Central pontine myelinolysis natural history, complications and prognosis

Central pontine myelinolysis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Natural History, Complications, and Prognosis

Natural History

• The symptoms of central pontine myelinolysis typically develop immediately after injury to the neurons of the brain stem.

Complications

• Patients, with Central Pontine Myelinolysis, may have permanent neurological damages.

• Common complications of central pontine myelinolysis include:
  • Locked-in syndrome
  • Quadriparesis
  • Walking difficulties
  • Pseudobulbar palsy
  • Parkinson's disease symptoms
  • Pneumonia

Prognosis

• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with central pontine myelinolysis is approximately [--]%.
• Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
• The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with central pontine myelinolysis.
• [Subtype of disease/malignancy] is associated with the most favorable prognosis.
• The prognosis varies with the [characteristic] of the tumor; [subtype of disease/malignancy] have the most favorable prognosis.