'''Chymotrypsin C''', also known as '''caldecrin''' or '''elastase 4''' is an [[enzyme]] that in humans is encoded by the ''CTRC'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: chymotrypsin C (caldecrin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11330| accessdate = }}</ref><ref name="pmid8635596">{{cite journal |vauthors=Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T | title = Molecular cloning and expression of human caldecrin | journal = FEBS Lett. | volume = 386 | issue = 1 | pages = 26–8 |date=May 1996 | pmid = 8635596 | doi = 10.1016/0014-5793(96)00377-8| url = }}</ref>
'''Chymotrypsin C''', also known as '''caldecrin''' or '''elastase 4''', is an [[enzyme]] that in humans is encoded by the ''CTRC'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: chymotrypsin C (caldecrin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11330| accessdate = }}</ref><ref name="pmid8635596">{{cite journal |vauthors=Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T | title = Molecular cloning and expression of human caldecrin | journal = FEBS Lett. | volume = 386 | issue = 1 | pages = 26–8 |date=May 1996 | pmid = 8635596 | doi = 10.1016/0014-5793(96)00377-8| url = }}</ref>
Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRCgene.[1][2]
Function
Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity.[1]
↑Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T (May 1996). "Molecular cloning and expression of human caldecrin". FEBS Lett. 386 (1): 26–8. doi:10.1016/0014-5793(96)00377-8. PMID8635596.
Further reading
Freeman TC, Davies R, Calam J (1990). "Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors". Clin. Chim. Acta. 195 (1–2): 27–39. doi:10.1016/0009-8981(90)90191-T. PMID2093478.
Masson E, Chen JM, Scotet V, et al. (2008). "Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis". Hum. Genet. 123 (1): 83–91. doi:10.1007/s00439-007-0459-3. PMID18172691.
Kitahara K, Kawa S, Katsuyama Y, et al. (2008). "Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients". Dis. Markers. 25 (3): 175–80. doi:10.1155/2008/426764. PMID19096130.
Stavridi ES, O'Malley K, Lukacs CM, et al. (1996). "Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis". Biochemistry. 35 (33): 10608–15. doi:10.1021/bi9605806. PMID8718849.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID16710414.
Chang MC, Chang YT, Wei SC, et al. (2009). "Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan". Pancreatology. 9 (3): 287–92. doi:10.1159/000199437. PMID19407484.
Yoshino-Yasuda I, Kobayashi K, Akiyama M, et al. (1998). "Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene". J. Biochem. 123 (3): 546–54. doi:10.1093/oxfordjournals.jbchem.a021971. PMID9538241.
Harris WR, Malencik DA, Johnson CM, et al. (1990). "Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain". J. Biol. Chem. 265 (20): 11740–5. PMID2365696.
Derikx MH, Szmola R, te Morsche RH, et al. (2009). "Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants". Eur J Gastroenterol Hepatol. 21 (8): 889–94. doi:10.1097/MEG.0b013e32832183cf. PMID19404200.
