Bone marrow disorders: Difference between revisions
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'''''For congenital bone marrow disorders click [[congenital bone marrow disorders|here]].'''''<br> | '''''For congenital bone marrow disorders, click [[congenital bone marrow disorders|here]].'''''<br> | ||
'''''For acquired bone marrow disorders click [[acquired bone marrow disorders|here]].''''' | '''''For acquired bone marrow disorders, click [[acquired bone marrow disorders|here]].''''' | ||
{{CMG}} | {{CMG}} {{AE}} {{YD}}; {{Rim}}; {{SSK}} | ||
==Overview== | ==Overview== | ||
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==Definition of Terms== | ==Definition of Terms== | ||
* '''Bone marrow suppression''': Reduced numbers of cells in bone marrow | * '''Bone marrow suppression''': Reduced numbers of cells in the bone marrow | ||
** '''Myelosuppression''': Reduced number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]) | ** '''Myelosuppression''': Reduced number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]) | ||
** '''Immunosuppression or lymphosuppression''': Reduced number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]) | ** '''Immunosuppression or lymphosuppression''': Reduced number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]) | ||
* '''Bone marrow proliferation''': Increased numbers of cells in bone marrow | * '''Bone marrow proliferation''': Increased numbers of cells in the bone marrow | ||
** '''Myeloproliferation''': Increased number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]) | ** '''Myeloproliferation''': Increased number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]) | ||
** '''Immunoproliferation or lymphoproliferation''': Increased number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]) | ** '''Immunoproliferation or lymphoproliferation''': Increased number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]) | ||
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{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | | | B01 | | | | | | | | | | | | B02 | | | B01= <div style="width: 10em">'''[[Acquired disorders of the bone marrow]]''' </div>|B02= <div style="width: 10em">'''[[Congenital disorders of the bone marrow]]''' </div>}} | {{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | | | B01 | | | | | | | | | | | | B02 | | | B01= <div style="width: 10em">'''[[Acquired disorders of the bone marrow]]''' </div>|B02= <div style="width: 10em">'''[[Congenital disorders of the bone marrow]]''' </div>}} | ||
{{Family tree | | | |,|-|-|-|^|-|-|-|v|-|-|-|.| | | |,|-|^|-|.| | }} | {{Family tree | | | |,|-|-|-|^|-|-|-|v|-|-|-|.| | | |,|-|^|-|.| | }} | ||
{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | C01 | | | | | | C02 | | C03 | | C04 | | C05 | C01= <div style="width: 7em">[[Bone Marrow Suppression|Bone marrow suppression]] </div>| C02= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Bone marrow proliferation]]</div>| C03= <div style="width: 7em">[[Acquired disorders of the bone marrow#Mixed or Unclassified Disorders|Mixed or unclassified]]</div>| C04= <div style="width: 7em">[[Congenital disorders of the bone marrow#Inherited Bone Marrow Failure Syndromes|Bone marrow suppression]]</div>| C05= <div style="width: 7em">[[Congenital disorders of the bone marrow#Proliferative Bone Marrow Failure Syndromes|Bone marrow proliferation]]</div>}} | {{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | C01 | | | | | | C02 | | C03 | | C04 | | C05 | C01= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Suppression|Bone marrow suppression]] </div>| C02= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Bone marrow proliferation]]</div>| C03= <div style="width: 7em">[[Acquired disorders of the bone marrow#Mixed or Unclassified Disorders|Mixed or unclassified]]</div>| C04= <div style="width: 7em">[[Congenital disorders of the bone marrow#Inherited Bone Marrow Failure Syndromes|Bone marrow suppression]]</div>| C05= <div style="width: 7em">[[Congenital disorders of the bone marrow#Proliferative Bone Marrow Failure Syndromes|Bone marrow proliferation]]</div>}} | ||
{{Family tree | |,|-|^|-|.| | | |,|-|^|-|.| | | |,|-|^|-|.| | | | }} | {{Family tree | |,|-|^|-|.| | | |,|-|^|-|.| | | |,|-|^|-|.| | | | }} | ||
{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | | D01= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Myelosuppression]]| D02= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Immunosuppression]]| D03= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Myeloproliferation]]| D04= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Immunoproliferation]]| D05= [[Congenital disorders of the bone marrow#Multiple Lineages Defect|Multiple lineages]]| D06= [[Congenital disorders of the bone marrow#Single Lineage Defect|Single lineage]]}} | {{Family tree |boxstyle= padding: 0; background: #DCDCDC; | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | | D01= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Myelosuppression]]| D02= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Immunosuppression]]| D03= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Myeloproliferation]]| D04= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Immunoproliferation]]| D05= [[Congenital disorders of the bone marrow#Multiple Lineages Defect|Multiple lineages]]| D06= [[Congenital disorders of the bone marrow#Single Lineage Defect|Single lineage]]}} | ||
Latest revision as of 23:33, 20 August 2015
For congenital bone marrow disorders, click here.
For acquired bone marrow disorders, click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.
Overview
Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.
Definition of Terms
- Bone marrow suppression: Reduced numbers of cells in the bone marrow
- Myelosuppression: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunosuppression or lymphosuppression: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)
- Bone marrow proliferation: Increased numbers of cells in the bone marrow
- Myeloproliferation: Increased number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunoproliferation or lymphoproliferation: Increased number of lymphoid lineage cells (T-cell, B-cell, NK cell)
Classification
Shown below is an algorithm depicting the different classes of bone marrow disorders.
| Bone Marrow Disorders | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Myelosuppression | Immunosuppression | Myeloproliferation | Immunoproliferation | Multiple lineages | Single lineage | ||||||||||||||||||||||||||||||||||||||||||||||