CD151: Difference between revisions

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{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''CD151 molecule''' ('''Raph blood group'''), also known as '''CD151''' ('''C'''luster of '''D'''ifferentiation '''151'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD151 CD151 molecule (Raph blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = CD151 molecule (Raph blood group)
| HGNCid = 1630
| Symbol = CD151
  | AltSymbols =; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24
| OMIM = 602243
| ECnumber = 
| Homologene = 20916
| MGIid = 1096360
| GeneAtlas_image1 = PBB_GE_CD151_204306_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 977
    | Hs_Ensembl = ENSG00000177697
    | Hs_RefseqProtein = NP_001034579
    | Hs_RefseqmRNA = NM_001039490
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 822961
    | Hs_GenLoc_end = 828830
    | Hs_Uniprot = P48509
    | Mm_EntrezGene = 12476
    | Mm_Ensembl = ENSMUSG00000025510
    | Mm_RefseqmRNA = NM_009842
    | Mm_RefseqProtein = NP_033972
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 141320142
    | Mm_GenLoc_end = 141322788
    | Mm_Uniprot = Q921J7
  }}
}}
{{SI}}
{{CMG}}


== Function ==


The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.<ref name="entrez" />


'''CD151 molecule (Raph blood group)''', also known as '''CD151'''  ('''C'''luster of '''D'''ifferentiation '''151'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD151 CD151 molecule (Raph blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977| accessdate = }}</ref>
== Interactions ==
[[File:Fibrosarcoma cells CD151.jpg|thumb|left|Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).]]
CD151 has been shown to [[Protein-protein interaction|interact]] with [[CD46]].<ref name=pmid10741407>{{cite journal | vauthors = Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E | title = CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans | journal = Eur. J. Immunol. | volume = 30 | issue = 3 | pages = 900–7 | date = March 2000 | pmid = 10741407 | doi = 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X }}</ref>


{{PBB_Summary
== See also ==
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CD151 CD151 molecule (Raph blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977| accessdate = }}</ref>
}}
==See also==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]
* [[Tetraspanin]]
* [[Tetraspanin]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Berditchevski F | title = Complexes of tetraspanins with integrins: more than meets the eye | journal = J. Cell Sci. | volume = 114 | issue = Pt 23 | pages = 4143–51 | year = 2002 | pmid = 11739647 | doi =  }}
| citations =
* {{cite journal | vauthors = Ashman LK | title = CD151 | journal = J. Biol. Regul. Homeost. Agents | volume = 16 | issue = 3 | pages = 223–6 | year = 2003 | pmid = 12456024 | doi =  }}
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi=  }}
* {{cite journal | vauthors = Ashman LK, Aylett GW, Mehrabani PA, Bendall LJ, Niutta S, Cambareri AC, Cole SR, Berndt MC | title = The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen | journal = Br. J. Haematol. | volume = 79 | issue = 2 | pages = 263–70 | year = 1992 | pmid = 1958484 | doi = 10.1111/j.1365-2141.1991.tb04531.x }}
*{{cite journal | author=Ashman LK |title=CD151. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 223-6 |year= 2003 |pmid= 12456024 |doi=  }}
* {{cite journal | vauthors = Fitter S, Tetaz TJ, Berndt MC, Ashman LK | title = Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3 | journal = Blood | volume = 86 | issue = 4 | pages = 1348–55 | year = 1995 | pmid = 7632941 | doi =  }}
*{{cite journal | author=Ashman LK, Aylett GW, Mehrabani PA, ''et al.'' |title=The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen. |journal=Br. J. Haematol. |volume=79 |issue= 2 |pages= 263-70 |year= 1992 |pmid= 1958484 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Fitter S, Tetaz TJ, Berndt MC, Ashman LK |title=Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. |journal=Blood |volume=86 |issue= 4 |pages= 1348-55 |year= 1995 |pmid= 7632941 |doi=  }}
* {{cite journal | vauthors = Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S | title = SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily | journal = J. Virol. | volume = 70 | issue = 5 | pages = 3258–63 | year = 1996 | pmid = 8627808 | pmc = 190191 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Hasegawa H, Kishimoto K, Yanagisawa K, Terasaki H, Shimadzu M, Fujita S | title = Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization | journal = Genomics | volume = 40 | issue = 1 | pages = 193–6 | year = 1997 | pmid = 9070943 | doi = 10.1006/geno.1996.4563 }}
*{{cite journal | author=Hasegawa H, Utsunomiya Y, Kishimoto K, ''et al.'' |title=SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily. |journal=J. Virol. |volume=70 |issue= 5 |pages= 3258-63 |year= 1996 |pmid= 8627808 |doi=  }}
* {{cite journal | vauthors = Sincock PM, Mayrhofer G, Ashman LK | title = Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin | journal = J. Histochem. Cytochem. | volume = 45 | issue = 4 | pages = 515–25 | year = 1997 | pmid = 9111230 | doi = 10.1177/002215549704500404 }}
*{{cite journal | author=Hasegawa H, Kishimoto K, Yanagisawa K, ''et al.'' |title=Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization. |journal=Genomics |volume=40 |issue= 1 |pages= 193-6 |year= 1997 |pmid= 9070943 |doi= 10.1006/geno.1996.4563 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Sincock PM, Mayrhofer G, Ashman LK |title=Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin. |journal=J. Histochem. Cytochem. |volume=45 |issue= 4 |pages= 515-25 |year= 1997 |pmid= 9111230 |doi= }}
* {{cite journal | vauthors = Fitter S, Seldin MF, Ashman LK | title = Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms | journal = Biochim. Biophys. Acta | volume = 1398 | issue = 1 | pages = 75–85 | year = 1998 | pmid = 9602068 | doi = 10.1016/S0167-4781(98)00034-7 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK | title = PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function | journal = J. Cell Sci. | volume = 112 ( Pt 6) | issue =  | pages = 833–44 | year = 1999 | pmid = 10036233 | doi =  }}
*{{cite journal | author=Fitter S, Seldin MF, Ashman LK |title=Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms. |journal=Biochim. Biophys. Acta |volume=1398 |issue= 1 |pages= 75-85 |year= 1998 |pmid= 9602068 |doi= }}
* {{cite journal | vauthors = Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E | title = Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions | journal = Biochem. J. | volume = 340 | issue = 1 | pages = 103–11 | year = 1999 | pmid = 10229664 | pmc = 1220227 | doi = 10.1042/0264-6021:3400103 }}
*{{cite journal | author=Sincock PM, Fitter S, Parton RG, ''et al.'' |title=PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. |journal=J. Cell. Sci. |volume=112 ( Pt 6) |issue=  |pages= 833-44 |year= 1999 |pmid= 10036233 |doi=  }}
* {{cite journal | vauthors = Testa JE, Brooks PC, Lin JM, Quigley JP | title = Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis | journal = Cancer Res. | volume = 59 | issue = 15 | pages = 3812–20 | year = 1999 | pmid = 10447000 | doi =  }}
*{{cite journal | author=Serru V, Le Naour F, Billard M, ''et al.'' |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. |journal=Biochem. J. |volume=340 ( Pt 1) |issue= |pages= 103-11 |year= 1999 |pmid= 10229664 |doi= }}
* {{cite journal | vauthors = Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A | title = The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes | journal = J. Cell Biol. | volume = 149 | issue = 4 | pages = 969–82 | year = 2000 | pmid = 10811835 | pmc = 2174566 | doi = 10.1083/jcb.149.4.969 }}
*{{cite journal | author=Testa JE, Brooks PC, Lin JM, Quigley JP |title=Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. |journal=Cancer Res. |volume=59 |issue= 15 |pages= 3812-20 |year= 1999 |pmid= 10447000 |doi=  }}
* {{cite journal | vauthors = Whittock NV, McLean WH | title = Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 2 | pages = 425–30 | year = 2001 | pmid = 11181065 | doi = 10.1006/bbrc.2001.4384 }}
*{{cite journal | author=Sterk LM, Geuijen CA, Oomen LC, ''et al.'' |title=The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. |journal=J. Cell Biol. |volume=149 |issue= 4 |pages= 969-82 |year= 2000 |pmid= 10811835 |doi= }}
* {{cite journal | vauthors = Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E | title = The major CD9 and CD81 molecular partner. Identification and characterization of the complexes | journal = J. Biol. Chem. | volume = 276 | issue = 17 | pages = 14329–37 | year = 2001 | pmid = 11278880 | doi = 10.1074/jbc.M011297200 }}
*{{cite journal | author=Whittock NV, McLean WH |title=Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 2 |pages= 425-30 |year= 2001 |pmid= 11181065 |doi= 10.1006/bbrc.2001.4384 }}
* {{cite journal | vauthors = Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S | title = Identification and characterization of the potential promoter regions of 1031 kinds of human genes | journal = Genome Res. | volume = 11 | issue = 5 | pages = 677–84 | year = 2001 | pmid = 11337467 | pmc = 311086 | doi = 10.1101/gr.gr-1640r}}
*{{cite journal | author=Charrin S, Le Naour F, Oualid M, ''et al.'' |title=The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14329-37 |year= 2001 |pmid= 11278880 |doi= 10.1074/jbc.M011297200 }}
* {{cite journal | vauthors = Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S | title = CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase | journal = Int. J. Cancer | volume = 97 | issue = 3 | pages = 336–43 | year = 2002 | pmid = 11774285 | doi = 10.1002/ijc.1605 }}
*{{cite journal | author=Suzuki Y, Tsunoda T, Sese J, ''et al.'' |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677-84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 }}
* {{cite journal | vauthors = Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME | title = Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis | journal = Mol. Biol. Cell | volume = 13 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11809818 | pmc = 65068 | doi = 10.1091/mbc.01-10-0481 }}
*{{cite journal | author=Kohno M, Hasegawa H, Miyake M, ''et al.'' |title=CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. |journal=Int. J. Cancer |volume=97 |issue= 3 |pages= 336-43 |year= 2002 |pmid= 11774285 |doi= }}
*{{cite journal | author=Zhang XA, Kazarov AR, Yang X, ''et al.'' |title=Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis. |journal=Mol. Biol. Cell |volume=13 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11809818 |doi= 10.1091/mbc.01-10-0481 }}
}}
{{refend}}
{{refend}}
== External links ==
* [https://www.ncbi.nlm.nih.gov/projects/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=raph Raph blood group system] in the [[BGMUT]] blood group antigen gene mutation database
* {{UCSC gene info|CD151}}


{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Membrane proteins}}


{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]


{{WikiDoc Sources}}
 
{{WH}}
{{membrane-protein-stub}}
[[Category:Blood antigen systems]]

Latest revision as of 16:27, 16 February 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[1]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[1]

Interactions

File:Fibrosarcoma cells CD151.jpg
Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.[2]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CD151 CD151 molecule (Raph blood group)".
  2. ↑ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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