Revision as of 17:37, 9 October 2018 by imported>JCW-CleanerBot (→‎Further reading: clean up, replaced: journal = Aids → journal = AIDS)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
PubMed searchn/an/a
View/Edit Human

Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4[1][2] (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

See also


  1. Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS (September 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". The Journal of Biological Chemistry. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666.
  2. Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L (March 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature. 410 (6828): 608–11. doi:10.1038/35069118. PMID 11279502.

External links

Further reading

  • Weitzmann MN, Pacifici R (April 2006). "Estrogen regulation of immune cell bone interactions". Annals of the New York Academy of Sciences. 1068: 256–74. doi:10.1196/annals.1346.030. PMID 16831927.
  • Knolle PA, Gerken G (April 2000). "Local control of the immune response in the liver". Immunological Reviews. 174: 21–34. doi:10.1034/j.1600-0528.2002.017408.x. PMID 10807504.
  • Henz BM, Maurer M, Lippert U, Worm M, Babina M (February 2001). "Mast cells as initiators of immunity and host defense". Experimental Dermatology. 10 (1): 1–10. doi:10.1034/j.1600-0625.2001.100101.x. PMID 11168574.
  • Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Current Directions in Autoimmunity. Current Directions in Autoimmunity. 5: 113–30. doi:10.1159/000060550. ISBN 3-8055-7308-1. PMID 11826754.
  • Stove V, Verhasselt B (January 2006). "Modelling thymic HIV-1 Nef effects". Current HIV Research. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
  • Quaranta MG, Mattioli B, Giordani L, Viora M (November 2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB Journal. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
  • Freeman GJ, Disteche CM, Gribben JG, Adler DA, Freedman AS, Dougery J, Nadler LM (January 1992). "The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21". Blood. 79 (2): 489–94. PMID 1370389.
  • Selvakumar A, Mohanraj BK, Eddy RL, Shows TB, White PC, Dupont B (1992). "Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7". Immunogenetics. 36 (3): 175–81. doi:10.1007/BF00661094. PMID 1377173.
  • Freeman GJ, Gray GS, Gimmi CD, Lombard DB, Zhou LJ, White M, Fingeroth JD, Gribben JG, Nadler LM (September 1991). "Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7". The Journal of Experimental Medicine. 174 (3): 625–31. doi:10.1084/jem.174.3.625. PMC 2118924. PMID 1714935.
  • Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM (October 1989). "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells". Journal of Immunology. 143 (8): 2714–22. PMID 2794510.
  • Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (December 1995). "The cysteine-rich protein family of highly related LIM domain proteins". The Journal of Biological Chemistry. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
  • Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M (January 1995). "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL". Journal of Immunology. 154 (1): 97–105. PMID 7527824.
  • Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S (July 1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". Journal of Immunology. 155 (2): 917–24. PMID 7541827.
  • Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS (September 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". The Journal of Biological Chemistry. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666.
  • Tuosto L, Piazza C, Moretti S, Modesti A, Greenlaw R, Lechler R, Lombardi G, Piccolella E (October 1995). "Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis". European Journal of Immunology. 25 (10): 2917–22. doi:10.1002/eji.1830251031. PMID 7589092.
  • Chirmule N, Oyaizu N, Saxinger C, Pahwa S (June 1994). "Nef protein of HIV-1 has B-cell stimulatory activity". AIDS. 8 (6): 733–4. doi:10.1097/00002030-199406000-00002. PMID 8086129.
  • Weiskirchen R, Bister K (September 1993). "Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains". Oncogene. 8 (9): 2317–24. PMID 8361751.
  • Dono M, Zupo S, Augliera A, Burgio VL, Massara R, Melagrana A, Costa M, Grossi CE, Chiorazzi N, Ferrarini M (September 1996). "Subepithelial B cells in the human palatine tonsil. II. Functional characterization". European Journal of Immunology. 26 (9): 2043–9. doi:10.1002/eji.1830260912. PMID 8814244.
  • Reeves RH, Patch D, Sharpe AH, Borriello F, Freeman GJ, Edelhoff S, Disteche C (August 1997). "The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3". Mammalian Genome. 8 (8): 581–2. doi:10.1007/s003359900508. PMID 9250865.
  • Olivares EG, Montes MJ, Oliver C, Galindo JA, Ruiz C (September 1997). "Cultured human decidual stromal cells express B7-1 (CD80) and B7-2 (CD86) and stimulate allogeneic T cells". Biology of Reproduction. 57 (3): 609–15. doi:10.1095/biolreprod57.3.609. PMID 9282998.
  • Weiskirchen R, Erdel M, Utermann G, Bister K (August 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.