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|[[Bloating resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
|[[Bloating resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
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{{Infobox_Disease |
 
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  ICD10          = {{ICD10|R|14|r|10}}|
  ICD9          = {{ICD9|787.3}}|
  ICDO          = |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = |
  eMedicineTopic = |
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{{SI}}
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{{CMG}} '''Associate Editor-In-Chief:''' {{Ibtisam}}
{{CMG}} '''Associate Editor-In-Chief:''' {{Ibtisam}}
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==Pathophysiology==
==Pathophysiology==
===Abnormal Gut Microbiota===
===Abnormal Gut Microbiota===
There is a relationship between the types of gas produced by colonic [[microflora]] and bloating. The role of [[Methanogen|methanogenic flora]] has always been in question when the pathogenesis of bloating is discussed. During the experiments involving ingestion of [[sorbitol]] and fiber, it was determined that there was significant increase in bloating in individuals with low producers of [[methane]] vs high producers. <ref name="pmid8995944">{{cite journal |vauthors=Kajs TM, Fitzgerald JA, Buckner RY, Coyle GA, Stinson BS, Morel JG, Levitt MD |title=Influence of a methanogenic flora on the breath H2 and symptom response to ingestion of sorbitol or oat fiber |journal=Am. J. Gastroenterol. |volume=92 |issue=1 |pages=89–94 |date=January 1997 |pmid=8995944 |doi= |url=}}</ref>
There is a relationship between the types of gas produced by colonic [[microflora]] and bloating. The role of [[Methanogen|methanogenic flora]] has always been in question when the pathogenesis of bloating is discussed. During the experiments involving the ingestion of [[sorbitol]] and fiber, it was determined that there was a significant increase in bloating in individuals with low producers of [[methane]] vs high producers. <ref name="pmid8995944">{{cite journal |vauthors=Kajs TM, Fitzgerald JA, Buckner RY, Coyle GA, Stinson BS, Morel JG, Levitt MD |title=Influence of a methanogenic flora on the breath H2 and symptom response to ingestion of sorbitol or oat fiber |journal=Am. J. Gastroenterol. |volume=92 |issue=1 |pages=89–94 |date=January 1997 |pmid=8995944 |doi= |url=}}</ref>


===Small Intestinal Bacterial Overgrowth===
===Small Intestinal Bacterial Overgrowth===
Line 65: Line 52:


==Clinical Features==
==Clinical Features==
Some people experience signs of [[irritable bowel syndrome]], [[functional dyspepsia]], [[constipation]], or [[premenstrual syndrome]]. They may have psychiatric or emotional problems, too. Recent weight gain, weak abdominal muscles, and lack of exercise is common. The distention is noticeable to the patient, the family, the friends and the doctor. Patient is typically a woman who complains of occasional abdominal swelling that worsens with large / heavy meals and loosening the belt or changing clothes, burping or [[defecation]] may improve symptoms.
Some people experience signs of [[irritable bowel syndrome]], [[functional dyspepsia]], [[constipation]], or [[premenstrual syndrome]]. They may have psychiatric or emotional problems, too. Recent weight gain, weak abdominal muscles, and lack of exercise are common. The distention is noticeable to the patient, the family, the friends, and the doctor. The patient is typically a woman who complains of occasional abdominal swelling that worsens with large/heavy meals and loosening the belt or changing clothes, burping, or [[defecation]] may improve symptoms.


==Causes==
==Causes==
Line 105: Line 92:


===History and Symptoms===
===History and Symptoms===
History includes the onset of symptoms, the relationship to diet (eg, wheat, dairy, fructose, fiber, non absorbable sugars) diurnal variation, and the presence of symptoms suggestive of other functional gastrointestinal disorders, including [[constipation]], diarrhea, and abdominal pain or postprandial fullness. Functional bloating usually has a [[diurnal]] pattern which may accompanies the consumption of such foods, frequently accompanied by excessive [[burping]] or flattening. Patients may complain about deteriorating symptoms as the day progresses, particularly after meals, but they may be relieved overnight.<ref name="pmid16678560">{{cite journal |vauthors=Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V |title=Functional gastroduodenal disorders |journal=Gastroenterology |volume=130 |issue=5 |pages=1466–79 |date=April 2006 |pmid=16678560 |doi=10.1053/j.gastro.2005.11.059 |url=}}</ref>
History includes the onset of symptoms, the relationship to diet (eg, wheat, dairy, fructose, fiber, nonabsorbable sugars) diurnal variation, and the presence of symptoms suggestive of other functional gastrointestinal disorders, including [[constipation]], diarrhea, and abdominal pain or postprandial fullness. Functional bloating usually have a [[diurnal]] pattern which may accompany the consumption of such foods, frequently accompanied by excessive [[burping]] or flattening. Patients may complain about deteriorating symptoms as the day progresses, particularly after meals, but they may be relieved overnight.<ref name="pmid16678560">{{cite journal |vauthors=Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V |title=Functional gastroduodenal disorders |journal=Gastroenterology |volume=130 |issue=5 |pages=1466–79 |date=April 2006 |pmid=16678560 |doi=10.1053/j.gastro.2005.11.059 |url=}}</ref>


===Physical Examination===
===Physical Examination===
Line 208: Line 195:
[[Category:Digestive disease symptoms]]
[[Category:Digestive disease symptoms]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
 
[[Category:Primary care]]
 
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Revision as of 14:46, 9 October 2020



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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Ibtisam Ashraf, M.B.B.S.[2]

Overview

Bloating is described as a sensation of elevated abdominal pressure that may or may not be accompanied by objective abdominal distension, i.e. noticeable enlargement of the waist. Bloating and abdominal distension may be symptoms of organic disease and possible causes should be considered first in the differential diagnosis. It is one of the most frequent problems in a wide proportion of patients with gastrointestinal disorders, but the most common cause is constipation. Bloating also results from irritable bowel syndrome, gastroparesis, small intestinal bacterial overgrowth and gynecological conditions. The pathophysiology of bloating is not well understood and suggested underlying causes include visceral hypersensitivity, behavioral mediated irregular abdominal wall-phrenic reflexes, the influence of poorly ingested fermentable carbohydrates, and microbiome modification. Usually, patients are evaluated with a thorough history and physical examination, but organic disorders should be ruled out. The management strategy includes dietary modification, behavioral therapy, microbiome modulation, and medical therapy.

Historical Perspective

  • Bernheim in 1891 described a woman who said, "I go up and down like an accordion."[1] and Later on in 1900 Kaplan, wrote on ventre en accordéon.[2]
  • Nongaseous form of bloating was first described by Sir James Y. Simpson. [3]
  • According to Kaplan, in the 19th century in Europe, the intestines of the patient were punctured with a trocar in cases of suspected intestinal obstruction. In this way, it was discovered that there was no gas involved in cases of hysteric bloating.
  • It was also considered a "tumor" that vanished when the patient was anesthetized and returned when they were conscious.[4]
  • Lordosis association with bloating was described by Krukenberg in 1884. [2]
  • Bloating was first described by Alvarez of the Mayo Clinic in 1949 in a woman with a psychiatric problem.[2]

Classification

There is no established system for the classification of bloating.

Pathophysiology

Abnormal Gut Microbiota

There is a relationship between the types of gas produced by colonic microflora and bloating. The role of methanogenic flora has always been in question when the pathogenesis of bloating is discussed. During the experiments involving the ingestion of sorbitol and fiber, it was determined that there was a significant increase in bloating in individuals with low producers of methane vs high producers. [5]

Small Intestinal Bacterial Overgrowth

Patients with IBS who explicitly complain of bloating have been reported to have elevated gas production from bacterial fermentation due to small intestinal bacterial overgrowth (SIBO).[6]

Intestinal Gas Accumulation

Increase levels of intestinal gas has been linked with bloating. After consuming a large meal there is 65% increase in postprandial gas volume in pelvic colon, where as during fasting, GI tract produces about 100ml of gas which spreads between liver, small intestine, ascending colon, transverse colon, descending colon, and distal (pelvic) colon.[7]

Altered Gut Motility

Gut motility is affected in many disorders mainly labeled as Intestinal dysmotility. It affects the evacuation of excessive gas produced in the GI tract during fasting as well as post-prandial.

Abnormal Abdominal-diaphragmatic Reflexes

Mechanism which leads to bloating are not well understood but studies have shown a role of abdominal-diaphragmatic reflexes, which are involves the combination of increase in the anterior wall tone and diaphragm relaxation. These reflexes are abnormal in individuals with bloating.[8]

Visceral Hypersensitivity

The sensation of bloating may originate from abdominal viscera in patients with a functional gastrointestinal disorder, in whom normal stimuli or small variations of gas content within the gut may be perceived as bloating. The autonomic nervous system may also contribute to the modulation of visceral sensitivity and sympathetic activation is known to increase the perception of intestinal distention in these patients.

Food Intolerance and Carbohydrate Malabsorption

A high FODMAP diet has demonstrated prolonged hydrogen production in the intestine, colonic distension by fermentation, increased colonic fluid delivery by osmotic load within the bowel lumen, and GI symptom generation. [9]

Hard stool/Constipation

Distension of the rectum by retained feces induces alteration of gut motility and increases bacterial fermentation.

Clinical Features

Some people experience signs of irritable bowel syndrome, functional dyspepsia, constipation, or premenstrual syndrome. They may have psychiatric or emotional problems, too. Recent weight gain, weak abdominal muscles, and lack of exercise are common. The distention is noticeable to the patient, the family, the friends, and the doctor. The patient is typically a woman who complains of occasional abdominal swelling that worsens with large/heavy meals and loosening the belt or changing clothes, burping, or defecation may improve symptoms.

Causes

The most common cause of bloating is Constipation, Pregnancy, IBS, Celiac disease, Lactose, fructose, and other carbohydrates intolerance, Pancreatic insufficiency, Gastroparesis, Diabetes mellitus, Hypothyroidism, Scleroderma, Chronic idiopathic pseudo-obstruction, Small bowel bacterial overgrowth, Acute gastroenteritis, Gastric malignancy, Ovarian malignancy, and Ascites.[10]

Differentiating bloating from other Diseases

Bloating must be differentiated from Lactose intolerance, Fructose intolerance, Celiac disease, Pancreatic insufficiency, Irritable bowel syndrome, Functional dyspepsia, Functional bloating, Constipation, Diabetes, Scleroderma, Pseudo-obstruction: acute or chronic, Gastroparesis, Acute adynamic ileus, Gastric outlet obstruction, Small bowel obstruction, SMA syndrome, Colonic obstruction, Volvulus, Gastrointestinal/Ovarian Malignancy, Ascites, Pregnancy, and Obesity/adiposity.[11]

Epidemiology and Demographics

  • In the USA, 15-30% of the general population has been reported to experience bloating.[12]
  • A telephone survey reported a prevalence of 16% in US adults who were asked about bloating or distention during the last month.[13]
  • Women were more likely than men to report bloating.[12]
  • There is no racial predilection to bloating.[14]

Risk Factors

Risk factors include chewing gum, hard candy, and carbonated beverages such as soda or beer. Foods that can produce excess bowel gas include leafy greens, beans, and bran foods. Dairy products can lead to bloating and flatulence in people who are lactose intolerant.

Screening

There is insufficient evidence to recommend routine screening for bloating.

Natural History, Complications, and Prognosis

The sensation of abdominal bloating is often attributed to excessive gas in patients. However, the relationship between the volume of intestinal gas and the effects is not clear. Patients with chronic complaints of bloating and distension have heightened sensitivity to gaseous distension or exaggerated motor response to normal amounts of gas. Pains that are due to bloating will feel sharp and cause the stomach to cramp. These pains may occur anywhere in the body and can change locations quickly.

Bloating is typically benign, although it can be due to severe conditions such as intestinal obstruction and malignancy.

Patients with mild functional bloating may need merely reassurance that the condition is benign. [10]

Diagnosis

Diagnostic Study of Choice

Rome IV criteria for establishing the diagnosis of functional bloating include both of the following (for at least three months with symptom onset at least six months prior to diagnosis).[15]

●Recurrent bloating or distension, on average, at least one day per week; abdominal bloating and/or distension predominates over other symptoms

●Insufficient criteria for a diagnosis of IBS, functional constipation, functional diarrhea, or postprandial distress syndrome

History and Symptoms

History includes the onset of symptoms, the relationship to diet (eg, wheat, dairy, fructose, fiber, nonabsorbable sugars) diurnal variation, and the presence of symptoms suggestive of other functional gastrointestinal disorders, including constipation, diarrhea, and abdominal pain or postprandial fullness. Functional bloating usually have a diurnal pattern which may accompany the consumption of such foods, frequently accompanied by excessive burping or flattening. Patients may complain about deteriorating symptoms as the day progresses, particularly after meals, but they may be relieved overnight.[16]

Physical Examination

Common physical examination findings of bloating include abdominal distention with or without altered bowel sounds. However, if occult fecal blood, cutaneous findings (sclerodactyly with scleroderma, dermatitis herpetiformis in celiac disease), peripheral or autonomic neuropathy, cachexia, jaundice, or palpable masses is present then it suggests underlying organic disease. [11]

Laboratory Findings

Complete blood count

To evaluate for anemia

Serologies for Celiac Sprue[17]

  • anti-tissue transglutaminase (tTG) antibodies
  • endomysial antibodies (EMA)
  • deamidated gliadin peptide (DGP) antibodies

Hydrogen Breath Test

For the evaluation of small intestinal bacterial overgrowth and lactose intolerance.

Thyroid Function tests[18]

Fasting Cortisol Levels[19]

Antinuclear antibodies and Scleroderma antibodies[20]

To evaluate for collagen vascular disease

Antinuclear neuronal antibodies[21]

To screen for paraneoplastic visceral neuropathy

Stool analysis

Antigen testing for Giardia

Electrocardiogram

There are no ECG findings associated with bloating.

X-ray

An abdominal x-ray may be helpful to rule out intestinal obstruction.

Echocardiography or Ultrasound

Abdominal/Pelvic Ultrasound to look for ascites and rule out ovarian cancer.

CT scan

There are no CT scan findings associated with bloating. However, it can be used to rule out intestinal obstruction.

MRI

There are no MRI findings associated with bloating.

Other Imaging Findings

Upper GI Endoscopy

The presence of alarm features including weight loss, abdominal pain, dysphagia, heartburn, and regurgitation are an indication for a diagnostic evaluation with upper endoscopy.

Other Diagnostic Studies

There are no other diagnostic studies associated with bloating.

Treatment

Medical Therapy

Education, treatment of associated disorders, and behavioral therapy

Management requires instruction to minimize air swallowing and reassurance that belching is a benign condition. Relevant behavioural interventions include the avoidance of gum chewing, smoking, consuming carbonated drinks, and gulping of food and liquids. Treatment should be started in people with persistent depression or anxiety.[22] Patients with co-existing acid reflux may need an acid reduction treatment for the control of GERD.

Effective management with excessive belching by a therapist (e.g. cognitive behavioral therapy or speech therapist)[23] with specific experience of diaphragmatic relaxation exercises has been linked with a decrease of symptoms.   Diaphragmatic breathing decreases postprandial intragastric pressure and raises the pressure of the esophagogastric junction region, restoring the gradient of the gastroesophageal pressure.

Reflux inhibitors for refractory symptoms

Baclofen (10 mg three times daily) by reducing transient lower esophageal sphincter relaxations and centrally suppressing the swallowing rate, may decrease both supragastric and gastric belching. [24]


 
 
 
 
 
 
 
Abdominal Bloating
and
Distension
[10]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Evaluate for:
●Alarm Signs
●Overlapping FGID
(FG,FD,IBS)
Bacterial Overgrowth
●Dietary Intolerance
Celiac Disease
●Recent Weight Gain
Constipation
●Psychological disorder
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No
 
 
 
 
 
 
 
Yes
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
●Reassurance
●Recommend
Diaphragmatic
Breathing
●Diet Intervention:
Low FODMAP diet
●Symptomatic
medical therapy:
Peppermint oil,
Simethicone etc
 
 
 
 
 
 
 
Treat
Accordingly
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No Response
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
●Trial of
Rifixamin/Probiotics
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No Response
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
●Antidepressants
●Psychological therapy
Hypnotherapy,
CBT
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
No Response
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
●Refer to
Neurogastroenterology
center
●Refer to CT
or
MRI Electromyography
●Refer to Abdominal
Biofeedback
therapy
 
 
 
 
 
 
 
 
 
 
 
 

Surgery

Surgical intervention is not recommended for the management of bloating.

Primary Prevention

There are no established measures for the primary prevention of bloating.

Secondary Prevention

There are no established measures for the secondary prevention of bloating.

References

  1. Schott H (1984). "[Mesmer, Braid and Bernheim: on the history of the development of hypnotism]". Gesnerus (in German). 41 (1–2): 33–48. PMID 6378725.
  2. 2.0 2.1 2.2 ALVAREZ WC (August 1949). "Hysterical type of nongaseous abdominal bloating". Arch Intern Med (Chic). 84 (2): 217–45. doi:10.1001/archinte.1949.00230020020002. PMID 18138437.
  3. Dunn PM (May 2002). "Sir James Young Simpson (1811-1870) and obstetric anaesthesia". Arch. Dis. Child. Fetal Neonatal Ed. 86 (3): F207–9. doi:10.1136/fn.86.3.f207. PMC 1721404. PMID 11978757.
  4. "February 1887 - Volume 14 - Issue 2 : The Journal of Nervous and Mental Disease".
  5. Kajs TM, Fitzgerald JA, Buckner RY, Coyle GA, Stinson BS, Morel JG, Levitt MD (January 1997). "Influence of a methanogenic flora on the breath H2 and symptom response to ingestion of sorbitol or oat fiber". Am. J. Gastroenterol. 92 (1): 89–94. PMID 8995944.
  6. Pimentel M, Park S, Mirocha J, Kane SV, Kong Y (October 2006). "The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial". Ann. Intern. Med. 145 (8): 557–63. doi:10.7326/0003-4819-145-8-200610170-00004. PMID 17043337.
  7. "Sleisenger and Fordtran's Gastrointestinal and Liver Disease- 2 Volume Set - 9th Edition".
  8. Accarino A, Perez F, Azpiroz F, Quiroga S, Malagelada JR (May 2009). "Abdominal distention results from caudo-ventral redistribution of contents". Gastroenterology. 136 (5): 1544–51. doi:10.1053/j.gastro.2009.01.067. PMID 19208364.
  9. Barrett JS, Gearry RB, Muir JG, Irving PM, Rose R, Rosella O, Haines ML, Shepherd SJ, Gibson PR (April 2010). "Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon". Aliment. Pharmacol. Ther. 31 (8): 874–82. doi:10.1111/j.1365-2036.2010.04237.x. PMID 20102355.
  10. 10.0 10.1 10.2 Mari A, Abu Backer F, Mahamid M, Amara H, Carter D, Boltin D, Dickman R (May 2019). "Bloating and Abdominal Distension: Clinical Approach and Management". Adv Ther. 36 (5): 1075–1084. doi:10.1007/s12325-019-00924-7. PMC 6824367 Check |pmc= value (help). PMID 30879252.
  11. 11.0 11.1 Hasler WL (September 2006). "Gas and Bloating". Gastroenterol Hepatol (N Y). 2 (9): 654–662. PMC 5350578. PMID 28316536.
  12. 12.0 12.1 Jiang X, Locke GR, Choung RS, Zinsmeister AR, Schleck CD, Talley NJ (June 2008). "Prevalence and risk factors for abdominal bloating and visible distention: a population-based study". Gut. 57 (6): 756–63. doi:10.1136/gut.2007.142810. PMC 2581929. PMID 18477677.
  13. Sandler RS, Stewart WF, Liberman JN, Ricci JA, Zorich NL (June 2000). "Abdominal pain, bloating, and diarrhea in the United States: prevalence and impact". Dig. Dis. Sci. 45 (6): 1166–71. doi:10.1023/a:1005554103531. PMID 10877233.
  14. Ho KY, Kang JY, Seow A (October 1998). "Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms". Am. J. Gastroenterol. 93 (10): 1816–22. doi:10.1111/j.1572-0241.1998.00526.x. PMID 9772037.
  15. Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R (February 2016). "Bowel Disorders". Gastroenterology. doi:10.1053/j.gastro.2016.02.031. PMID 27144627.
  16. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V (April 2006). "Functional gastroduodenal disorders". Gastroenterology. 130 (5): 1466–79. doi:10.1053/j.gastro.2005.11.059. PMID 16678560.
  17. Mari A, Abu Backer F, Mahamid M, Amara H, Carter D, Boltin D, Dickman R (May 2019). "Bloating and Abdominal Distension: Clinical Approach and Management". Adv Ther. 36 (5): 1075–1084. doi:10.1007/s12325-019-00924-7. PMC 6824367 Check |pmc= value (help). PMID 30879252.
  18. Mari A, Abu Backer F, Mahamid M, Amara H, Carter D, Boltin D, Dickman R (May 2019). "Bloating and Abdominal Distension: Clinical Approach and Management". Adv Ther. 36 (5): 1075–1084. doi:10.1007/s12325-019-00924-7. PMC 6824367 Check |pmc= value (help). PMID 30879252.
  19. Mari A, Abu Backer F, Mahamid M, Amara H, Carter D, Boltin D, Dickman R (May 2019). "Bloating and Abdominal Distension: Clinical Approach and Management". Adv Ther. 36 (5): 1075–1084. doi:10.1007/s12325-019-00924-7. PMC 6824367 Check |pmc= value (help). PMID 30879252.
  20. Mari A, Abu Backer F, Mahamid M, Amara H, Carter D, Boltin D, Dickman R (May 2019). "Bloating and Abdominal Distension: Clinical Approach and Management". Adv Ther. 36 (5): 1075–1084. doi:10.1007/s12325-019-00924-7. PMC 6824367 Check |pmc= value (help). PMID 30879252.
  21. Mari A, Abu Backer F, Mahamid M, Amara H, Carter D, Boltin D, Dickman R (May 2019). "Bloating and Abdominal Distension: Clinical Approach and Management". Adv Ther. 36 (5): 1075–1084. doi:10.1007/s12325-019-00924-7. PMC 6824367 Check |pmc= value (help). PMID 30879252.
  22. Disney B, Trudgill N (April 2014). "Managing a patient with excessive belching". Frontline Gastroenterol. 5 (2): 79–83. doi:10.1136/flgastro-2013-100355. PMC 5369716. PMID 28839757.
  23. Hemmink GJ, Ten Cate L, Bredenoord AJ, Timmer R, Weusten BL, Smout AJ (January 2010). "Speech therapy in patients with excessive supragastric belching--a pilot study". Neurogastroenterol. Motil. 22 (1): 24–8, e2–3. doi:10.1111/j.1365-2982.2009.01371.x. PMID 19650772.
  24. Blondeau K, Boecxstaens V, Rommel N, Farré R, Depeyper S, Holvoet L, Boeckxstaens G, Tack JF (April 2012). "Baclofen improves symptoms and reduces postprandial flow events in patients with rumination and supragastric belching". Clin. Gastroenterol. Hepatol. 10 (4): 379–84. doi:10.1016/j.cgh.2011.10.042. PMID 22079512.


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