14507948">{{cite journal| author=Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J et al.| title=Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. | journal=N Engl J Med | year= 2003 | volume= 349 | issue= 13 | pages= 1227-35 | pmid=14507948 | doi=10.1056/NEJMoa023153 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14507948  }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15122830 Review in: ACP J Club. 2004 May-Jun;140(3):67] </ref>  Normal  0          false  false  false    EN-US  X-NONE  X-NONE

Revision as of 13:32, 22 May 2014

Complete Diagnostic Approach

A complete diagnostic approach should be carried out after a focused initial rapid evaluation is conducted and following initiation of any urgent intervention.[1]

 
 
 
 
 
 
Characterize the symptoms in the involved extremity:

❑ Swelling
❑ Pain
❑ Erythema

❑ Warmth
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Identify possible precipitating factors:
❑ Recent surgery
❑ Hospitalization
Trauma
Pregnancy
Postpartum
Heart failure
❑ Immobility
❑ Obesity
Malignancy
Stroke
Oral contraceptive or hormone replacement therapy


Obtain a detailed history:
❑ Previous episode of VTE

❑ Age
❑ Location

❑ Past medical history:

Collagen vascular disease
Myeloproliferative disease
Nephrotic syndrome
Atherosclerosis

❑ Abortion at second or third trimester of pregancy (suggestive of an inherited thrombophilia or APS)
❑ Drugs that may induce APS

Hydralazine
Phenothiazine
Procainamide
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Examine the patient:

Vital signs


 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Consider alternative diagnoses:

Muscle strain or muscle tear
Immobilization that led to leg swelling
Lymphedema
Lymphangitis
Venous valvular insufficiency
Baker's cyst
Cellulitis
Superficial thrombophlebitis

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Order tests:

CBC-D
PT and aPTTCreatinine (to rule out nephrotic syndrome)

Liver function test
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Is the suspected DVT a first or a recurrent episode?
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
First suspected episode
 
Suspected recurrent episode
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
(Click here for the diagnostic approach)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Low pretest probability
(Click here for the diagnostic approach)
 
Moderate pretest probability
(Click here for the diagnostic approach)
 
High pretest probability
(Click here for the diagnostic approach)
 
 
 

Assessment of the Pre-Test Probability of DVT

Calculation of Wells Score for DVT

Variables Score[2]
Active cancer with either palliative therapy or treatment that is either ongoing or within the prior 6 months 1
Patient was recently bedridden for at least 3 days
OR Major surgery in the prior 12 weeks necessitating general or regional anesthesia
1
Recent plaster immobilization, paresis or paralysis of the lower extremities 1
Tenderness that is localized is the distribution of the deep veins 1
Leg is entirely swollen 1
Calf is swollen for 3 cm or move compared to the other calf 1
Pitting edema in the symptomatic leg 1
Presence of collateral superficial veins 1
Previous DVT 1
There is an alternative diagnosis as likely as DVT -2

Interpretation of Wells Score for DVT

Score Pretest probability[2][3]
≥3 High
1 or 2 Moderate
0 or less Low

Modified Well Score

[4] Normal 0 false false false EN-US X-NONE X-NONE

  1. Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD; et al. (2012). "Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines". Chest. 141 (2 Suppl): e351S–418S. doi:10.1378/chest.11-2299. PMC 3278048. PMID 22315267.
  2. 2.0 2.1 Wells PS, Owen C, Doucette S, Fergusson D, Tran H (2006). "Does this patient have deep vein thrombosis?". JAMA. 295 (2): 199–207. doi:10.1001/jama.295.2.199. PMID 16403932. Review in: Evid Based Med. 2006 Aug;11(4):119 Review in: ACP J Club. 2006 Jul-Aug;145(1):24
  3. Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L; et al. (1997). "Value of assessment of pretest probability of deep-vein thrombosis in clinical management". Lancet. 350 (9094): 1795–8. doi:10.1016/S0140-6736(97)08140-3. PMID 9428249.
  4. Wells PS, Anderson DR, Rodger M, Forgie M, Kearon C, Dreyer J; et al. (2003). "Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis". N Engl J Med. 349 (13): 1227–35. doi:10.1056/NEJMoa023153. PMID 14507948. Review in: ACP J Club. 2004 May-Jun;140(3):67