Atypical teratoid rhabdoid tumor natural history, complications and prognosis: Difference between revisions
No edit summary |
No edit summary |
||
(3 intermediate revisions by 2 users not shown) | |||
Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
If left untreated, patients with atypical teratoid rhabdoid tumor may progress to develop [[obstructive hydrocephalus]], leptomeningeal dissemination, and ultimately death. | If left untreated, [[Patient|patients]] with atypical teratoid rhabdoid tumor may progress to develop [[obstructive hydrocephalus]], [[leptomeningeal]] dissemination, and ultimately death. Common [[Complication (medicine)|complications]] of atypical teratoid rhabdoid tumor include [[obstructive hydrocephalus]], [[leptomeningeal]] dissemination, and recurrence. [[Prognosis]] is generally poor, and the 5-year overall [[survival rate]] of [[Patient|patients]] with atypical teratoid rhabdoid tumor is 29 ± 9%. | ||
==Natural History | == Natural History, Complications, and Prognosis == | ||
==Complications== | ===Natural History=== | ||
*Common complications of atypical teratoid rhabdoid tumor include:<ref name="pmid22135607">{{cite journal| author=Chan KH, Mohammed Haspani MS, Tan YC, Kassim F| title=A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl. | journal=Malays J Med Sci | year= 2011 | volume= 18 | issue= 3 | pages= 82-6 | pmid=22135607 | doi= | pmc=PMC3216225 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22135607 }} </ref> | *If left untreated, [[Patient|patients]] with atypical teratoid rhabdoid tumor may progress to develop [[obstructive hydrocephalus]], [[leptomeningeal]] dissemination, and ultimately death.<ref name="pmid22135607">{{cite journal| author=Chan KH, Mohammed Haspani MS, Tan YC, Kassim F| title=A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl. | journal=Malays J Med Sci | year= 2011 | volume= 18 | issue= 3 | pages= 82-6 | pmid=22135607 | doi= | pmc=PMC3216225 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22135607 }} </ref> | ||
===Complications=== | |||
*Common [[Complication (medicine)|complications]] of atypical teratoid rhabdoid tumor include:<ref name="pmid22135607">{{cite journal| author=Chan KH, Mohammed Haspani MS, Tan YC, Kassim F| title=A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl. | journal=Malays J Med Sci | year= 2011 | volume= 18 | issue= 3 | pages= 82-6 | pmid=22135607 | doi= | pmc=PMC3216225 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22135607 }} </ref><ref name="UdakaShayan2013">{{cite journal|last1=Udaka|first1=Y. T.|last2=Shayan|first2=K.|last3=Chuang|first3=N. A.|last4=Crawford|first4=J. R.|title=Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child|journal=Case Reports in Oncological Medicine|volume=2013|year=2013|pages=1–4|issn=2090-6706|doi=10.1155/2013/815923}}</ref> | |||
:*[[Obstructive hydrocephalus]] | :*[[Obstructive hydrocephalus]] | ||
:*Leptomeningeal dissemination | :*[[Leptomeningeal]] dissemination | ||
:*[[hemorrhage|Intratumoral hemorrhage]] | |||
:*Recurrence | :*Recurrence | ||
==Prognosis== | ===Prognosis=== | ||
*Prognosis is generally poor, and the 5-year overall survival rate of patients with atypical teratoid rhabdoid tumor is 29 ± 9%.<ref name="GinnGajjar2012">{{cite journal|last1=Ginn|first1=Kevin F.|last2=Gajjar|first2=Amar|title=Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions|journal=Frontiers in Oncology|volume=2|year=2012|issn=2234-943X|doi=10.3389/fonc.2012.00114}}</ref> | *[[Prognosis]] is generally poor, and the 5-year overall [[survival rate]] of [[Patient|patients]] with atypical teratoid rhabdoid tumor is 29 ± 9%.<ref name="GinnGajjar2012">{{cite journal|last1=Ginn|first1=Kevin F.|last2=Gajjar|first2=Amar|title=Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions|journal=Frontiers in Oncology|volume=2|year=2012|issn=2234-943X|doi=10.3389/fonc.2012.00114}}</ref> | ||
* | *[[Patient|Patients]] usually succumb to atypical teratoid rhabdoid tumor between 6 months and 1 year from [[diagnosis]]. | ||
*Compared to [[medulloblastoma]], atypical teratoid rhabdoid tumor has a significantly worse prognosis. | *Compared to [[medulloblastoma]], atypical teratoid rhabdoid tumor has a significantly worse [[prognosis]]. | ||
*Older age at diagnosis is a favorable prognostic factor for atypical teratoid rhabdoid tumor. | *Older age at [[diagnosis]] is a favorable [[Prognosis|prognostic]] factor for atypical teratoid rhabdoid tumor. | ||
*Poor prognostic factors for atypical teratoid rhabdoid tumor include:<ref name=progatrt1>Prognosis of atypical teratoid rhabdoid tumor. National Cancer Institute 2015. http://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq. Accessed on December 14, 2015</ref> | *Poor [[Prognosis|prognostic]] factors for atypical teratoid rhabdoid tumor include:<ref name="progatrt1">Prognosis of atypical teratoid rhabdoid tumor. National Cancer Institute 2015. http://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq. Accessed on December 14, 2015</ref> | ||
:*Germline mutation | :*[[Germline mutation]] | ||
:*Age < 2 years | :*Age < 2 years | ||
:*Metastases at diagnosis | :*[[Metastasis|Metastases]] at [[diagnosis]] | ||
:*Subtotal resection | :*Subtotal [[resection]] | ||
:*Large tumors | :*Large [[Tumor|tumors]] | ||
:*Recurrence | :*Recurrence | ||
Latest revision as of 18:39, 16 May 2019
Atypical teratoid rhabdoid tumor Microchapters |
Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Atypical teratoid rhabdoid tumor natural history, complications and prognosis On the Web |
American Roentgen Ray Society Images of Atypical teratoid rhabdoid tumor natural history, complications and prognosis |
FDA on Atypical teratoid rhabdoid tumor natural history, complications and prognosis |
CDC on Atypical teratoid rhabdoid tumor natural history, complications and prognosis |
Atypical teratoid rhabdoid tumor natural history, complications and prognosis in the news |
Blogs on Atypical teratoid rhabdoid tumor natural history, complications and prognosis |
Directions to Hospitals Treating Atypical teratoid rhabdoid tumor |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
If left untreated, patients with atypical teratoid rhabdoid tumor may progress to develop obstructive hydrocephalus, leptomeningeal dissemination, and ultimately death. Common complications of atypical teratoid rhabdoid tumor include obstructive hydrocephalus, leptomeningeal dissemination, and recurrence. Prognosis is generally poor, and the 5-year overall survival rate of patients with atypical teratoid rhabdoid tumor is 29 ± 9%.
Natural History, Complications, and Prognosis
Natural History
- If left untreated, patients with atypical teratoid rhabdoid tumor may progress to develop obstructive hydrocephalus, leptomeningeal dissemination, and ultimately death.[1]
Complications
- Common complications of atypical teratoid rhabdoid tumor include:[1][2]
- Obstructive hydrocephalus
- Leptomeningeal dissemination
- Intratumoral hemorrhage
- Recurrence
Prognosis
- Prognosis is generally poor, and the 5-year overall survival rate of patients with atypical teratoid rhabdoid tumor is 29 ± 9%.[3]
- Patients usually succumb to atypical teratoid rhabdoid tumor between 6 months and 1 year from diagnosis.
- Compared to medulloblastoma, atypical teratoid rhabdoid tumor has a significantly worse prognosis.
- Older age at diagnosis is a favorable prognostic factor for atypical teratoid rhabdoid tumor.
- Poor prognostic factors for atypical teratoid rhabdoid tumor include:[4]
- Germline mutation
- Age < 2 years
- Metastases at diagnosis
- Subtotal resection
- Large tumors
- Recurrence
References
- ↑ 1.0 1.1 Chan KH, Mohammed Haspani MS, Tan YC, Kassim F (2011). "A case report of atypical teratoid/rhabdoid tumour in a 9-year-old girl". Malays J Med Sci. 18 (3): 82–6. PMC 3216225. PMID 22135607.
- ↑ Udaka, Y. T.; Shayan, K.; Chuang, N. A.; Crawford, J. R. (2013). "Atypical Presentation of Atypical Teratoid Rhabdoid Tumor in a Child". Case Reports in Oncological Medicine. 2013: 1–4. doi:10.1155/2013/815923. ISSN 2090-6706.
- ↑ Ginn, Kevin F.; Gajjar, Amar (2012). "Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions". Frontiers in Oncology. 2. doi:10.3389/fonc.2012.00114. ISSN 2234-943X.
- ↑ Prognosis of atypical teratoid rhabdoid tumor. National Cancer Institute 2015. http://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq. Accessed on December 14, 2015