DCP1A: Difference between revisions

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{{Infobox_gene}}
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'''mRNA-decapping enzyme 1A''' is a [[protein]] that in humans is encoded by the ''DCP1A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55802| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = DCP1 decapping enzyme homolog A (S. cerevisiae)
| HGNCid = 18714
| Symbol = DCP1A
| AltSymbols =; HSA275986; Nbla00360; SMAD4IP1; SMIF
| OMIM = 607010
| ECnumber = 
| Homologene = 10178
| MGIid = 1923151
| GeneAtlas_image1 = PBB_GE_DCP1A_218508_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000184 |text = mRNA catabolic process, nonsense-mediated decay}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55802
    | Hs_Ensembl = ENSG00000162290
    | Hs_RefseqProtein = NP_060873
    | Hs_RefseqmRNA = NM_018403
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 53296430
    | Hs_GenLoc_end = 53356677
    | Hs_Uniprot = Q9NPI6
    | Mm_EntrezGene = 75901
    | Mm_Ensembl = ENSMUSG00000021962
    | Mm_RefseqmRNA = NM_133761
    | Mm_RefseqProtein = NP_598522
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 29308621
    | Mm_GenLoc_end = 29356072
    | Mm_Uniprot = Q3TAP6
  }}
}}
'''DCP1 decapping enzyme homolog A (S. cerevisiae)''', also known as '''DCP1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55802| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.<ref name="entrez">{{cite web | title = Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55802| accessdate = }}</ref>
| summary_text = Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.<ref name="entrez" />
}}
}}
==Interactions==
DCP1A has been shown to [[Protein-protein interaction|interact]] with [[DCP2]]<ref name=pmid12417715>{{cite journal |doi=10.1128/MCB.22.23.8114-8121.2002 |last=Lykke-Andersen |first=Jens |date=Dec 2002 |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay |journal=Mol. Cell. Biol. |volume=22 |issue=23 |pages=8114–21 |publisher= |location = United States| issn = 0270-7306| pmid = 12417715 | bibcode = | oclc =| id = | url = | language = | laysummary = | laysource = | laydate = | quote = |pmc=134073 }}</ref> and [[UPF1]].<ref name=pmid12417715/> It has also been shown to interact with [[GW128|GW182]], a [[P-body]] marker.<ref>{{Cite journal|last=EYSTATHIOY|first=THEOPHANY|last2=JAKYMIW|first2=ANDREW|last3=CHAN|first3=EDWARD K.L.|last4=SÉRAPHIN|first4=BERTRAND|last5=COUGOT|first5=NICOLAS|last6=FRITZLER|first6=MARVIN J.|date=2003-10-01|title=The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies|journal=RNA|volume=9|issue=10|pages=1171–1173|doi=10.1261/rna.5810203|issn=1355-8382|pmc=1370480|pmid=13130130}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bai RY, Koester C, Ouyang T, ''et al.'' |title=SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. |journal=Nat. Cell Biol. |volume=4 |issue= 3 |pages= 181-90 |year= 2002 |pmid= 11836524 |doi= 10.1038/ncb753 }}
*{{cite journal  | vauthors=Bai RY, Koester C, Ouyang T |title=SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. |journal=Nat. Cell Biol. |volume=4 |issue= 3 |pages= 181–90 |year= 2002 |pmid= 11836524 |doi= 10.1038/ncb753 |display-authors=etal}}
*{{cite journal  | author=Callebaut I |title=An EVH1/WH1 domain as a key actor in TGFbeta signalling. |journal=FEBS Lett. |volume=519 |issue= 1-3 |pages= 178-80 |year= 2002 |pmid= 12023040 |doi=  }}
*{{cite journal  | author=Callebaut I |title=An EVH1/WH1 domain as a key actor in TGFbeta signalling. |journal=FEBS Lett. |volume=519 |issue= 1-3 |pages= 178–80 |year= 2002 |pmid= 12023040 |doi=10.1016/S0014-5793(02)02751-5 }}
*{{cite journal  | author=Lykke-Andersen J |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8114-21 |year= 2003 |pmid= 12417715 |doi=  }}
*{{cite journal  | author=Lykke-Andersen J |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8114–21 |year= 2003 |pmid= 12417715 |doi= 10.1128/MCB.22.23.8114-8121.2002| pmc=134073 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489-501 |year= 2003 |pmid= 12515382 |doi=  }}
*{{cite journal  | vauthors=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi= 10.1017/S1355838202021726| pmc=1370355 }}
*{{cite journal  | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793-801 |year= 2003 |pmid= 12927788 |doi=  }}
*{{cite journal  | vauthors=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719-23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274 }}
*{{cite journal  | vauthors=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719–23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274 | pmc=1855297 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905-15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
*{{cite journal  | vauthors=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905–15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


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{{Post transcriptional modification}}
 
 
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Latest revision as of 07:17, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.[1]

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.[1]

Interactions

DCP1A has been shown to interact with DCP2[2] and UPF1.[2] It has also been shown to interact with GW182, a P-body marker.[3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)".
  2. ↑ 2.0 2.1 Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. United States. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
  3. ↑ EYSTATHIOY, THEOPHANY; JAKYMIW, ANDREW; CHAN, EDWARD K.L.; SÉRAPHIN, BERTRAND; COUGOT, NICOLAS; FRITZLER, MARVIN J. (2003-10-01). "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies". RNA. 9 (10): 1171–1173. doi:10.1261/rna.5810203. ISSN 1355-8382. PMC 1370480. PMID 13130130.

Further reading



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