Central pontine myelinolysis natural history, complications and prognosis: Difference between revisions
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===Complications=== | ===Complications=== | ||
* Patients, with Central Pontine Myelinolysis, may | * Patients, with Central Pontine Myelinolysis, may develop permanent neurological damages. | ||
*Common complications of central pontine myelinolysis include: | *Common complications of central pontine myelinolysis include:<ref name="pmid25379502">{{cite journal| author=Sohn MK, Nam JH| title=Locked-in Syndrome due to Central Pontine Myelinolysis: Case Report. | journal=Ann Rehabil Med | year= 2014 | volume= 38 | issue= 5 | pages= 702-6 | pmid=25379502 | doi=10.5535/arm.2014.38.5.702 | pmc=4221401 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25379502 }} </ref><ref name="pmid28392953">{{cite journal| author=Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H| title=Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis. | journal=Case Rep Neurol Med | year= 2017 | volume= 2017 | issue= | pages= 1471096 | pmid=28392953 | doi=10.1155/2017/1471096 | pmc=5368399 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28392953 }} </ref><ref name="pmid4092709">{{cite journal| author=Pfister HW, Einhäupl KM, Brandt T| title=Mild central pontine myelinolysis: a frequently undetected syndrome. | journal=Eur Arch Psychiatry Neurol Sci | year= 1985 | volume= 235 | issue= 3 | pages= 134-9 | pmid=4092709 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4092709 }} </ref><ref name="pmid21607027">{{cite journal| author=Dolciotti C, Nuti A, Cipriani G, Borelli P, Baldacci F, Logi C et al.| title=Cerebellar ataxia with complete clinical recovery and resolution of MRI lesions related to central pontine myelinolysis: case report and literature review. | journal=Case Rep Neurol | year= 2010 | volume= 2 | issue= 3 | pages= 157-62 | pmid=21607027 | doi=10.1159/000323429 | pmc=3098816 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21607027 }} </ref><ref name="pmid9667573">{{cite journal| author=Seiser A, Schwarz S, Aichinger-Steiner MM, Funk G, Schnider P, Brainin M| title=Parkinsonism and dystonia in central pontine and extrapontine myelinolysis. | journal=J Neurol Neurosurg Psychiatry | year= 1998 | volume= 65 | issue= 1 | pages= 119-21 | pmid=9667573 | doi=10.1136/jnnp.65.1.119 | pmc=2170170 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9667573 }} </ref><ref name="pmid23608854">{{cite journal| author=Grech R, Galvin L, Brennan P, Thornton J| title=Central pontine myelinolysis. | journal=BMJ Case Rep | year= 2013 | volume= 2013 | issue= | pages= | pmid=23608854 | doi=10.1136/bcr-2013-008920 | pmc=3645781 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23608854 }} </ref> | ||
**[[Locked-In syndrome|Locked-in syndrome]] | **[[Locked-In syndrome|Locked-in syndrome]] | ||
**[[Quadriparesis]] | **[[Quadriparesis]] | ||
** | **[[Ataxia]] | ||
** | **Acute [[Psychosis]] | ||
**[[Pseudobulbar palsy|Pseudobulbar pals]]<nowiki/>[[Pseudobulbar palsy|y]] | **[[Pseudobulbar palsy|Pseudobulbar pals]]<nowiki/>[[Pseudobulbar palsy|y]] | ||
**[[Parkinson's disease]] symptoms | **[[Parkinson's disease]] symptoms | ||
**[[Dystonia]] | |||
**[[Pneumonia]] | **[[Pneumonia]] | ||
**[[Coma]] | **[[Coma]] |
Revision as of 15:23, 25 September 2019
Central pontine myelinolysis Microchapters |
Differentiating Central pontine myelinolysis from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Central pontine myelinolysis natural history, complications and prognosis On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of central pontine myelinolysis typically develop immediately after injury to the neurons of the brain stem.
Complications
- Patients, with Central Pontine Myelinolysis, may develop permanent neurological damages.
- Common complications of central pontine myelinolysis include:[1][2][3][4][5][6]
- Locked-in syndrome
- Quadriparesis
- Ataxia
- Acute Psychosis
- Pseudobulbar palsy
- Parkinson's disease symptoms
- Dystonia
- Pneumonia
- Coma
- Death
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with central pontine myelinolysis is approximately [--]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with central pontine myelinolysis.
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of the tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Sohn MK, Nam JH (2014). "Locked-in Syndrome due to Central Pontine Myelinolysis: Case Report". Ann Rehabil Med. 38 (5): 702–6. doi:10.5535/arm.2014.38.5.702. PMC 4221401. PMID 25379502.
- ↑ Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H (2017). "Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis". Case Rep Neurol Med. 2017: 1471096. doi:10.1155/2017/1471096. PMC 5368399. PMID 28392953.
- ↑ Pfister HW, Einhäupl KM, Brandt T (1985). "Mild central pontine myelinolysis: a frequently undetected syndrome". Eur Arch Psychiatry Neurol Sci. 235 (3): 134–9. PMID 4092709.
- ↑ Dolciotti C, Nuti A, Cipriani G, Borelli P, Baldacci F, Logi C; et al. (2010). "Cerebellar ataxia with complete clinical recovery and resolution of MRI lesions related to central pontine myelinolysis: case report and literature review". Case Rep Neurol. 2 (3): 157–62. doi:10.1159/000323429. PMC 3098816. PMID 21607027.
- ↑ Seiser A, Schwarz S, Aichinger-Steiner MM, Funk G, Schnider P, Brainin M (1998). "Parkinsonism and dystonia in central pontine and extrapontine myelinolysis". J Neurol Neurosurg Psychiatry. 65 (1): 119–21. doi:10.1136/jnnp.65.1.119. PMC 2170170. PMID 9667573.
- ↑ Grech R, Galvin L, Brennan P, Thornton J (2013). "Central pontine myelinolysis". BMJ Case Rep. 2013. doi:10.1136/bcr-2013-008920. PMC 3645781. PMID 23608854.