Breast cancer bone metastasis

Overview

Bone is the most common site of breast cancer recurrence , . Despite modern cancer therapy, up to two thirds of patients with bone metastasis will subsequently develop an skeletal-related event (sre), defined as any of pathologic fracture, a requirement for surgical intervention and palliative radiotherapy to bone lesions, hypercalcemia of malignancy, and spinal cord compression. Not only are sres associated with significant morbidity, they also negatively affect survival. Moreover, sres are associated with loss of mobility and social functioning, and reduction in quality of life.