Brodie abscess overview: Difference between revisions
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[[Subacute]] [[Osteomyelitis]] | |||
==Overview== | ==Overview== | ||
Brodie abscess is a rare [[subacute]] or [[acute]] [[chronic]] [[osteomyelitis]] with a pus-filled [[cavity]], vascularized [[wall]] and hard [[sclerotic]] surrounding [[bone]]. It mostly involves the [[metaphysis]] of bones (especially [[tibia]]) but it can occur at any location and in a patients of any [[age]]. It classically presents with [[pain]] with out any other [[systemic]] [[symptoms]]. Thus making an [[accurate]] and timely [[diagnosis]] is usually difficult. It is usually mistaken with bone [[tumor]]. It has [[insidious onset]] and the [[inflammatory]] markers are [[unremarkable]]. Brodie abscess may be the result of inadequate [[treatment]] for [[acute]] [[osteomyelitis]] or may occur in the setting of a more strong host [[resistance]] to [[infection]], inoculation with less [[virulent]] [[organisms]], prior [[antibiotic]] exposure or a combination of these factors. Brodie's abscesses are mostly seen in children and [[adolescents]] with an average age of 19.5 years. The most commonly identified organism is [[staphylococcus aureus]]. Other [[pathogens]] such as [[Pseudomonas aeruginosa]], [[Klebsiella]] spp., and [[Salmonella typhi]] have been reported. In about 25% of cases, no organism is identified. The patient may present with [[chronic pain]] in the affected area in the absence of [[trauma]]. Laboratory findings are mostly includes normal [[WBC with differential]]. [[Inflammatory]] markers such [[Erythrocyte sedimentation rate]] and [[C-reactive protein]] levels are may be normal or elevated in about half of the cases. Definitive diagnosis is made with [[radiological]] [[imaging]]. The mainstay of treatment is [[surgical debridement]]t combined with [[antibiotics]]. | |||
==Historical Perspectives== | ==Historical Perspectives== | ||
[[Brodie abscess]] is first described by a British surgeon, sir [[Benjamin Brodie]], in 1832. | |||
Wiles reported Brodie abscesses as a specific form of [[osteomyelitis]] in 1951. Harris and Kirkaldy-Willis (1965) were the first to describe [[primary]] [[subacute]] [[osteomyelitis]] and present a [[radiograph]] [[diagnosing]] the condition. | |||
==Classification== | ==Classification== | ||
Brodie abscess was first classified [[radiologically]] by [[Kirkaldy-Willis]] from East-Africa. The currently utilized classification system was initially proposed by Gledhill in 1973 and then modified by Roberts et al in 1982. | |||
Type IA: [[Metaphyseal]] [[radiolucency]] without surrounding [[sclerosis]]. It may cause confusion with [[Eosinophilic granuloma]]. | |||
Type IB: [[Metaphyseal]] [[radiolucency]] with surrounding [[reactive bone]]. | |||
Type II: [[Metaphyseal]] [[radiolucency]] with [[cortical erosion]]. It resembles [[Osteosarcoma]]. | |||
Type III: [[Cortical]] [[diaphyseal]] [[radiolucency]] with [[periosteal]] reaction. It looks like [[Osteoid]] [[Osteoma]]. | |||
Type IV: [[Diaphyseal]] [[lesion]] with [[sub periosteal]] [[new bone]] formation. This type may have the appearance of “onion-skinning” and thus be confused with [[Ewing’s sarcoma]]. | |||
Type V: [[Epiphyseal]] [[radiolucency]] that may appear similar to a [[chondroblastoma]]. IT has similar appearance with [[Chondroblastoma]]. | |||
Type VI: [[Vertebral]] [[lesion]] that may mimic [[eosinophilic]] [[granuloma]] or [[tuberculous]] [[spondylitis]]. | |||
==Pathophysiology== | ==Pathophysiology== | ||
Local [[trauma]] and [[bacteremia]] lead to increased susceptibility to bacterial seeding of the [[metaphysis]]. history of trauma is reported in 30% of patients. Brodie abscess arises where the [[bacteria]] and the host defenses are equally balanced. | |||
==Causes== | ==Causes== | ||
[[Staphylococcus aureus]] is the most common [[pathogens]] identified, however it is only isolated in as few as 75% of cases. | |||
==Differentiating Brodie Abscess From Other Diseases== | ==Differentiating Brodie Abscess From Other Diseases== | ||
Other diseases such as [[osteoid osteoma]], [[Langerhans cell histiocytosis]], [[chondrosarcoma]], [[eosinophilic granuloma]] or [[tuberculosis]] may have similar presentation with brodie abscess and need further [[investigations]]. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Brodie's abscesses is generally observed in patients younger than 25 years of age, mostly seen in children and [[adolescents]] with an average age of 19.5 years. | |||
==Risk Factors== | ==Risk Factors== | ||
The development of brodie`s abscess could be the result of many factors such as inadequate treatment of [[acute osteomyelitis]] or [[antibiotic resistance]]. | |||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
== | Brodie`s abscess is a rare [[subacute osteomyelitis]]. It is usually located within the [[metaphysis]] of long [[bones]] although [[diaphyseal]] involvement is more common in adult. [[Tibia]] is the most commonly involved bone. If left untreated,, it may cause long term [[disability]], [[fracture]] or [[amputation]]. Prognosis is excellent after effective treatment. | ||
==Diagnosis== | |||
===History and Symptoms=== | ===History and Symptoms=== | ||
Brodie's abscesses are mostly seen in children and adolescents. It has gradual onset and can be difficult to diagnose. It presents mainly with [[bone]] [[pain]]. | |||
===Physical Examinations=== | ===Physical Examinations=== | ||
The main presenting physical signs are [[limping]], [[swelling]] and [[erythema]]. | |||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
Laboratory findings such as [[white blood cell count]] and differential usually shows normal. [[Erythrocyte sedimentation rate]] and [[C-reactive protein]] levels may be normal or could be elevated. | |||
===X-ray=== | ===X-ray=== | ||
The diagnosis is made mainly with [[radiological]] [[imaging]]. | |||
===CT Scan=== | ===CT Scan=== | ||
=== | CT-Scan reveals the same features as [[x-ray]] but additionally It enhances [[sinus]] [[tract]] and [[fistula]] to a [[joint]] or [[soft tissue]]. | ||
===MRI=== | |||
Definitive diagnosis is made using [[MRI]]. | |||
===Other Imaging Findings=== | ===Other Imaging Findings=== | ||
SPECT-CT is also used to diagnose [[brodie`s abscess]]. | |||
===Other Diagnostic Studies=== | ===Other Diagnostic Studies=== | ||
[[Blood culture]] and [[histological examination]] of the surgical [[specimen]] help to diagnose brodie`s abscess. | |||
==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
The combination of surgical [[debridement]] with [[antibiotics]] are the mainstay of treatment. | |||
===Surgical Therapy=== | ===Surgical Therapy=== | ||
[[Surgical debridement]] includes removal of all [[necrotic]], dead [[bones]] and infected granulation [[tissues]]. | |||
===Primary Prevention=== | ===Primary Prevention=== | ||
No data available for the primary prevention of brodie abscess. | |||
===Secondary Prevention=== | ===Secondary Prevention=== | ||
No data available for the secondary prevention of brodie abscess. | |||
Latest revision as of 08:17, 1 May 2023
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Brodie abscess Microchapters |
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Brodie abscess overview On the Web |
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Risk calculators and risk factors for Brodie abscess overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Abdulkerim Yassin, M.B.B.S[2]
Synonyms and keywords: Subacute Osteomyelitis
Overview
Brodie abscess is a rare subacute or acute chronic osteomyelitis with a pus-filled cavity, vascularized wall and hard sclerotic surrounding bone. It mostly involves the metaphysis of bones (especially tibia) but it can occur at any location and in a patients of any age. It classically presents with pain with out any other systemic symptoms. Thus making an accurate and timely diagnosis is usually difficult. It is usually mistaken with bone tumor. It has insidious onset and the inflammatory markers are unremarkable. Brodie abscess may be the result of inadequate treatment for acute osteomyelitis or may occur in the setting of a more strong host resistance to infection, inoculation with less virulent organisms, prior antibiotic exposure or a combination of these factors. Brodie's abscesses are mostly seen in children and adolescents with an average age of 19.5 years. The most commonly identified organism is staphylococcus aureus. Other pathogens such as Pseudomonas aeruginosa, Klebsiella spp., and Salmonella typhi have been reported. In about 25% of cases, no organism is identified. The patient may present with chronic pain in the affected area in the absence of trauma. Laboratory findings are mostly includes normal WBC with differential. Inflammatory markers such Erythrocyte sedimentation rate and C-reactive protein levels are may be normal or elevated in about half of the cases. Definitive diagnosis is made with radiological imaging. The mainstay of treatment is surgical debridementt combined with antibiotics.
Historical Perspectives
Brodie abscess is first described by a British surgeon, sir Benjamin Brodie, in 1832. Wiles reported Brodie abscesses as a specific form of osteomyelitis in 1951. Harris and Kirkaldy-Willis (1965) were the first to describe primary subacute osteomyelitis and present a radiograph diagnosing the condition.
Classification
Brodie abscess was first classified radiologically by Kirkaldy-Willis from East-Africa. The currently utilized classification system was initially proposed by Gledhill in 1973 and then modified by Roberts et al in 1982.
Type IA: Metaphyseal radiolucency without surrounding sclerosis. It may cause confusion with Eosinophilic granuloma. Type IB: Metaphyseal radiolucency with surrounding reactive bone. Type II: Metaphyseal radiolucency with cortical erosion. It resembles Osteosarcoma. Type III: Cortical diaphyseal radiolucency with periosteal reaction. It looks like Osteoid Osteoma. Type IV: Diaphyseal lesion with sub periosteal new bone formation. This type may have the appearance of “onion-skinning” and thus be confused with Ewing’s sarcoma. Type V: Epiphyseal radiolucency that may appear similar to a chondroblastoma. IT has similar appearance with Chondroblastoma. Type VI: Vertebral lesion that may mimic eosinophilic granuloma or tuberculous spondylitis.
Pathophysiology
Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. history of trauma is reported in 30% of patients. Brodie abscess arises where the bacteria and the host defenses are equally balanced.
Causes
Staphylococcus aureus is the most common pathogens identified, however it is only isolated in as few as 75% of cases.
Differentiating Brodie Abscess From Other Diseases
Other diseases such as osteoid osteoma, Langerhans cell histiocytosis, chondrosarcoma, eosinophilic granuloma or tuberculosis may have similar presentation with brodie abscess and need further investigations.
Epidemiology and Demographics
Brodie's abscesses is generally observed in patients younger than 25 years of age, mostly seen in children and adolescents with an average age of 19.5 years.
Risk Factors
The development of brodie`s abscess could be the result of many factors such as inadequate treatment of acute osteomyelitis or antibiotic resistance.
Natural History, Complications and Prognosis
Brodie`s abscess is a rare subacute osteomyelitis. It is usually located within the metaphysis of long bones although diaphyseal involvement is more common in adult. Tibia is the most commonly involved bone. If left untreated,, it may cause long term disability, fracture or amputation. Prognosis is excellent after effective treatment.
Diagnosis
History and Symptoms
Brodie's abscesses are mostly seen in children and adolescents. It has gradual onset and can be difficult to diagnose. It presents mainly with bone pain.
Physical Examinations
The main presenting physical signs are limping, swelling and erythema.
Laboratory Findings
Laboratory findings such as white blood cell count and differential usually shows normal. Erythrocyte sedimentation rate and C-reactive protein levels may be normal or could be elevated.
X-ray
The diagnosis is made mainly with radiological imaging.
CT Scan
CT-Scan reveals the same features as x-ray but additionally It enhances sinus tract and fistula to a joint or soft tissue.
MRI
Definitive diagnosis is made using MRI.
Other Imaging Findings
SPECT-CT is also used to diagnose brodie`s abscess.
Other Diagnostic Studies
Blood culture and histological examination of the surgical specimen help to diagnose brodie`s abscess.
Treatment
Medical Therapy
The combination of surgical debridement with antibiotics are the mainstay of treatment.
Surgical Therapy
Surgical debridement includes removal of all necrotic, dead bones and infected granulation tissues.
Primary Prevention
No data available for the primary prevention of brodie abscess.
Secondary Prevention
No data available for the secondary prevention of brodie abscess.