Autoimmune hemolytic anemia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S; Shyam Patel [2]

Overview

In 1958, Leslie Zieve conducted a retrospective study on patients with alcoholic liver disease who had hemolytic anemia.^[1]

In 1968, Balcerzak confirmed the phenomenon of hemolytic anemia in conjunction with cholestatic jaundice and hypercholesterolemia.^[1]

In 1973, Playfair and Marshall-Clarke developed a murine model of autoimmune hemolytic anemia. In this murine model, the mice developed autoantibodies against their own red blood cells upon injection of rat red blood cells. The rat red blood cells triggered antibody production, since the rat antigens were foreign, but the antibodies also reacted against self antigens (murine antigens) also ^[2] Clinically, the mice developed anemia, elevated reticulocyte count, and positive direct antiglobulin test (Coomb's test). The mice had decreased survival.^[2]