DGKZ

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
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RefSeq (mRNA)

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RefSeq (protein)

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Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[1][2]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[2]

Interactions

DGKZ has been shown to interact with P110α.[3]

References

  1. Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem. 271 (17): 10230–6. doi:10.1074/jbc.271.17.10230. PMID 8626588.
  2. 2.0 2.1 "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa".
  3. Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. United States. 278 (41): 39542–7. doi:10.1074/jbc.M307153200. ISSN 0021-9258. PMID 12890670.

Further reading