CEACAM3: Difference between revisions

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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Carcinoembryonic antigen-related cell adhesion molecule 3''' ('''CEACAM3''') also known as '''CD66d''' ('''C'''luster of '''D'''ifferentiation '''66d'''), is a member of the [[carcinoembryonic antigen]] (CEA) [[gene]] family..<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1084| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Carcinoembryonic antigen-related cell adhesion molecule 3
| HGNCid = 1815
| Symbol = CEACAM3
| AltSymbols =; CEA; CD66D; CGM1; MGC119875; W264; W282
| OMIM = 609142
| ECnumber = 
| Homologene = 86055
| MGIid = 1347248
| GeneAtlas_image1 = PBB_GE_CEACAM3_208052_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEACAM3_210789_x_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1084
    | Hs_Ensembl = ENSG00000170956
    | Hs_RefseqProtein = NP_001806
    | Hs_RefseqmRNA = NM_001815
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 46992381
    | Hs_GenLoc_end = 47007431
    | Hs_Uniprot = P40198
    | Mm_EntrezGene = 26366
    | Mm_Ensembl = ENSMUSG00000054169
    | Mm_RefseqmRNA = NM_007675
    | Mm_RefseqProtein = NP_031701
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 24486036
    | Mm_GenLoc_end = 24489997
    | Mm_Uniprot = Q61400
  }}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 3''' ('''CEACAM3''') also known as '''CD66d''' ('''C'''luster of '''D'''ifferentiation '''66d'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1084| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1084| accessdate = }}</ref>
| summary_text = This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez" />
}}
}}
==Use==
CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.<ref>CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.</ref>


==See also==
==See also==
Line 59: Line 16:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Khan WN, Frängsmyr L, Teglund S, ''et al.'' |title=Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. |journal=Genomics |volume=14 |issue= 2 |pages= 384-90 |year= 1992 |pmid= 1427854 |doi=  }}
*{{cite journal  | vauthors=Khan WN, Frängsmyr L, Teglund S |title=Identification of three new genes and estimation of the size of the carcinoembryonic antigen family |journal=Genomics |volume=14 |issue= 2 |pages= 384–90 |year= 1992 |pmid= 1427854 |doi=10.1016/S0888-7543(05)80230-7 |display-authors=etal}}
*{{cite journal  | author=Kuroki M, Arakawa F, Matsuo Y, ''et al.'' |title=Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. |journal=J. Biol. Chem. |volume=266 |issue= 18 |pages= 11810-7 |year= 1991 |pmid= 2050678 |doi=  }}
*{{cite journal  | vauthors=Kuroki M, Arakawa F, Matsuo Y |title=Molecular cloning of nonspecific cross-reacting antigens in human granulocytes |journal=J. Biol. Chem. |volume=266 |issue= 18 |pages= 11810–7 |year= 1991 |pmid= 2050678 |doi=  |display-authors=etal}}
*{{cite journal  | author=Thompson JA, Mauch EM, Chen FS, ''et al.'' |title=Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons. |journal=Biochem. Biophys. Res. Commun. |volume=158 |issue= 3 |pages= 996-1004 |year= 1989 |pmid= 2537643 |doi=  }}
*{{cite journal  | vauthors=Thompson JA, Mauch EM, Chen FS |title=Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons |journal=Biochem. Biophys. Res. Commun. |volume=158 |issue= 3 |pages= 996–1004 |year= 1989 |pmid= 2537643 |doi=10.1016/0006-291X(89)92821-0 |display-authors=etal}}
*{{cite journal  | author=Watt SM, Fawcett J, Murdoch SJ, ''et al.'' |title=CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant. |journal=Blood |volume=84 |issue= 1 |pages= 200-10 |year= 1994 |pmid= 8018919 |doi=  }}
*{{cite journal  | vauthors=Watt SM, Fawcett J, Murdoch SJ |title=CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant |journal=Blood |volume=84 |issue= 1 |pages= 200–10 |year= 1994 |pmid= 8018919 |doi=  |display-authors=etal}}
*{{cite journal  | author=Nagel G, Grunert F, Kuijpers TW, ''et al.'' |title=Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family. |journal=Eur. J. Biochem. |volume=214 |issue= 1 |pages= 27-35 |year= 1993 |pmid= 8508798 |doi=  }}
*{{cite journal  | vauthors=Nagel G, Grunert F, Kuijpers TW |title=Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family |journal=Eur. J. Biochem. |volume=214 |issue= 1 |pages= 27–35 |year= 1993 |pmid= 8508798 |doi=10.1111/j.1432-1033.1993.tb17892.x |display-authors=etal}}
*{{cite journal  | author=Skubitz KM, Campbell KD, Skubitz AP |title=CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. |journal=J. Leukoc. Biol. |volume=60 |issue= 1 |pages= 106-17 |year= 1996 |pmid= 8699114 |doi=  }}
*{{cite journal  | vauthors=Skubitz KM, Campbell KD, Skubitz AP |title=CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils |journal=J. Leukoc. Biol. |volume=60 |issue= 1 |pages= 106–17 |year= 1996 |pmid= 8699114 |doi=  }}
*{{cite journal  | author=Streichert T, Ebrahimnejad A, Ganzer S, ''et al.'' |title=The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 191-7 |year= 2001 |pmid= 11708798 |doi= 10.1006/bbrc.2001.5955 }}
*{{cite journal  | vauthors=Streichert T, Ebrahimnejad A, Ganzer S |title=The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 191–7 |year= 2001 |pmid= 11708798 |doi= 10.1006/bbrc.2001.5955 |display-authors=etal}}
*{{cite journal  | author=Skubitz KM, Campbell KD, Skubitz AP |title=Synthetic peptides from the N-domains of CEACAMs activate neutrophils. |journal=J. Pept. Res. |volume=58 |issue= 6 |pages= 515-26 |year= 2002 |pmid= 12005421 |doi=  }}
*{{cite journal  | vauthors=Skubitz KM, Campbell KD, Skubitz AP |title=Synthetic peptides from the N-domains of CEACAMs activate neutrophils |journal=J. Pept. Res. |volume=58 |issue= 6 |pages= 515–26 |year= 2002 |pmid= 12005421 |doi=10.1034/j.1399-3011.2001.00931.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Booth JW, Telio D, Liao EH, ''et al.'' |title=Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14037-45 |year= 2003 |pmid= 12571236 |doi= 10.1074/jbc.M211879200 }}
*{{cite journal  | vauthors=Booth JW, Telio D, Liao EH |title=Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14037–45 |year= 2003 |pmid= 12571236 |doi= 10.1074/jbc.M211879200 |display-authors=etal}}
*{{cite journal  | author=McCaw SE, Schneider J, Liao EH, ''et al.'' |title=Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. |journal=Mol. Microbiol. |volume=49 |issue= 3 |pages= 623-37 |year= 2003 |pmid= 12864848 |doi=  }}
*{{cite journal  | vauthors=McCaw SE, Schneider J, Liao EH |title=Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor |journal=Mol. Microbiol. |volume=49 |issue= 3 |pages= 623–37 |year= 2003 |pmid= 12864848 |doi=10.1046/j.1365-2958.2003.03591.x |display-authors=etal}}
*{{cite journal  | author=Schmitter T, Agerer F, Peterson L, ''et al.'' |title=Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. |journal=J. Exp. Med. |volume=199 |issue= 1 |pages= 35-46 |year= 2004 |pmid= 14707113 |doi= 10.1084/jem.20030204 }}
*{{cite journal  | vauthors=Schmitter T, Agerer F, Peterson L |title=Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens |journal=J. Exp. Med. |volume=199 |issue= 1 |pages= 35–46 |year= 2004 |pmid= 14707113 |doi= 10.1084/jem.20030204 | pmc=1887732 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Gimbergues P, Dauplat MM, Cayre A, ''et al.'' |title=Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category. |journal=Eur J Surg Oncol |volume=33 |issue= 1 |pages= 16-22 |year= 2007 |pmid= 17071045 |doi= 10.1016/j.ejso.2006.09.013 }}
*{{cite journal  | vauthors=Gimbergues P, Dauplat MM, Cayre A |title=Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category |journal=Eur J Surg Oncol |volume=33 |issue= 1 |pages= 16–22 |year= 2007 |pmid= 17071045 |doi= 10.1016/j.ejso.2006.09.013 |display-authors=etal}}
*{{cite journal  | author=Gasser M, Gerstlauer C, Grimm M, ''et al.'' |title=Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer. |journal=Ann. Surg. Oncol. |volume=14 |issue= 4 |pages= 1272-84 |year= 2007 |pmid= 17211733 |doi= 10.1245/s10434-006-9155-0 }}
*{{cite journal  | vauthors=Gasser M, Gerstlauer C, Grimm M |title=Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer |journal=Ann. Surg. Oncol. |volume=14 |issue= 4 |pages= 1272–84 |year= 2007 |pmid= 17211733 |doi= 10.1245/s10434-006-9155-0 |display-authors=etal}}
*{{cite journal  | author=Howell NR, Zheng W, Cheng L, ''et al.'' |title=Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis? |journal=Int. J. Gynecol. Pathol. |volume=26 |issue= 2 |pages= 134-40 |year= 2007 |pmid= 17413979 |doi= 10.1097/01.pgp.0000233166.56385.d0 }}
*{{cite journal  | vauthors=Howell NR, Zheng W, Cheng L |title=Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis? |journal=Int. J. Gynecol. Pathol. |volume=26 |issue= 2 |pages= 134–40 |year= 2007 |pmid= 17413979 |doi= 10.1097/01.pgp.0000233166.56385.d0 |display-authors=etal}}
*{{cite journal  | author=Stern-Ginossar N, Nedvetzki S, Markel G, ''et al.'' |title=Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4424-34 |year= 2007 |pmid= 17878338 |doi=  }}
*{{cite journal  | vauthors=Stern-Ginossar N, Nedvetzki S, Markel G |title=Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4424–34 |year= 2007 |pmid= 17878338 |doi=  10.4049/jimmunol.179.7.4424|display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
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==External links==
==External links==
* {{MeshName|CEACAM3+protein,+human}}
* {{MeshName|CEACAM3+protein,+human}}
* {{UCSC gene info|CEACAM3}}


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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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{{membrane-protein-stub}}

Latest revision as of 20:58, 5 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..[1]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

Use

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.[2]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3".
  2. ↑ CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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