Cutaneous T cell lymphoma: Difference between revisions

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==[[Cutaneous T cell lymphoma overview|Overview]]==


==Overview==
==[[Cutaneous T cell lymphoma classification|Classification]]==
'''Cutaneous T-Cell lymphoma''' (CTCL) is a class of [[non-Hodgkin's lymphoma]], which is a type of [[cancer]] of the [[immune system]].  Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of [[T cell]]s.  The [[malignant]] T cells in the body are pushed to the surface of the [[skin]] in a biological process used to rid the body of offending material, causing various [[lesion]]s to appear on the skin.  These lesions change shape as the disease progresses, typically beginning as what appears to be a [[rash]] and eventually forming plaques and [[tumor]]s before [[metastasis|metastatizing]] to other parts of the body.


==Types==
==[[Cutaneous T cell lymphoma historical perspective|Historical Perspective]]==
Though there are many types of CTCL and presentation can vary from individual to individual, there are two main forms:


* [[mycosis fungoides]] (MF)
==[[Cutaneous T cell lymphoma pathophysiology|Pathophysiology]]==
* [[Sézary syndrome]] (SS) 


There is some dispute over whether SS is an advanced form of MF or a different type of CTCL entirely - in either case, the prognosis for SS patients is substantially poorer than for those of MF.
==[[Cutaneous T cell lymphoma epidemiology and demographics|Epidemiology & Demographics]]==
 
==[[Cutaneous T cell lymphoma epidemiology and demographics|Risk Factors]]==
 
==[[Cutaneous T cell lymphoma screening|Screening]]==
 
==[[Cutaneous T cell lymphoma causes|Causes]]==
 
==[[Cutaneous T cell lymphoma differential diagnosis|Differentiating Cutaneous T cell lymphoma from other Diseases]]==
 
==[[Cutaneous T cell lymphoma natural history|Natural History, Complications & Prognosis]]==
 
==Diagnosis==
[[Cutaneous T cell lymphoma history and symptoms|History & Symptoms]] | [[Cutaneous T cell lymphoma physical examination|Physical Examination]] | [[Cutaneous T cell lymphoma staging|Staging]] | [[Cutaneous T cell lymphoma laboratory tests|Lab Tests]] | [[Cutaneous T cell lymphoma electrocardiogram|Electrocardiogram]] | [[Cutaneous T cell lymphoma chest x ray|Chest X Ray]] | [[Cutaneous T cell lymphoma CT|CT]] | [[Cutaneous T cell lymphoma MRI|MRI]] | [[Cutaneous T cell lymphoma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Cutaneous T cell lymphoma other imaging findings|Other Imaging Findings]] | [[Cutaneous T cell lymphoma other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.
[[Cutaneous T cell lymphoma medical therapy|Medical Therapy]] | [[Cutaneous T cell lymphoma surgery|Surgery]] | [[Cutaneous T cell lymphoma primary prevention|Primary Prevention]] | [[Cutaneous T cell lymphoma secondary prevention|Secondary Prevention]]
 
Treatments include: Topical Corticosteroids, Bexarotene Gel, Carmustine(Nitrogen Mustard), Mechlorethamine, Phototherapy (Broad & Narrow Band UVB or PUVA), Local & Total Skin Electron Beam Radiation, Conventional Radiation Therapy, Oral Corticosteroids, Bexarotene (Targretin®) Capsules, Photopheresis, Interferons, Denileukin Diftitox (Ontak®), Alemtuzumab (Campath-1H), Vorinostat (Zolinza®), Methotrexate, Pentostatin & other purine analogues (Fludarabine, 2- deoxychloroadenosine), Liposomal doxorubicin (Doxil®), Gemcitabine (Gemzar®), Cyclophosphamide, oral, Bone marrow/Stem cell, and Allogenic Transplantation.


==See also==
==Related chapters==
* [[Anaplastic large cell lymphoma]]
* [[Anaplastic large cell lymphoma]]


==External links==
==Resources==
* [http://www.lymphomainfo.net/nhl/types/ctcl-mf.html Cutaneous T-Cell Lymphomas - The lymphoma Information Network]
* [http://www.lymphomainfo.net/nhl/types/ctcl-mf.html Cutaneous T-Cell Lymphomas - The lymphoma Information Network]
* [http://www.clfoundation.org/ The Cutaneous Lymphoma Foundation]
* [http://www.clfoundation.org/ The Cutaneous Lymphoma Foundation]
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* [http://uuhsc.utah.edu/healthinfo/adult/skin/cuttcell.htm UUHSC]
* [http://uuhsc.utah.edu/healthinfo/adult/skin/cuttcell.htm UUHSC]
* [http://www.clinicaltrials.gov/ct/show/NCT00106431 NCI Clinical Trial using Depsipeptide to treat CTCL]
* [http://www.clinicaltrials.gov/ct/show/NCT00106431 NCI Clinical Trial using Depsipeptide to treat CTCL]
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Revision as of 16:52, 20 January 2012

Template:DiseaseDisorder infobox

Cutaneous T cell lymphoma Microchapters

Home

Patient Information

Overview

Classification

Mycosis fungoides
Sezary syndrome

Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

Historical Perspective

Pathophysiology

Epidemiology & Demographics

Risk Factors

Screening

Causes

Differentiating Cutaneous T cell lymphoma from other Diseases

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms | Physical Examination | Staging | Lab Tests | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention

Related chapters

Resources


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