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==Overview==
==Overview==


'''Cholestyramine''' or '''colestyramine''' ('''PREVALITE''', '''CHOLESTYRAMINE,CHOLESTYRAMINE LIGHT''') is a [[bile acid sequestrant]], which binds [[bile]] in the [[gastrointestinal tract]] to prevent its reabsorption. It is a strong [[ion exchange resin]], which means that it can exchange its [[chloride]] [[anion]]s with anionic [[bile acid]]s in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a [[quaternary ammonium|quaternary]]  ammonium group attached to an inert [[styrene]]-[[divinylbenzene]] [[copolymer]].
Cholestyramine removes bile acids from the body by forming [[insoluble]] complexes with bile acids in the [[intestine]], which are then excreted in the [[feces]]. When bile acids are excreted, [[blood plasma|plasma]] [[cholesterol]] is converted to bile acid to normalize bile acid levels.  This conversion of cholesterol into bile acids lowers plasma cholesterol levels.




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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}]
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}]
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[[Category:Hepatology]]
[[Category:Bile acid sequestrants]]
[[Category:Cardiovasuclar Drugs]]
[[Category:Drugs]]
[[Category:Drugs]]

Revision as of 15:38, 10 February 2014


Cholestyramine
PREVALITE® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Cholestyramine
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

For patient information about Cholestyramine, click here.

Synonyms / Brand Names:

Overview

Cholestyramine or colestyramine (PREVALITE, CHOLESTYRAMINE,CHOLESTYRAMINE LIGHT) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means that it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer.

Cholestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, which are then excreted in the feces. When bile acids are excreted, plasma cholesterol is converted to bile acid to normalize bile acid levels. This conversion of cholesterol into bile acids lowers plasma cholesterol levels.


Category

FDA Package Insert

Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

External Links

Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information

Media Resources
Slides, Video, Images, MP3, Podcasts, etc.

Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español

Publication Resources

Most Recent Articles onCholestyramine

Review Articles on Cholestyramine

Articles on Cholestyramine in N Eng J Med, Lancet, BMJ

WikiDoc State of the Art Review

Textbook Information onCholestyramine

References

Template:Lipid modifying agents

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