Autoimmune hepatitis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History
- The majority of patients with Autoimmune hepatitis are asymptomatic leads to severe symptoms and progresses even to fulminant hepatitis.
- Autoimmune hepatitis can present as acute hepatitis, chronic hepatitis, or well-established cirrhosis. Autoimmune hepatitis can rarely present as the fulminant hepatic failure.
- The hallmark of Autoimmune hepatitis is fatigue and jaundice.
- A positive history of fatigue and jaundice is suggestive of Autoimmune hepatitis.
History
Obtaining the history is the most important aspect of making a diagnosis of Autoimmune hepatitis. It provides insight into the cause, precipitating factors and associated autoimmune conditions.
Past Medical History
- A history of epigastric pain, dyspepsia, or prior peptic ulcer may suggest the diagnosis of peptic ulcer disease.[1][2][3]
Medication History
- Prior use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) is important because these patients have an increased risk of gastric ulcer and a fourfold risk of significant GI bleeding compared with other patients[4]
Social History
- Helicobacter pylori infection is more common in low socioeconomic status and increased number of siblings[5]
- Alcoholics also frequently have peptic ulcers or gastritis[6][4]
- Cigarette smokers have a significantly higher rate of the recurrent duodenal ulcer as compared with nonsmokers [7][8]
Family History
- Family history of peptic ulcer disease increases the risk of peptic ulcer
- History of peptic ulcer disease in mother increases the risk of peptic ulcer disease in children
Common Symptoms
Common symptoms of Autoimmune hepatitis include:[9][10][11][12][13]
- Fatigue
- Lethargy
- Upper abdominal discomfort
- Mild pruritus
- Anorexia
- Myalgia
- Diarrhea
- Arthralgias involving small joints
- Dark urine
- Pale or gray-colored stools
- skin rashes
- Weight loss
Less Common Symptoms
Less common symptoms of Autoimmune hepatitis include :
- Edema
- Acne
- Hirsutism
- Amenorrhea
- Chest pain from pleuritis
- Extrahepatic manifestations are generally due to the company that AH keeps:
- Chronic autoimmune thyroiditis
- Hyperthyroidism (Graves’ disease)
- Ulcerative colitis
- Hemolytic anemia
- Idiopathic thrombocytopenia
- Diabetes mellitus
- Diabetes insipidus
- Celiac disease
- Polymyositis
- Myasthenia gravis
- Pulmonary fibrosis
- Pericarditis
- Glomerulonephritis
- Acute lichenoid pityriasis
- Febrile panniculitis
- Hypereosinophilic syndrome
- Sjogren’s syndrome
- Mixed connective tissue disease
References
- ↑ Laine, Loren; Solomon, Caren G. (2016). "Upper Gastrointestinal Bleeding Due to a Peptic Ulcer". New England Journal of Medicine. 374 (24): 2367–2376. doi:10.1056/NEJMcp1514257. ISSN 0028-4793.
- ↑ Ramakrishnan K, Salinas RC (2007). "Peptic ulcer disease". Am Fam Physician. 76 (7): 1005–12. PMID 17956071.
- ↑ Drini M (2017). "Peptic ulcer disease and non-steroidal anti-inflammatory drugs". Aust Prescr. 40 (3): 91–93. doi:10.18773/austprescr.2017.037. PMC 5478398. PMID 28798512.
- ↑ 4.0 4.1 Goulston K, Cooke AR (1968). "Alcohol, aspirin, and gastrointestinal bleeding". Br Med J. 4 (5632): 664–5. PMC 1912769. PMID 5303551.
- ↑ Bruce MG, Maaroos HI (2008). "Epidemiology of Helicobacter pylori infection". Helicobacter. 13 Suppl 1: 1–6. doi:10.1111/j.1523-5378.2008.00631.x. PMID 18783514.
- ↑ MacMath TL (1990). "Alcohol and gastrointestinal bleeding". Emerg. Med. Clin. North Am. 8 (4): 859–72. PMID 2226291.
- ↑ Jafar W, Jafar A, Sharma A (2016). "Upper gastrointestinal haemorrhage: an update". Frontline Gastroenterol. 7 (1): 32–40. doi:10.1136/flgastro-2014-100492. PMC 5369541. PMID 28839832. Vancouver style error: initials (help)
- ↑ Palmer K (2007). "Acute upper gastrointestinal haemorrhage". Br. Med. Bull. 83: 307–24. doi:10.1093/bmb/ldm023. PMID 17942452.
- ↑ Makol A, Watt KD, Chowdhary VR (2011). "Autoimmune hepatitis: a review of current diagnosis and treatment". Hepat Res Treat. 2011: 390916. doi:10.1155/2011/390916. PMC 3132488. PMID 21760995.
- ↑ Kim BH, Kim YJ, Jeong SH, Tak WY, Ahn SH, Lee YJ, Jung EU, Lee JI, Yeon JE, Hwang JS, Um SH, Seo YS, Kim YS, Song BC, Kim JH, Jung YK, Park CK, Kim KA, Min HJ, Cho EY, Lee ES, Kwon SY, Chae HB, Kim DJ, Shin SR (2013). "Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: a nationwide, multicenter study". J. Gastroenterol. Hepatol. 28 (1): 128–34. doi:10.1111/j.1440-1746.2012.07292.x. PMID 23033899.
- ↑ Miyake Y, Iwasaki Y, Takaki A, Kobashi H, Sakaguchi K, Shiratori Y (2007). "Clinical features of Japanese elderly patients with type 1 autoimmune hepatitis". Intern. Med. 46 (24): 1945–9. PMID 18084114.
- ↑ Bellomo-Brandão MA, Costa-Pinto EA, De Tommaso AM, Hessel G (2006). "Clinical and biochemical features of autoimmune hepatitis in 36 pediatric patients". Arq Gastroenterol. 43 (1): 45–9. doi:/S0004-28032006000100012 Check
|doi=value (help). PMID 16699618. - ↑ Yasui S, Fujiwara K, Yonemitsu Y, Oda S, Nakano M, Yokosuka O (2011). "Clinicopathological features of severe and fulminant forms of autoimmune hepatitis". J. Gastroenterol. 46 (3): 378–90. doi:10.1007/s00535-010-0316-3. PMID 20821236.