Ataxia differential diagnosis: Difference between revisions

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!EPIDEMIOLOGY
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!IMAGING FEATURES
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!ASSOCIATED FACTORS
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!SYMPTOMS
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|Acute cerebellitis
|Acute cerebellitis
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|More common in children and young adults
|More common in children and young adults
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* Normal or abnormal brain magnetic resonance imaging (MRI) at onset
*Normal or abnormal brain magnetic resonance imaging (MRI) at onset
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* Epstein-Barr virus, influenza A and B, mumps, varicella-zoster virus, coxsackie virus, rotavirus, echovirus, ''Mycoplasma pneumoniae'' and immunization
*Epstein-Barr virus, influenza A and B, mumps, varicella-zoster virus, coxsackie virus, rotavirus, echovirus, ''Mycoplasma pneumoniae'' and immunization
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* Mycoplasma pneumoniae, Listeria monocytogenes
*Mycoplasma pneumoniae, Listeria monocytogenes
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* Related to M. pneumonia, Epstein-Barr virus, herpes simplex virus, and toxoplasmosis
*Related to M. pneumonia, Epstein-Barr virus, herpes simplex virus, and toxoplasmosis
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|Chronic alcohol use/Alcoholic cerebellar degeneration
|Chronic alcohol use/Alcoholic cerebellar degeneration
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* Toxic effects on the central and peripheral nervous systems
*Toxic effects on the central and peripheral nervous systems


* Direct toxic alcoholic effect on the Purkinje cells
*Direct toxic alcoholic effect on the Purkinje cells
|Rapid progression (weeks or months)
|Rapid progression (weeks or months)
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* Vermis atrophy
*Vermis atrophy
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* Severe ataxia of gait and lower limbs with relatively mild involvement of the upper limbs.
*Severe ataxia of gait and lower limbs with relatively mild involvement of the upper limbs.


* Speech and ocular motility are usually preserved
*Speech and ocular motility are usually preserved
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|Antibiotic-induced acute ataxia
|Antibiotic-induced acute ataxia
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* Interaction of polymyxins with neurons has been associated with the occurrence of several neurotoxic events
*Interaction of polymyxins with neurons has been associated with the occurrence of several neurotoxic events
|Weeks after initiation
|Weeks after initiation
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* Brain MRI abnormalities
*Brain MRI abnormalities
* Characteristic reversible MRI signal abnormalities in the cerebellar dentate nuclei, dorsal brainstem, or splenium of the corpus callosum
*Characteristic reversible MRI signal abnormalities in the cerebellar dentate nuclei, dorsal brainstem, or splenium of the corpus callosum


* Non-specific EEG abnormalities
*Non-specific EEG abnormalities
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* Ataxia may also occur in isolation or combined with dizziness, generalized muscle weakness, partial deafness, visual disturbances, vertigo, confusion, hallucinations, seizures, and neuromuscular blockade
*Ataxia may also occur in isolation or combined with dizziness, generalized muscle weakness, partial deafness, visual disturbances, vertigo, confusion, hallucinations, seizures, and neuromuscular blockade
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Revision as of 15:18, 24 August 2020

TYPE CAUSE PROGRESSION EPIDEMIOLOGY IMAGING FEATURES ASSOCIATED FACTORS SYMPTOMS
Acute cerebellitis More common in children and young adults
  • Normal or abnormal brain magnetic resonance imaging (MRI) at onset
  • Epstein-Barr virus, influenza A and B, mumps, varicella-zoster virus, coxsackie virus, rotavirus, echovirus, Mycoplasma pneumoniae and immunization
Bacterial infection
  • Mycoplasma pneumoniae, Listeria monocytogenes
Acquired immunodeficiency syndromes
  • Related to M. pneumonia, Epstein-Barr virus, herpes simplex virus, and toxoplasmosis
Chronic alcohol use/Alcoholic cerebellar degeneration
  • Toxic effects on the central and peripheral nervous systems
  • Direct toxic alcoholic effect on the Purkinje cells
Rapid progression (weeks or months)
  • Vermis atrophy
  • Severe ataxia of gait and lower limbs with relatively mild involvement of the upper limbs.
  • Speech and ocular motility are usually preserved
Antibiotic-induced acute ataxia
  • Interaction of polymyxins with neurons has been associated with the occurrence of several neurotoxic events
Weeks after initiation
  • Brain MRI abnormalities
  • Characteristic reversible MRI signal abnormalities in the cerebellar dentate nuclei, dorsal brainstem, or splenium of the corpus callosum
  • Non-specific EEG abnormalities
  • Ataxia may also occur in isolation or combined with dizziness, generalized muscle weakness, partial deafness, visual disturbances, vertigo, confusion, hallucinations, seizures, and neuromuscular blockade
Para-neoplastic syndrome
Vitamin deficiency
Chronic infections
Neurodegenerative diseases
Brain tumors
Stroke
Vestibular neuritis
Sjögren syndrome

References


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