CABIN1

Calcineurin binding protein 1
PDB rendering based on 1n6j.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1n6j​
Identifiers
Symbols	CABIN1 ; CAIN; KIAA0330
External IDs	Template:OMIM5 Template:MGI HomoloGene: 49307
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcineurin binding protein 1, also known as CABIN1, is a human gene.

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.

Further reading

• Liu JO (2004). "Endogenous protein inhibitors of calcineurin". Biochem. Biophys. Res. Commun. 311 (4): 1103–9. PMID 14623296.
• Laherty CD, Yang WM, Sun JM; et al. (1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–56. PMID 9150134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun L, Youn HD, Loh C; et al. (1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. PMID 9655484.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Youn HD, Sun L, Prywes R, Liu JO (1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. PMID 10531067.CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Youn HD, Grozinger CM, Liu JO (2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". J. Biol. Chem. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.CS1 maint: Multiple names: authors list (link)
• Lai MM, Luo HR, Burnett PE; et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Youn HD, Liu JO (2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. PMID 10933397.
• Esau C, Boes M, Youn HD; et al. (2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". J. Exp. Med. 194 (10): 1449–59. PMID 11714752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Han A, Pan F, Stroud JC; et al. (2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. doi:10.1038/nature01555. PMID 12700764.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y (2004). "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis". Cell. 116 (1): 51–61. PMID 14718166.CS1 maint: Multiple names: authors list (link)
• Rodríguez A, Martínez-Martínez S, López-Maderuelo MD; et al. (2005). "The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT". J. Biol. Chem. 280 (11): 9980–4. doi:10.1074/jbc.C400401200. PMID 15671033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li XN, Li YL, Liu GB, Ding YQ (2007). "Selection of choriocarcinoma-associated genes using bioinformatics". Di Yi Jun Yi Da Xue Xue Bao. 25 (1): 1–6. PMID 15683985.CS1 maint: Multiple names: authors list (link)
• Pan F, Means AR, Liu JO (2005). "Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation". EMBO J. 24 (12): 2104–13. doi:10.1038/sj.emboj.7600685. PMID 15902271.CS1 maint: Multiple names: authors list (link)
• Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.CS1 maint: Multiple names: authors list (link)