Cyclosporiasis natural history, complications and prognosis: Difference between revisions

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==Complications==
==Complications==
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Biliary disease has also been reported after Cyclospora in- fections (50, 172). Acalculous cholecystitis was reported for HIV-positive and AIDS patients (172, 196) and resolved after initiation of treatment. These patients presented with right upper quadrant abdominal pain and elevated alkaline phos- phatase levels (171).
Biliary disease has also been reported after Cyclospora in- fections (50, 172). Acalculous cholecystitis was reported for HIV-positive and AIDS patients (172, 196) and resolved after initiation of treatment. These patients presented with right upper quadrant abdominal pain and elevated alkaline phos- phatase levels (171).


Coinfection with Cyclospora, Cryptosporidium, and other parasites has been described for immunocompetent and im- munocompromised individuals (9). Guillain-Barr ́e syndrome (GBS) (158) and Reiter syndrome (41) have also been re- ported following Cyclospora infection. In the first case, 18 h after admission the patient was quadriparetic, areflexic, and mechanically ventilated. Circumstantial evidence suggested a Cyclospora-induced immune response resulting in severe GBS (158). In the second case, the patient had cyclosporiasis and was sulfa allergic and thus could not be treated with tri- methoprim-sulfamethoxazole (TMP-SMX). Later, this patient developed ocular inflammation, inflammatory oligoarthritis, and sterile urethritis. Although Reiter syndrome could have been coincidental, the authors proposed Cyclospora as another infectious trigger for Reiter syndrome
Coinfection with Cyclospora, Cryptosporidium, and other parasites has been described for immunocompetent and im- munocompromised individuals (9). Guillain-Barr ́e syndrome (GBS) (158) and Reiter syndrome (41) have also been re- ported following Cyclospora infection. In the first case, 18 h after admission the patient was quadriparetic, areflexic, and mechanically ventilated. Circumstantial evidence suggested a Cyclospora-induced immune response resulting in severe GBS (158). In the second case, the patient had cyclosporiasis and was sulfa allergic and thus could not be treated with tri- methoprim-sulfamethoxazole (TMP-SMX). Later, this patient developed ocular inflammation, inflammatory oligoarthritis, and sterile urethritis. Although Reiter syndrome could have been coincidental, the authors proposed Cyclospora as another infectious trigger for Reiter syndrome
 
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==Prognosis==
==Prognosis==



Revision as of 20:25, 18 September 2014

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Overview

The symptoms usually start within one week of ingestion of contaminated food and water. If left untreated, symptoms may persist for weeks and months. This infection is not life threatening and is rarely associated with complications. People living in endemic area might have asymptomatic infections.

Natural History

Following inoculation of C. cayetanensis, the typical incubation period is about 7 days[1][2]

  • Symptoms of cyclosporiasis begin an average of 7 days (range, 2 days to > 2 weeks) after ingestion of sporulated oocysts (the infective form of the parasite).
  • If a person ill with cyclosporiasis is not treated, symptoms can persist for several weeks to a month or more. Some symptoms, such as diarrhea, can return, and some symptoms, such as muscle aches and fatigue, may continue after the gastrointestinal symptoms have gone away.
  • Infection is not usually life-threatening.
  • Reported complications from Cyclospora infection are rare, but have included malabsorption and cholecystitis.
  • Some people with Cyclospora infection experience no symptoms at all, particularly persons living in areas where the disease is endemic.


Complications

Prognosis

References

  1. Fleming CA, Caron D, Gunn JE, Barry MA (1998). "A foodborne outbreak of Cyclospora cayetanensis at a wedding: clinical features and risk factors for illness". Arch Intern Med. 158 (10): 1121–5. PMID 9605784.
  2. Herwaldt BL, Ackers ML (1997). "An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group". N Engl J Med. 336 (22): 1548–56. doi:10.1056/NEJM199705293362202. PMID 9164810.

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