Atypical teratoid rhabdoid tumor natural history, complications and prognosis: Difference between revisions

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Latest revision as of 18:39, 16 May 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

If left untreated, patients with atypical teratoid rhabdoid tumor may progress to develop obstructive hydrocephalus, leptomeningeal dissemination, and ultimately death. Common complications of atypical teratoid rhabdoid tumor include obstructive hydrocephalus, leptomeningeal dissemination, and recurrence. Prognosis is generally poor, and the 5-year overall survival rate of patients with atypical teratoid rhabdoid tumor is 29 ± 9%.

Natural History, Complications, and Prognosis

Natural History

If left untreated, patients with atypical teratoid rhabdoid tumor may progress to develop obstructive hydrocephalus, leptomeningeal dissemination, and ultimately death.^[1]

Complications

Common complications of atypical teratoid rhabdoid tumor include:^[1]^[2]

Prognosis

Prognosis is generally poor, and the 5-year overall survival rate of patients with atypical teratoid rhabdoid tumor is 29 ± 9%.^[3]
Patients usually succumb to atypical teratoid rhabdoid tumor between 6 months and 1 year from diagnosis.
Compared to medulloblastoma, atypical teratoid rhabdoid tumor has a significantly worse prognosis.
Older age at diagnosis is a favorable prognostic factor for atypical teratoid rhabdoid tumor.
Poor prognostic factors for atypical teratoid rhabdoid tumor include:^[4]

Germline mutation
Age < 2 years
Metastases at diagnosis
Subtotal resection
Large tumors
Recurrence

References

↑ ^1.0 ^1.1 Chan KH, Mohammed Haspani MS, Tan YC, Kassim F (2011). "A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl". Malays J Med Sci. 18 (3): 82–6. PMC 3216225. PMID 22135607.
↑ Udaka, Y. T.; Shayan, K.; Chuang, N. A.; Crawford, J. R. (2013). "Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child". Case Reports in Oncological Medicine. 2013: 1–4. doi:10.1155/2013/815923. ISSN 2090-6706.
↑ Ginn, Kevin F.; Gajjar, Amar (2012). "Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions". Frontiers in Oncology. 2. doi:10.3389/fonc.2012.00114. ISSN 2234-943X.
↑ Prognosis of atypical teratoid rhabdoid tumor. National Cancer Institute 2015. http://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq. Accessed on December 14, 2015

Template:WH Template:WS

[pmid22135607-1] 1.0 ^1.1 Chan KH, Mohammed Haspani MS, Tan YC, Kassim F (2011). "A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl". Malays J Med Sci. 18 (3): 82–6. PMC 3216225. PMID 22135607.

[UdakaShayan2013-2] Udaka, Y. T.; Shayan, K.; Chuang, N. A.; Crawford, J. R. (2013). "Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child". Case Reports in Oncological Medicine. 2013: 1–4. doi:10.1155/2013/815923. ISSN 2090-6706.

[GinnGajjar2012-3] Ginn, Kevin F.; Gajjar, Amar (2012). "Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions". Frontiers in Oncology. 2. doi:10.3389/fonc.2012.00114. ISSN 2234-943X.

[progatrt1-4] Prognosis of atypical teratoid rhabdoid tumor. National Cancer Institute 2015. http://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq. Accessed on December 14, 2015

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[2]

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[4]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Atypical teratoid rhabdoid tumor}}
-{{CMG}}
+{{CMG}}{{AE}}{{SR}}
 ==Overview==
-==Natural History, Complications and Prognosis==
+If left untreated, [[Patient|patients]] with atypical teratoid rhabdoid tumor may progress to develop [[obstructive hydrocephalus]], [[leptomeningeal]] dissemination, and ultimately death. Common [[Complication (medicine)|complications]] of atypical teratoid rhabdoid tumor include [[obstructive hydrocephalus]], [[leptomeningeal]] dissemination, and recurrence. [[Prognosis]] is generally poor, and the 5-year overall [[survival rate]] of [[Patient|patients]] with atypical teratoid rhabdoid tumor is 29 ± 9%.
+== Natural History, Complications, and Prognosis ==
+===Natural History===
+*If left untreated, [[Patient|patients]] with atypical teratoid rhabdoid tumor may progress to develop [[obstructive hydrocephalus]], [[leptomeningeal]] dissemination, and ultimately death.<ref name="pmid22135607">{{cite journal| author=Chan KH, Mohammed Haspani MS, Tan YC, Kassim F| title=A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl. | journal=Malays J Med Sci | year= 2011 | volume= 18 | issue= 3 | pages= 82-6 | pmid=22135607 | doi= | pmc=PMC3216225 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22135607  }} </ref>
+===Complications===
+*Common [[Complication (medicine)|complications]] of atypical teratoid rhabdoid tumor include:<ref name="pmid22135607">{{cite journal| author=Chan KH, Mohammed Haspani MS, Tan YC, Kassim F| title=A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl. | journal=Malays J Med Sci | year= 2011 | volume= 18 | issue= 3 | pages= 82-6 | pmid=22135607 | doi= | pmc=PMC3216225 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22135607  }} </ref><ref name="UdakaShayan2013">{{cite journal|last1=Udaka|first1=Y. T.|last2=Shayan|first2=K.|last3=Chuang|first3=N. A.|last4=Crawford|first4=J. R.|title=Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child|journal=Case Reports in Oncological Medicine|volume=2013|year=2013|pages=1–4|issn=2090-6706|doi=10.1155/2013/815923}}</ref>
+:*[[Obstructive hydrocephalus]]
+:*[[Leptomeningeal]] dissemination
+:*[[hemorrhage|Intratumoral hemorrhage]]
+:*Recurrence
 ===Prognosis===
-Most patients with AT/RT are less than three years old, the overall prognosis for AT/RT is very poor. Compared to medulloblastoma, AT/RT has a significantly worse prognosis.  AT/RT occurs in young children (often younger than three years) who are difficult to evaluate, it is resistant to many current therapies, and its recurrence is fast.
+*[[Prognosis]] is generally poor, and the 5-year overall [[survival rate]] of [[Patient|patients]] with atypical teratoid rhabdoid tumor is 29 ± 9%.<ref name="GinnGajjar2012">{{cite journal|last1=Ginn|first1=Kevin F.|last2=Gajjar|first2=Amar|title=Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions|journal=Frontiers in Oncology|volume=2|year=2012|issn=2234-943X|doi=10.3389/fonc.2012.00114}}</ref>
+*[[Patient|Patients]] usually succumb to atypical teratoid rhabdoid tumor between 6 months and 1 year from [[diagnosis]].
+*Compared to [[medulloblastoma]], atypical teratoid rhabdoid tumor has a significantly worse [[prognosis]].
+*Older age at [[diagnosis]] is a favorable [[Prognosis|prognostic]] factor for atypical teratoid rhabdoid tumor.
+*Poor [[Prognosis|prognostic]] factors for atypical teratoid rhabdoid tumor include:<ref name="progatrt1">Prognosis of atypical teratoid rhabdoid tumor. National Cancer Institute 2015. http://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq. Accessed on December 14, 2015</ref>
+:*[[Germline mutation]]
+:*Age < 2 years
+:*[[Metastasis|Metastases]] at [[diagnosis]]
+:*Subtotal [[resection]]
+:*Large [[Tumor|tumors]]
+:*Recurrence
 ==References==
 {{reflist|2}}
-{{WH}}
-{{WS}}
-[[Category:Oncology]]
 [[Category:Types of cancer]]
 [[Category:Rare cancers]]
@@ Line 20: / Line 42: @@
 [[Category:Pediatric cancers]]
 [[Category:Disease]]
+[[Category:Oncology]]
+{{WH}}
+{{WS}}