View source for CDC Classification System for HIV Infection in Adults and Adolescents

{{AIDS}}
{{CMG}}
==Overview==
This classification system is how the [[United States]] agency, the Centers for Disease Control and Prevention ([[Centers for Disease Control and Prevention|CDC]]) classifies HIV disease and infection. This is to allow the government to handle epidemic statistics and define who receives US government assistance. In 1993, the CDC added pulmonary [[tuberculosis]], recurrent [[pneumonia]], and invasive [[cervical cancer]] to the list of clinical conditions in the [[AIDS]] surveillance case definition published in 1987 and expanded the AIDS surveillance case definition to include all HIV-infected persons with CD4+ T-lymphocyte counts of less than 200 cells/uL or a CD4+ percentage of less than 14. Considerable variation exists in the relative risk of death following different AIDS defining clinical conditions.

==CDC Classification System for HIV Infection in Adults and Adolescents==
According to the US CDC definition, one has [[AIDS]] if he/she is infected with HIV and present with one of the following:

A CD4+ T-cell count below 200 cells/µl (or a CD4+ T-cell percentage of total lymphocytes of less than 14%).

'''or''' he/she has one of the following defining illnesses:

*[[Candidiasis]] of bronchi, trachea, or lungs 
*[[Candidiasis]] esophageal 
*[[Cervical cancer]] (invasive) 
*[[Coccidioidomycosis]], disseminated or extrapulmonary 
*[[Cryptococcosis]], extrapulmonary 
*[[Cryptosporidiosis]], chronic intestinal for longer than 1 month
*[[Cytomegalovirus]] disease (other than [[liver]], [[spleen]] or [[lymph nodes]])
*[[Encephalopathy]] (HIV-related) 
*[[Herpes simplex]]: chronic ulcer(s) (for more than 1 month); or [[bronchitis]], [[pneumonitis]], or [[esophagitis]] 
*[[Histoplasmosis]], disseminated or extrapulmonary
*[[Isosporiasis]], chronic intestinal (for more than 1 month) 
*[[Kaposi's sarcoma]]
*[[Lymphoma]] [[Burkitt's]], immunoblastic or primary brain 
*Mycobacterium avium complex 
*Mycobacterium, other species, disseminated or extrapulmonary 
*[[Pneumocystis jiroveci pneumonia|Pneumocystis carinii pneumonia]] 
*[[Pneumonia]] (recurrent) 
*[[Progressive multifocal leukoencephalopathy]]
*[[Salmonella]] septicemia (recurrent) 
*[[Toxoplasmosis]] of the brain 
*[[Tuberculosis]] 
*Wasting syndrome due to HIV

People who are not infected with [[HIV]] may also develop these conditions; this does not mean they have [[AIDS]]. However, when an individual presents laboratory evidence against HIV infection, a diagnosis of AIDS is ruled out unless the patient has not:

* undergone high-dose corticoid therapy or other immunosuppressive/cytotoxic therapy in the three months before the onset of the indicator disease 
* '''OR''' been diagnosed with [[Hodgkin's disease]], non-Hodgkin's lymphoma, lymphocytic leukemia, multiple myeloma, or any cancer of lymphoreticular or histiocytic tissue, or angioimmunoblastic lymphoadenopathy 
* '''OR''' a genetic immunodeficiency syndrome atypical of HIV infection, such as one involving hypogamma globulinemia

'''AND'''

* the individual has had ''Pneumocystis carinii'' pneumonia 
* '''OR''' one of the above defining illnesses '''AND''' a CD4+ T-cell count below 200 cells/µl (or a CD4+ T-cell percentage of total lymphocytes of less than 14%).

==References==

*CDC. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987;36:1-15S. 
*CDC. [http://www.cdc.gov/mmwr/preview/mmwrhtml/00018871.htm 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults]
*[http://aidsinfo.nih.gov/other/cbrochure/english/01_en.html AIDS info]
*[http://www.aidsonline.com/pt/re/aids/abstract.00002030-199809000-00006.htm Disease progression and survival following specific AIDS-defining conditions: a retrospective cohort study of 2048 HIV-infected persons in London.]
*[http://www.aids.gov AIDS.gov - The U.S. Federal Domestic HIV/AIDS Resource]
*[http://www.HIVtest.org HIVtest.org - Find an HIV testing site near you]

[[Category:HIV/AIDS]]
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