Bone marrow disorders: Difference between revisions

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'''''For congenital bone marrow disorders click [[congenital bone marrow disorders|here]].'''''<br>
'''''For congenital bone marrow disorders, click [[congenital bone marrow disorders|here]].'''''<br>
'''''For acquired bone marrow disorders click [[acquired bone marrow disorders|here]].'''''
'''''For acquired bone marrow disorders, click [[acquired bone marrow disorders|here]].'''''


{{CMG}}; {{AE}} {{Rim}}; {{YD}}; {{SSK}}
{{CMG}} {{AE}} {{YD}}; {{Rim}}; {{SSK}}


==Overview==
==Overview==
Bone marrow disorders are classified into [[congenital bone marrow disorders]] and [[acquired bone marrow disorders]].
Bone marrow disorders are classified into [[congenital bone marrow disorders]] and [[acquired bone marrow disorders]].
==Definition of Terms==
* '''Bone marrow suppression''': Reduced numbers of cells in the bone marrow
** '''Myelosuppression''': Reduced number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]])
** '''Immunosuppression or lymphosuppression''': Reduced number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]])
* '''Bone marrow proliferation''': Increased numbers of cells in the bone marrow
** '''Myeloproliferation''': Increased number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]])
** '''Immunoproliferation or lymphoproliferation''': Increased number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]])


==Classification==
==Classification==
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{{Family tree |boxstyle= padding: 0; background: #FFA07A;| | | | | | | | | | | | | | A01 | | | | | | | | | | A01= '''Bone Marrow Disorders'''}}
{{Family tree |boxstyle= padding: 0; background: #FFA07A;| | | | | | | | | | | | | | A01 | | | | | | | | | | A01= '''Bone Marrow Disorders'''}}
{{Family tree | | | | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|.| | | | }}
{{Family tree | | | | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|.| | | | }}
{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | | | B01 | | | | | | | | | | | | B02 | | | B01= <div style="width: 10em">'''[[Congenital disorders of the bone marrow]]''' </div>| B02= <div style="width: 10em">'''[[Acquired disorders of the bone marrow]]''' </div>}}
{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | | | B01 | | | | | | | | | | | | B02 | | | B01= <div style="width: 10em">'''[[Acquired disorders of the bone marrow]]''' </div>|B02= <div style="width: 10em">'''[[Congenital disorders of the bone marrow]]''' </div>}}
{{Family tree | | | |,|-|-|-|^|-|-|-|v|-|-|-|.| | | |,|-|^|-|.| | }}
{{Family tree | | | |,|-|-|-|^|-|-|-|v|-|-|-|.| | | |,|-|^|-|.| | }}
{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | C01 | | | | | | C02 | | C03 | | C04 | | C05 | C01= <div style="width: 7em">Bone marrow suppression </div>| C02= <div style="width: 7em">Bone marrow proliferation</div>| C03= <div style="width: 7em">Mixed or unclassified</div>| C04= <div style="width: 7em">Inherited bone marrow failure syndromes</div>| C05= <div style="width: 7em">Inherited bone marrow proliferative syndromes</div>}}
{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | C01 | | | | | | C02 | | C03 | | C04 | | C05 | C01= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Suppression|Bone marrow suppression]] </div>| C02= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Bone marrow proliferation]]</div>| C03= <div style="width: 7em">[[Acquired disorders of the bone marrow#Mixed or Unclassified Disorders|Mixed or unclassified]]</div>| C04= <div style="width: 7em">[[Congenital disorders of the bone marrow#Inherited Bone Marrow Failure Syndromes|Bone marrow suppression]]</div>| C05= <div style="width: 7em">[[Congenital disorders of the bone marrow#Proliferative Bone Marrow Failure Syndromes|Bone marrow proliferation]]</div>}}
{{Family tree | |,|-|^|-|.| | | |,|-|^|-|.| | | |,|-|^|-|.| | | | }}
{{Family tree | |,|-|^|-|.| | | |,|-|^|-|.| | | |,|-|^|-|.| | | | }}
{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | | D01= Myelosuppression| D02= Immunosuppression| D03= Myeloproliferative| D04= Immunoproliferative| D05= Multiple lineages| D06= Single lineage}}
{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | | D01= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Myelosuppression]]| D02= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Immunosuppression]]| D03= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Myeloproliferation]]| D04= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Immunoproliferation]]| D05= [[Congenital disorders of the bone marrow#Multiple Lineages Defect|Multiple lineages]]| D06= [[Congenital disorders of the bone marrow#Single Lineage Defect|Single lineage]]}}
{{Family tree/end}}
{{Family tree/end}}



Latest revision as of 23:33, 20 August 2015

For congenital bone marrow disorders, click here.
For acquired bone marrow disorders, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

Overview

Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.

Definition of Terms

Classification

Shown below is an algorithm depicting the different classes of bone marrow disorders.

 
 
 
 
 
 
 
 
 
 
 
 
 
Bone Marrow Disorders
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Myelosuppression
 
Immunosuppression
 
Myeloproliferation
 
Immunoproliferation
 
Multiple lineages
 
Single lineage
 
 

References