Chlamydophila psittaci: Difference between revisions

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''Chlamydophila psittaci'' is a small bacterium (0.5 [[micrometre]]s) which undergoes several transformations during its life cycle. It exists as an [[elementary body]] (EB) in between [[Host (biology)|host]]s. The EB is not biologically active but is resistant to [[Natural environment|environment]]al stresses and can survive outside of a host. The EB travels from an [[infection|infected]] bird to the [[lung]]s of a non-infected bird or person in small [[droplet]]s and is responsible for infection. Once in the lungs, the EB is taken up by [[cell (biology)|cell]]s in a pouch called an [[endosome]] by a process called [[phagocytosis]]. However, the EB is not destroyed by fusion with [[lysosome]]s as is typical for phagocytosed material. Instead, it transforms into a [[reticulate body]] and begins to replicate within the endosome. The reticulate bodies must utilize some of the host's cellular machinery to complete its replication. The reticulate bodies then convert back to elementary bodies and are released back into the lung, often after causing the death of the host cell. The EBs are thereafter able to infect new cells, either in the same [[organism]] or in a new host. Thus, the life cycle of C. psittaci is divided between the elementary body which is able to infect new hosts but can not replicate and the reticulate body which replicates but is not able to cause new infection.
''Chlamydophila psittaci'' is a small bacterium (0.5 [[micrometre]]s) which undergoes several transformations during its life cycle. It exists as an [[elementary body]] (EB) in between [[Host (biology)|host]]s. The EB is not biologically active but is resistant to [[Natural environment|environment]]al stresses and can survive outside of a host. The EB travels from an [[infection|infected]] bird to the [[lung]]s of a non-infected bird or person in small [[droplet]]s and is responsible for infection. Once in the lungs, the EB is taken up by [[cell (biology)|cell]]s in a pouch called an [[endosome]] by a process called [[phagocytosis]]. However, the EB is not destroyed by fusion with [[lysosome]]s as is typical for phagocytosed material. Instead, it transforms into a [[reticulate body]] and begins to replicate within the endosome. The reticulate bodies must utilize some of the host's cellular machinery to complete its replication. The reticulate bodies then convert back to elementary bodies and are released back into the lung, often after causing the death of the host cell. The EBs are thereafter able to infect new cells, either in the same [[organism]] or in a new host. Thus, the life cycle of C. psittaci is divided between the elementary body which is able to infect new hosts but can not replicate and the reticulate body which replicates but is not able to cause new infection.
   
   
=== Treatment===
===Antimicrobial Regimen===
* Chlamydophila psittaci
:* 1. '''Respiratory psittacosis (Pneumonia)'''<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref>
 
::* 1.1 '''Adult'''
:* Pneumonia<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref>
:::* Preferred regimen (1): [[Doxycycline]] 100 mg PO bid for 10-21 days
 
:::* Preferred regimen (2): [[Tetracycline]] 500  mg PO qid for 10-21 days
::* Adult
:::* Alternative regimen: [[Minocycline]]
:::* Preferred regimen : [[Doxycycline]] 100 mg PO bid daily {{or}}  [[Tetracycline]] 500  mg PO qid for 10-21 days
::* 1.2 '''Pediatric'''
:::* Alternative regimen :[[Minocycline]]
:::* 1.2.1 '''Mild infection, Infants >3 months'''
 
::::* Preferred regimen: [[Azithromycin ]] 10 mg/kg PO qd on day 1 {{then}} 5 mg/kg PO q24h  for 4 days; (Maximum, 500 mg for 1st dose, 250 mg for subsequent doses)
::* Pediatric
:::* 1.2.2 '''Moderate-severe infection, Infants >3 months'''
:::* Preferred regimen: [[Azithromycin ]]
::::* Preferred regimen: [[Azithromycin ]] 10 mg/kg IV q24h for 2 days {{then}} 5 mg/kg PO qd for 3 days; (Maximum, 500 mg/dose IV; 250 mg/dose PO)
:::*Alternative regimen: fluoroquinolones
::* 1.3 '''Pregnant Patients'''
 
:::* Preferred regimen: [[Azithromycin ]] 500 mg PO on day 1 {{then}} by 250 mg qd on days 2-5  {{or}}  500 mg  IV as a single dose for at least 2 days, followed by 500 mg PO qd  for 7- 10 days
::* Pregnant Patients
:::* Preferred regimen : [[Azithromycin ]]250 mg to 500 mg PO daily × 7 days.
:::*Alternative  regimen: fluoroquinolones
 
::* Endocarditis in valve replacement patients
:::* Preferred regimen : [[Doxycycline]] 100 mg PO bid daily
:::* Alternative regimen : fluoroquinolones.


==Gallery==
==Gallery==

Revision as of 17:58, 28 July 2015


Chlamydophila psittaci
Direct fluorescent antibody stain of a mouse brain impression smear showing C. psittaci.
Direct fluorescent antibody stain of a mouse brain impression smear showing C. psittaci.
Scientific classification
Kingdom: Bacteria
Phylum: Chlamydiae
Order: Chlamydiales
Family: Chlamydiaceae
Genus: Chlamydophila
Species: C. psittaci

Chlamydophila psittaci is a lethal intracellular bacterial species that causes endemic avian chlamydiosis, epizootic outbreaks in mammals, and respiratory psittacosis in humans. Chlamydophila psittaci is transmitted by inhalation, contact or ingestion among birds and to mammals. Psittacosis in birds and in humans often starts with flu-like symptoms and becomes a life-threatening pneumonia. Many strains remain quiescent in birds until activated under stress. Birds are excellent, highly mobile vectors for the distribution of chlamydial infection because they feed on, and have access to, the detritus of infected animals of all sorts.

Chlamydophila psittaci was previously classified as Chlamydia psittaci. The former 'mammalian' Chlamydia psittaci abortion, feline and Guinea pig strains have been moved to three new species (see: Chlamydophila abortus, Chlamydophila felis, Chlamydophila caviae).

C. psittaci in birds is often systemic and infections can be inapparent, severe, acute or chronic with intermittent shedding. C. psittaci strains in birds infect mucosal epithelial cells and macrophages of the respiratory tract. Septicaemia eventually develops and the bacteria become localized in epithelial cells and macrophages of most organs, conjunctiva, and gastrointestinal tract. It can also be passed in the eggs. Stress will commonly trigger onset of severe symptoms, resulting in rapid deterioration and death. C. psittaci strains are similar in virulence, grow readily in cell culture, have 16S-rRNA genes that differ by <0.8%, and belong to eight known serovars. All should be considered to be readily transmissible to humans.

C. psittaci serovar A is endemic among psittacine birds and has caused sporadic zoonotic disease in humans, other mammals and tortoises. Serovar B is endemic among pigeons, has been isolated from turkeys, and has also been identified as the cause of abortion in a dairy herd. Serovars C and D are occupational hazards for slaughterhouse workers and for people in contact with birds. Serovar E isolates (known as Cal-10, MP or MN) have been obtained from a variety of avian hosts worldwide and, although they were associated with the 1920s–1930s outbreak in humans, a specific reservoir for serovar E has not been identified. The M56 and WC serovars were isolated during outbreaks in mammals. Many C. psittaci strains are susceptible to bacteriophages.

Life cycle and method of infection

File:Chlamydophila pneumoniae.jpg
Life cycle of Chlamydophila psittaci

Chlamydophila psittaci is a small bacterium (0.5 micrometres) which undergoes several transformations during its life cycle. It exists as an elementary body (EB) in between hosts. The EB is not biologically active but is resistant to environmental stresses and can survive outside of a host. The EB travels from an infected bird to the lungs of a non-infected bird or person in small droplets and is responsible for infection. Once in the lungs, the EB is taken up by cells in a pouch called an endosome by a process called phagocytosis. However, the EB is not destroyed by fusion with lysosomes as is typical for phagocytosed material. Instead, it transforms into a reticulate body and begins to replicate within the endosome. The reticulate bodies must utilize some of the host's cellular machinery to complete its replication. The reticulate bodies then convert back to elementary bodies and are released back into the lung, often after causing the death of the host cell. The EBs are thereafter able to infect new cells, either in the same organism or in a new host. Thus, the life cycle of C. psittaci is divided between the elementary body which is able to infect new hosts but can not replicate and the reticulate body which replicates but is not able to cause new infection.

Antimicrobial Regimen

  • 1. Respiratory psittacosis (Pneumonia)[1]
  • 1.1 Adult
  • 1.2 Pediatric
  • 1.2.1 Mild infection, Infants >3 months
  • Preferred regimen: Azithromycin 10 mg/kg PO qd on day 1 THEN 5 mg/kg PO q24h for 4 days; (Maximum, 500 mg for 1st dose, 250 mg for subsequent doses)
  • 1.2.2 Moderate-severe infection, Infants >3 months
  • Preferred regimen: Azithromycin 10 mg/kg IV q24h for 2 days THEN 5 mg/kg PO qd for 3 days; (Maximum, 500 mg/dose IV; 250 mg/dose PO)
  • 1.3 Pregnant Patients
  • Preferred regimen: Azithromycin 500 mg PO on day 1 THEN by 250 mg qd on days 2-5 OR 500 mg IV as a single dose for at least 2 days, followed by 500 mg PO qd for 7- 10 days

Gallery

References

  • chlamydiae.com [1]
  • Madigan, Martinko, and Parker. Brock Biology of Microorganisms. 10th ed. Upper Saddle River, NJ: Prentice Hall, 2003. ISBN 0-13-049147-0

de:Chlamydophila psittaci nl:Chlamydophila psittaci

Template:WikiDoc Sources

  1. Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Public Health Image Library (PHIL)".