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Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
Cullen's sign is blue-black bruising of the area around the umbilicus.
It is named for Thomas S. Cullen (1869-1953), who was an obstetrician and first described the sign in ruptured ectopic pregnancy in 1916.
This sign takes 24-48 hours to appear and predicts a severe attack of acute pancreatitis, with mortality rising from 8-10% to 40%.
It may be accompanied by Grey-Turner's sign (bruising of the flank).
- acute pancreatitis, where methaemalbumin formed from digested blood tracks around the abdomen from the inflamed pancreas
- bleeding from blunt abdominal trauma
- bleeding from ruptured ectopic pregnancy
Importance of the sign is on a decline since better diagnostic modalities are now available
- ↑ Template:WhoNamedIt
- ↑ T. S. Cullen. Embryology, anatomy, and diseases of the umbilicus together with diseases of the urachus. Philadelphia, Saunders, and London, 1916.
Template:Eponymous medical signs for digestive system and general abdominal signs