DNA glycosylase: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
 
Line 3: Line 3:
{{SI}}
{{SI}}


{{EH}}
 


==Overview==
==Overview==
Line 26: Line 26:
[[ja:DNAグリコシラーゼ]]
[[ja:DNAグリコシラーゼ]]
{{WikiDoc Sources}}
{{WikiDoc Sources}}
{{SIB}}

Latest revision as of 00:27, 9 August 2012


WikiDoc Resources for DNA glycosylase

Articles

Most recent articles on DNA glycosylase

Most cited articles on DNA glycosylase

Review articles on DNA glycosylase

Articles on DNA glycosylase in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on DNA glycosylase

Images of DNA glycosylase

Photos of DNA glycosylase

Podcasts & MP3s on DNA glycosylase

Videos on DNA glycosylase

Evidence Based Medicine

Cochrane Collaboration on DNA glycosylase

Bandolier on DNA glycosylase

TRIP on DNA glycosylase

Clinical Trials

Ongoing Trials on DNA glycosylase at Clinical Trials.gov

Trial results on DNA glycosylase

Clinical Trials on DNA glycosylase at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on DNA glycosylase

NICE Guidance on DNA glycosylase

NHS PRODIGY Guidance

FDA on DNA glycosylase

CDC on DNA glycosylase

Books

Books on DNA glycosylase

News

DNA glycosylase in the news

Be alerted to news on DNA glycosylase

News trends on DNA glycosylase

Commentary

Blogs on DNA glycosylase

Definitions

Definitions of DNA glycosylase

Patient Resources / Community

Patient resources on DNA glycosylase

Discussion groups on DNA glycosylase

Patient Handouts on DNA glycosylase

Directions to Hospitals Treating DNA glycosylase

Risk calculators and risk factors for DNA glycosylase

Healthcare Provider Resources

Symptoms of DNA glycosylase

Causes & Risk Factors for DNA glycosylase

Diagnostic studies for DNA glycosylase

Treatment of DNA glycosylase

Continuing Medical Education (CME)

CME Programs on DNA glycosylase

International

DNA glycosylase en Espanol

DNA glycosylase en Francais

Business

DNA glycosylase in the Marketplace

Patents on DNA glycosylase

Experimental / Informatics

List of terms related to DNA glycosylase


Overview

DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.2. Base excision repair is the mechanism by which nucleotide residues in DNA with chemically altered nitrogen bases can be removed and replaced.

DNA glycosylase generates an apurinic or apyrimidinic site by removing the nitrogen base while leaving the sugar-phosphate backbone intact. These AP sites are recognised by AP endonuclease enzymes which complete the rest of the repair.

Some examples of DNA glycosylases:

  • Ogg1 (yeast) or hOgg1 (humans) which removes 8-oxo-guanine, a type of modified nucleotide typically found after DNA is exposed to oxidative mutagens. See also OGG1.
  • uracil-DNA glycosylase, found in prokaryotes and eukaryotes, which removes uracil from DNA.

References

  • Griffiths, Anthony J. et al (2005). Introduction to Genetic Analysis (8th Ed.). W.H. Freeman. ISBN 0-7167-4939-4

External links

Template:WikiDoc Sources