CD7

CD7 molecule
Identifiers
Symbols	CD7 ; GP40; LEU-9; TP41; Tp40
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4471
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CD7 (Cluster of Differentiation 7) is a human protein encoded by the CD7 gene.

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

See also

• Cluster of differentiation

Further reading

• Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation". Immunol. Res. 24 (1): 31–52. PMID 11485208.
• Baker E, Sandrin MS, Garson OM; et al. (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization". Immunogenetics. 31 (5–6): 412–3. PMID 1695199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schanberg LE, Fleenor DE, Kurtzberg J; et al. (1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 603–7. PMID 1703303.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshikawa K, Seto M, Ueda R; et al. (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7". Immunogenetics. 33 (5–6): 352–60. PMID 1711009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ware RE, Scearce RM, Dietz MA; et al. (1990). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule". J. Immunol. 143 (11): 3632–40. PMID 2479685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Osada S, Utsumi KR, Ueda R; et al. (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17". Cytogenet. Cell Genet. 47 (1–2): 8–10. PMID 3258561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aruffo A, Seed B (1988). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system". EMBO J. 6 (11): 3313–6. PMID 3501369.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Lee DM, Schanberg LE, Fleenor DE; et al. (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters". Immunogenetics. 44 (2): 108–14. PMID 8662072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bevec T, Stoka V, Pungercic G; et al. (1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.". J. Exp. Med. 183 (4): 1331–8. PMID 8666891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leta E, Hou Z, Lederman L, Jung LK (1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7". Cell. Immunol. 173 (1): 15–21. doi:10.1006/cimm.1996.0247. PMID 8871597.CS1 maint: Multiple names: authors list (link)
• Lee DM, Patel DD, Pendergast AM, Haynes BF (1997). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. 8 (8): 1195–203. PMID 8918688.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms". Genomics. 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID 9480746.CS1 maint: Multiple names: authors list (link)
• Steegmaier M, Yang B, Yoo JS; et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. PMID 9852078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1". J. Immunol. 163 (7): 3801–11. PMID 10490978.CS1 maint: Multiple names: authors list (link)
• Lyman SD, Escobar S, Rousseau AM; et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein". J. Biol. Chem. 275 (5): 3431–7. PMID 10652336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.CS1 maint: Multiple names: authors list (link)
• Rossi MI, Yokota T, Medina KL; et al. (2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes". Blood. 101 (2): 576–84. doi:10.1182/blood-2002-03-0896. PMID 12393702.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CD7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)