Bone marrow disorders: Difference between revisions
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==Overview== | ==Overview== | ||
Bone marrow disorders are classified into [[congenital bone marrow disorders]] and [[acquired bone marrow disorders]]. | Bone marrow disorders are classified into [[congenital bone marrow disorders]] and [[acquired bone marrow disorders]]. | ||
==Definition of Terms== | |||
* '''Bone marrow suppression''': Reduced numbers of cells in bone marrow | |||
** '''Myelosuppression''': Reduced number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]) | |||
** '''Immunosuppression or lymphosuppression''': Reduced number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]) | |||
* '''Bone marrow proliferation''': Increased numbers of cells in bone marrow | |||
** '''Myeloproliferation''': Reduced number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]) | |||
** '''Immunoproliferation or lymphoproliferation''': Reduced number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]) | |||
==Classification== | ==Classification== | ||
Revision as of 14:46, 16 February 2015
For congenital bone marrow disorders click here.
For acquired bone marrow disorders click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.
Definition of Terms
- Bone marrow suppression: Reduced numbers of cells in bone marrow
- Myelosuppression: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunosuppression or lymphosuppression: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)
- Bone marrow proliferation: Increased numbers of cells in bone marrow
- Myeloproliferation: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunoproliferation or lymphoproliferation: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)
Classification
Shown below is an algorithm depicting the different classes of bone marrow disorders.
| Bone Marrow Disorders | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Myelosuppression | Immunosuppression | Myeloproliferation | Immunoproliferation | Multiple lineages | Single lineage | ||||||||||||||||||||||||||||||||||||||||||||||