C8 complex

File:3OJY.png

High Resolution Crystal Structure of Human Complement Component 8

complement component 8, alpha polypeptide
Identifiers
Symbol	C8A
Entrez	731
HUGO	1352
OMIM	120950
RefSeq	NM_000562
UniProt	P07357
Other data
Locus	Chr. 1 p36.2-22.1

complement component 8, beta polypeptide
Identifiers
Symbol	C8B
Entrez	732
HUGO	1353
OMIM	1209660
RefSeq	NM_000066
UniProt	P073o58
Other data
Locus	Chr. 1 p36.2-22.1

complement component 8, gamma polypeptide
Identifiers
Symbol	C8G
Entrez	733
HUGO	1354
OMIM	120930
RefSeq	NM_000606
UniProt	P07360
Other data
Locus	Chr. 9 q34.3

Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).

A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

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Membrane attack complex. Some labels are in Polish.

Structure

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.

References

1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol

External links

• Complement+C8 at the US National Library of Medicine Medical Subject Headings (MeSH)

The crystal structure is now in the PDB, PDB ID 3OJY.