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{{Infobox_gene}}
{{PBB_Controls
'''Calcineurin-binding protein cabin-1''' is a [[protein]] that in humans is encoded by the ''CABIN1'' [[gene]].<ref name="pmid9655484">{{cite journal | vauthors = Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO | title = Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes | journal = Immunity | volume = 8 | issue = 6 | pages = 703–11 | date = Jun 1998 | pmid = 9655484 | pmc =  | doi = 10.1016/S1074-7613(00)80575-0 }}</ref><ref name="pmid9205841">{{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 4 | issue = 2 | pages = 141–50 | date = Apr 1997 | pmid = 9205841 | pmc = | doi = 10.1093/dnares/4.2.141 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CABIN1 calcineurin binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23523| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CABIN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n6j.
| PDB = {{PDB2|1n6j}}
| Name = Calcineurin binding protein 1
| HGNCid = 
| Symbol = CABIN1
| AltSymbols =; CAIN; KIAA0330
| OMIM = 604251
| ECnumber = 
| Homologene = 49307
| MGIid = 1298375
| GeneAtlas_image1 = PBB_GE_CABIN1_37652_at_tn.png
| GeneAtlas_image2 = PBB_GE_CABIN1_202624_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23523
    | Hs_Ensembl = ENSG00000099991
    | Hs_RefseqProtein = NP_036427
    | Hs_RefseqmRNA = NM_012295
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 22737765
    | Hs_GenLoc_end = 22904596
    | Hs_Uniprot = Q9Y6J0
    | Mm_EntrezGene = 104248
    | Mm_Ensembl = ENSMUSG00000020196
    | Mm_RefseqmRNA = NM_172549
    | Mm_RefseqProtein = NP_766137
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 75089828
    | Mm_GenLoc_end = 75208073
    | Mm_Uniprot = 
  }}
}}
'''Calcineurin binding protein 1''', also known as '''CABIN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CABIN1 calcineurin binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23523| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CABIN1 calcineurin binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23523| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CABIN1 has been shown to [[Protein-protein interaction|interact]] with:
* [[Amphiphysin]],<ref name = pmid10931822>{{cite journal | vauthors = Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH | title = The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 44 | pages = 34017–20 | date = Nov 2000 | pmid = 10931822 | doi = 10.1074/jbc.C000429200 }}</ref>
* [[MEF2B]],<ref name = pmid12700764>{{cite journal | vauthors = Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L | title = Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 | journal = Nature | volume = 422 | issue = 6933 | pages = 730–4 | date = Apr 2003 | pmid = 12700764 | doi = 10.1038/nature01555 }}</ref><ref name = pmid10531067>{{cite journal | vauthors = Youn HD, Sun L, Prywes R, Liu JO | title = Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 | journal = Science | volume = 286 | issue = 5440 | pages = 790–3 | date = Oct 1999 | pmid = 10531067 | doi =  10.1126/science.286.5440.790}}</ref>
* [[MEF2D]],<ref name = pmid10531067/><ref name = pmid10933397>{{cite journal | vauthors = Youn HD, Liu JO | title = Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 | journal = Immunity | volume = 13 | issue = 1 | pages = 85–94 | date = Jul 2000 | pmid = 10933397 | doi =  10.1016/s1074-7613(00)00010-8}}</ref>  and
* [[SIN3A]].<ref name = pmid10933397/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Liu JO | title = Endogenous protein inhibitors of calcineurin | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 4 | pages = 1103–9 | date = Nov 2003 | pmid = 14623296 | doi = 10.1016/j.bbrc.2003.10.020 }}
| citations =
* {{cite journal | vauthors = Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN | title = Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression | journal = Cell | volume = 89 | issue = 3 | pages = 349–56 | date = May 1997 | pmid = 9150134 | doi = 10.1016/S0092-8674(00)80215-9 }}
*{{cite journal | author=Liu JO |title=Endogenous protein inhibitors of calcineurin. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 4 |pages= 1103-9 |year= 2004 |pmid= 14623296 |doi= }}
* {{cite journal | vauthors = Youn HD, Sun L, Prywes R, Liu JO | title = Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 | journal = Science | volume = 286 | issue = 5440 | pages = 790–3 | date = Oct 1999 | pmid = 10531067 | doi = 10.1126/science.286.5440.790 }}
*{{cite journal | author=Laherty CD, Yang WM, Sun JM, ''et al.'' |title=Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. |journal=Cell |volume=89 |issue= 3 |pages= 349-56 |year= 1997 |pmid= 9150134 |doi= }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
* {{cite journal | vauthors = Youn HD, Grozinger CM, Liu JO | title = Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 29 | pages = 22563–7 | date = Jul 2000 | pmid = 10825153 | doi = 10.1074/jbc.C000304200 }}
*{{cite journal  | author=Sun L, Youn HD, Loh C, ''et al.'' |title=Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. |journal=Immunity |volume=8 |issue= 6 |pages= 703-11 |year= 1998 |pmid= 9655484 |doi=  }}
* {{cite journal | vauthors = Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH | title = The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 44 | pages = 34017–20 | date = Nov 2000 | pmid = 10931822 | doi = 10.1074/jbc.C000429200 }}
*{{cite journal | author=Youn HD, Sun L, Prywes R, Liu JO |title=Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. |journal=Science |volume=286 |issue= 5440 |pages= 790-3 |year= 1999 |pmid= 10531067 |doi= }}
* {{cite journal | vauthors = Youn HD, Liu JO | title = Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 | journal = Immunity | volume = 13 | issue = 1 | pages = 85–94 | date = Jul 2000 | pmid = 10933397 | doi = 10.1016/S1074-7613(00)00010-8 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J | title = Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells | journal = The Journal of Experimental Medicine | volume = 194 | issue = 10 | pages = 1449–59 | date = Nov 2001 | pmid = 11714752 | pmc = 2193671 | doi = 10.1084/jem.194.10.1449 }}
*{{cite journal | author=Youn HD, Grozinger CM, Liu JO |title=Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22563-7 |year= 2000 |pmid= 10825153 |doi= 10.1074/jbc.C000304200 }}
* {{cite journal | vauthors = Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L | title = Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 | journal = Nature | volume = 422 | issue = 6933 | pages = 730–4 | date = Apr 2003 | pmid = 12700764 | doi = 10.1038/nature01555 }}
*{{cite journal | author=Lai MM, Luo HR, Burnett PE, ''et al.'' |title=The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34017-20 |year= 2000 |pmid= 10931822 |doi= 10.1074/jbc.C000429200 }}
* {{cite journal | vauthors = Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y | title = Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis | journal = Cell | volume = 116 | issue = 1 | pages = 51–61 | date = Jan 2004 | pmid = 14718166 | doi = 10.1016/S0092-8674(03)01064-X }}
*{{cite journal | author=Youn HD, Liu JO |title=Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. |journal=Immunity |volume=13 |issue= 1 |pages= 85-94 |year= 2000 |pmid= 10933397 |doi= }}
* {{cite journal | vauthors = Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, Ortega-Pérez I, Redondo JM | title = The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT | journal = The Journal of Biological Chemistry | volume = 280 | issue = 11 | pages = 9980–4 | date = Mar 2005 | pmid = 15671033 | doi = 10.1074/jbc.C400401200 }}
*{{cite journal | author=Esau C, Boes M, Youn HD, ''et al.'' |title=Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. |journal=J. Exp. Med. |volume=194 |issue= 10 |pages= 1449-59 |year= 2001 |pmid= 11714752 |doi= }}
* {{cite journal | vauthors = Li XN, Li YL, Liu GB, Ding YQ | title = Selection of choriocarcinoma-associated genes using bioinformatics | journal = Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA | volume = 25 | issue = 1 | pages = 1–6 | date = Jan 2005 | pmid = 15683985 | doi =  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Pan F, Means AR, Liu JO | title = Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation | journal = The EMBO Journal | volume = 24 | issue = 12 | pages = 2104–13 | date = Jun 2005 | pmid = 15902271 | pmc = 1150881 | doi = 10.1038/sj.emboj.7600685 }}
*{{cite journal | author=Han A, Pan F, Stroud JC, ''et al.'' |title=Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. |journal=Nature |volume=422 |issue= 6933 |pages= 730-4 |year= 2003 |pmid= 12700764 |doi= 10.1038/nature01555 }}
* {{cite journal | vauthors = Jang H, Cho EJ, Youn HD | title = A new calcineurin inhibition domain in Cabin1 | journal = Biochemical and Biophysical Research Communications | volume = 359 | issue = 1 | pages = 129–35 | date = Jul 2007 | pmid = 17531200 | doi = 10.1016/j.bbrc.2007.05.066 }}
*{{cite journal | author=Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y |title=Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. |journal=Cell |volume=116 |issue= 1 |pages= 51-61 |year= 2004 |pmid= 14718166 |doi= }}
*{{cite journal | author=Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, ''et al.'' |title=The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 9980-4 |year= 2005 |pmid= 15671033 |doi= 10.1074/jbc.C400401200 }}
*{{cite journal | author=Li XN, Li YL, Liu GB, Ding YQ |title=Selection of choriocarcinoma-associated genes using bioinformatics. |journal=Di Yi Jun Yi Da Xue Xue Bao |volume=25 |issue= 1 |pages= 1-6 |year= 2007 |pmid= 15683985 |doi=  }}
*{{cite journal | author=Pan F, Means AR, Liu JO |title=Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. |journal=EMBO J. |volume=24 |issue= 12 |pages= 2104-13 |year= 2005 |pmid= 15902271 |doi= 10.1038/sj.emboj.7600685 }}
*{{cite journal | author=Jang H, Cho EJ, Youn HD |title=A new calcineurin inhibition domain in Cabin1. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 1 |pages= 129-35 |year= 2007 |pmid= 17531200 |doi= 10.1016/j.bbrc.2007.05.066 }}
}}
{{refend}}
{{refend}}
==External links==
* {{UCSC gene info|CABIN1}}
* {{UCSC gene info|KB-318B8.7}}
{{PDB Gallery|geneid=23523}}


{{gene-22-stub}}
{{gene-22-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:07, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.[1][2][3]

Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.[3]

Interactions

CABIN1 has been shown to interact with:

References

  1. Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO (Jun 1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.
  2. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  3. 3.0 3.1 "Entrez Gene: CABIN1 calcineurin binding protein 1".
  4. Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
  5. Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. doi:10.1038/nature01555. PMID 12700764.
  6. 6.0 6.1 Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
  7. 7.0 7.1 Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.

Further reading

External links