Cluster headache differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saumya Easaw, M.B.B.S.[2]

Differentiating Cluster Headache from other Diseases

Differential of cluster headache usually involves syndromes that manifest as unilateral headache, brief but frequent attacks. Such syndromes include the following:

  • Chronic paroxysmal hemicrania (CPH) is a condition similar to cluster headache, but CPH responds well to treatment with the anti-inflammatory drug indomethacin. With CPH, the attacks are much shorter, often lasting only seconds.[1]
  • Short-lasting unilateral neuralgiform headache attacks (SUNCT and SUNA)
  • Trigeminal neuralgia
  • Primary stabbing headache
  • Headache associated with an underlying intracranial lesion

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