Complex regional pain syndrome pathophysiology

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Template:Compex regional pain syndrome Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

The pathophysiology of CRPS remains unclear. However, recent research has suggested that oxidative damage (e.g. by free radicals) associated with one of the precipitating factors described earlier may play a role.[1]

Susceptibility

CRPS can strike at any age, but is more common between the ages of 40 and 60. It affects both men and women, but is more frequently seen in women. The number of reported CRPS cases among adolescents and young adults is increasing.

Investigators estimate that two to five percent of those with peripheral nerve injury and 12 to 21 percent of those with hemiplegia (paralysis of one side of the body) will suffer from CRPS.

Research has demonstrated that the administration of Vitamin C after an injury may decrease one's susceptibility to developing CRPS.[1]

References

  1. 1.0 1.1 Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW (2007). "Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures? A Randomized, Controlled, Multicenter Dose-Response Study". J Bone Joint Surg Am. 89 (7): 1424–1431. PMID 17606778.

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