CHKB (gene)

Choline kinase beta
PDB rendering based on 2ig7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ig7​
Identifiers
Symbols	CHKB ; CHETK; CHKL
External IDs	Template:MGI HomoloGene: 88718
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Choline kinase beta, also known as CHKB, is a human gene.

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.

Further reading

• Aoyama C, Liao H, Ishidate K (2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog. Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.CS1 maint: Multiple names: authors list (link)
• Ishidate K (1997). "Choline/ethanolamine kinase from mammalian tissues". Biochim. Biophys. Acta. 1348 (1–2): 70–8. PMID 9370318.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirosawa M, Nagase T, Murahashi Y; et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. PMID 11258795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamazaki N, Shinohara Y, Kajimoto K; et al. (2000). "Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I.". J. Biol. Chem. 275 (41): 31739–46. doi:10.1074/jbc.M006322200. PMID 10918069.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aoyama C, Yamazaki N, Terada H, Ishidate K (2000). "Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta". J. Lipid Res. 41 (3): 452–64. PMID 10706593.CS1 maint: Multiple names: authors list (link)
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aoyama C, Nakashima K, Matsui M, Ishidate K (1998). "Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase". Biochim. Biophys. Acta. 1390 (1): 1–7. PMID 9487136.CS1 maint: Multiple names: authors list (link)
• Yamazaki N, Yamanaka Y, Hashimoto Y; et al. (1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I.". FEBS Lett. 409 (3): 401–6. PMID 9224698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)